Antiplatelet Effect of Gingerol Isolated from Zingiber officinale

Guh, Jih‐Hwa; Ko, Feng‐Nien; Jong, Ting‐Ting; Chen, Teng

doi:10.1111/j.2042-7158.1995.tb05804.x

Cited by 94 publications

(51 citation statements)

References 16 publications

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“…Since it has been established that stimulation of prostanoid receptors caused contraction in the guinea pig ileum (34), prostaglandin-like compounds may be involved in [6]-gingerol-induced contraction. However, [6]-gingerol is reported to be an inhibitor of prostaglandin synthetase and 5-lipoxygenase in vitro (35,36). As treatment with indomethacin did not modify the contraction induced by [6]-gingerol, the effects of [6]-gingerol did not appear to be due to prostaglandin(s) formation.…”

Section: Involvement Of Nk 1 Receptors and Prostaglandins Formation Omentioning

confidence: 95%

Modifications of Capsaicin-Sensitive Neurons in Isolated Guinea Pig Ileum by [6]-Gingerol and Lafutidine

et al. 2003

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Abstract. A segment of guinea pig ileum was used to confirm the hypothesis that [6]-gingerol and lafutidine interact with capsaicin-sensitive neurons. Addition of 30 and 100 m M [6]-gingerol (a pungent constituent of ginger) induced contraction of the ileum immediately. Like capsaicin, [6]-gingerol-induced contraction was inhibited by antagonists of the vanilloid receptor (capsazepine and ruthenium red), tetrodotoxin, and atropine. Treatment with [6]-gingerol up to 0.3 m M, which alone had no effect, enhanced 3 m M capsaicin-induced contraction, but greater than 3 mM [6]-gingerol significantly inhibited capsaicin-induced contraction. Treatment with lafutidine (a new type of antagonist of the histamine H 2 receptor), which was suggested to interact with capsaicin-sensitive neurons in vivo, also showed both stimulatory and inhibitory effects on capsaicin-induced contraction depending on the concentrations. Lafutidine alone had no effect. The enhanced contraction induced by capsaicin in the [6]-gingerol-or lafutidine-treated ileum was also inhibited by antagonists of the vanilloid receptor, tetrodotoxin, and atropine. Capsaicin and [6]-gingerol, but not lafutidine, at 30 m M stimulated [ 3 H]choline release from the prelabeled slices of the ileum. These findings suggest that [6]-gingerol and lafutidine act on capsaicin-sensitive cholinergic neurons and modulate the contraction in isolated guinea pig ileum.

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Section: Involvement Of Nk 1 Receptors and Prostaglandins Formation Omentioning

confidence: 95%

Modifications of Capsaicin-Sensitive Neurons in Isolated Guinea Pig Ileum by [6]-Gingerol and Lafutidine

et al. 2003

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“…[16][17][18][19] The anti-inflammatory effect of zingiber officinale has been scientific investigations reported concentration-dependent inhibition of arachidonic acid-induced platelet aggregation and formation of thromboxane B. Gingerol, shogaol, and other structurally-related substances in ginger inhibit prostaglandin and leukotriene biosynthesis through suppression of 5-lipoxygenase or prostaglandin synthetase and also inhibit synthesis of IL-1, TNF-α and IL-8 as proinflammatory cytokines. 20,21 Antioxidant are rich in Zingiber officinale preparations and effective in reducing the extent of diabetes mellitus, pregnancy-induced maladies, arthritis, etc. This drug considered a safe herbal medicine with few adverse effects.…”

Section: Discussionmentioning

confidence: 99%

Analgesic activity of Cissus quadrangularis linn with Zingiber officinale rosc in male wistar rats

Santosh¹,

Cheekavolu²,

Leela

et al. 2017

Int J Basic Clin Pharmacol

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Background: The global scenario, human beings are using various forms of treatment for relief of pain; among them, medicinal plant products have gained popularity because of its wide range of use and less side effects.Methods: Adult Albino rats of either sex were selected and divided into 5 groups. The Eddy’s hot plate was used and maintained temperature (55±0.5ºC), the animals were placed on the hot plate and the time taken for paw licking or jumping was recorded and considered as nociceptive response. The reaction time was observed on 0, 30, 60, and 90 minute.Results: The hot plate reaction time in sec was collected in the intervals of 0, 30, 60 and 90 minutes in all groups. Reaction times as follows: group III (Cissus quadrangularis Linn.) were 2.18±0.04, 3.13±0.05**, 5.83±0.05**, 5.39±0.04**; Group IV (Zingiber officinale Rosc.) were 2.12±0.03, 4.13±0.04**, 7.43±0.07**, 7.16±0.06**; Group V Cissus quadrangularis Linn+ Zingiber officinale Rosc.) were 2.21±0.75, 4.67±0.98**, 8.15±0.89**, 9.02±0.75**; Group II (Dexamethasone) were 2.14±0.05, 5.53±0.05**, 8.14±0.06**, 10.08±0.10** respectively, Results are presented as mean±SEM, (n=6), *p<0.01, **p<0.05 dunnet test used as compared to control.Conclusions: Present study reveals that, the combination treatment of Zingiber officinale Rosc. + Cissus quadrangularis Linn. has been shown significant analgesic effect. High analgesic effect was observed with combination therapy; the effect was shown same as standard drug dexamethasone.

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“…The pungent compounds of Z. officinale include gingerols, shogaols, paradols and zingerone 9, . Rhizomes of Z. officinale and its constituents have been proven for their antioxidant 10 and antiplatelet efficacies 11 .…”

Section: Issn: 0975-8232mentioning

confidence: 99%

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2012

IJPSR

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An in vitro study was conducted for screening antibacterial activities of seeds of Trigonella foenum-graecum (fenugreek) and rhizomes of Zingiber officinale (ginger), in their different forms viz. aqueous extracts, essential oils and powders against some common food borne pathogens. Bacterial strains involved in the study were Bacillus cereus (MTCC 430) , Enterococcus feacalis (MTCC 439), Escherichia coli (MTCC 1687), Psuedomonas aeruginosa (MTCC 424) and Staphylococcus aureus (MTCC 5021).Results revealed that powdered forms of T. foenum-graecum and Z. officinale remained ineffective in arresting the growth of all the bacterial strains under investigation. During preliminary screening, aqueous extracts and essential oils of test spices did not exhibit any growth inhibitory zone towards any test bacteria. In broth dilution technique, essential oil of Z. officinale arrested all the bacterial strains under observation while essential oil of T. foenum-graecum and aqueous extracts of T. foenum-graecum and Z. officinale remained ineffective.

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Antiplatelet Effect of Gingerol Isolated from Zingiber officinale

Cited by 94 publications

References 16 publications

Modifications of Capsaicin-Sensitive Neurons in Isolated Guinea Pig Ileum by [6]-Gingerol and Lafutidine

Modifications of Capsaicin-Sensitive Neurons in Isolated Guinea Pig Ileum by [6]-Gingerol and Lafutidine

Analgesic activity of Cissus quadrangularis linn with Zingiber officinale rosc in male wistar rats

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