Antiplasmodial Activity of Labdanes from Aframomum latifolium and Aframomum sceptrum

Abstract

Bioguided fractionation of extracts of Aframomum latifolium and A. sceptrum (Zingiberaceae) resulted in isolation of (+)-( S)-nerolidol and seven labdanes, coronarin B, galanal A and B, galanolactone, ( E)-8beta,17-epoxylabd-12-ene-15,16-dial, (+)-( E)-labda-8(17), 12-diene-15,16-dial and its diethyl acetal, the latter being presumably an isolation artefact. The labdanes show a modest in vitro activity against a chloroquine-sensitive Plasmodium falciparum strain.

Terpenes Arrest Parasite Development and Inhibit Biosynthesis of Isoprenoids inPlasmodium falciparum

“…1, lanes 5 and 6). Antimalarial activity by essential oils that contain nerolidol has been described previously by us and others (7,12). The IC 50 of nerolidol for isolate NF54, clone 3D7, of P. falciparum was quite different from that described by us for isolate S20 (7); however, both isolates presented identical inhibition of dolichol and ubiquinone biosynthesis without inhibiting of farnesol and geraniol.…”

Antiparasitic activities of medicinal plants used in Ivory Coast

“…The first one, with an IC 50 corresponding to 1.5 g/ml, has a comparable activity with that of Anogeissus leiocarpus and Terminalia glaucescens. For Aframomum sceptrum, labdanes diterpenoids have been shown to have in vitro, antimalarial activity (Duker-Eshun et al, 2002).…”

Medicinal plants from the Yanesha (Peru): Evaluation of the leishmanicidal and antimalarial activity of selected extracts

“…Renealmia alpinia has been reported as febrifuge in Suriname and cytotoxic labadanes terpenes were isolated from its leaves (Zhou et al, 1997;Yang et al, 1999). Labdane diterpenes isolated from African Zingiberaceae have been showed to inhibit plasmodial growth at M concentrations (Duker-Eshun et al, 2002;Kenmogne et al, 2006). But the genus Renealmia is known also for arylheptanoids contents (Sekiguchi et al, 2002).…”