Antiplatelet prenylflavonoids from Artocarpus communis

Weng, Jing‐Ru; Chan, Sheng-Ching; Lu, Yi‐Huang; Lin, Hsien-Cheng; Ko, Horng‐Huey; Lin, Chun‐Nan

doi:10.1016/j.phytochem.2006.01.030

Cited by 55 publications

(53 citation statements)

References 11 publications

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“…A large number of phenolic compounds including flavonoids, stilbenoids, and 2-arylbenzofurons have been isolated from Artocarpus plants and possess a wide range of biological properties such as anti-inflammatory (Hsu et al, 2012;Lin et al, 2011), antiplatelet (Jagtap & Bapat, 2010;Weng et al, 2006), antimycobacterial (Loizzo et al, 2010;Siritapetawee et al, 2012), and antiprotozoal activities (Bourjot et al, 2010). Among these activities, the antioxidant actions of these polyphenols derived from Artocarpus species have been frequently reported in vivo and in vitro (Omar et al, 2011;Sidahmed et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effects of phenolic compounds fromArtocarpus styracifoliuson respiratory burst of rat neutrophils

Ren

Xiang²,

Hu³

et al. 2014

Pharmaceutical Biology

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Materials and methods:The anti-respiratory burst activities of eight phenolics (20 mM) were assessed by determining luminol-dependent chemiluminiscence in rat PMNs. Cytotoxicity of active compounds (1-1000 mM) was assayed by Trypan blue dye exclusion method. Cell-free models were employed to evaluate scavenging capacity of active compounds (20 mM) against reactive oxygen species.Results: The PMA-induced respiratory burst was significantly inhibited (p50.05) by six isoprenylated phenolics (AS1-6) at the concentration of 20 mM (below the toxic concentration) with the inhibition rate ranging from 25.0 to 99.6%. The inhibitory potency estimated by IC 50 was in the order of AS1 (3.1 mM) 4AS6 (5.9 mM) 4AS2 (9.1 mM) 4AS3 (10.0 mM) 4AS5 (29.7 mM) 4AS4 (57.7 mM). AS1-4, four isoprenylated flavones, potently quenched superoxide anion, hydroxyl radical, and hydrogen peroxide at the concentration of 20 mM with their scavenging rates in the range of 30.1-78.1%, 35.4-69.7%, and 65.5-86.3%, respectively. In contrast, AS5-6, two isoprenylated 2-arylbenzofurans, showed less effect than that exhibited by AS1-4. Conclusion and discussion: The isoprenylated phenolics from A. styracifolius can potently inhibit PMA-induced respiratory burst in rat neutrophils without showing cytotoxicity. The inhibitory effects of these isoprenylated phenolics on the respiratory burst might depend on their different types of structure.

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Section: Discussionmentioning

confidence: 99%

Inhibitory effects of phenolic compounds fromArtocarpus styracifoliuson respiratory burst of rat neutrophils

Ren

Xiang²,

Hu³

et al. 2014

Pharmaceutical Biology

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“…In Cameroon, the fruits of A. communis are used as food; other parts of the plants are traditionally used to treat headache, infectious and associated diseases such as toothache, eye problems, ear infections, herpes, enlarged spleen, sprains, contusions, swelling [3-5]. Some scientific evidences of the bioactivity of A. communis were reported on the extract or isolated compounds [6-9]. However, few reports are related to the antimicrobial activity of this taxon.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activities of the methanol extract and compounds from Artocarpus communis (Moraceae)

Kuete

Ango

Fotso

et al. 2011

BMC Complement Altern Med

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BackgroundArtocarpus communis is used traditionally in Cameroon to treat several ailments, including infectious and associated diseases. This work was therefore designed to investigate the antimicrobial activities of the methanol extract (ACB) and compounds isolated from the bark of this plant, namely peruvianursenyl acetate C (1), α-amyrenol or viminalol (2), artonin E (4) and 2-[(3,5-dihydroxy)-(Z)-4-(3-methylbut-1-enyl)phenyl]benzofuran-6-ol (5).MethodsThe liquid microdilution assay was used in the determination of the minimal inhibitory concentration (MIC) and the minimal microbicidal concentration (MMC), against seven bacterial and one fungal species.ResultsThe MIC results indicated that ACB as well as compounds 4 and 5 were able to prevent the growth of all tested microbial species. All other compounds showed selective activities. The lowest MIC value of 64 μg/ml for the crude extract was recorded on Staphylococcus aureus ATCC 25922 and Escherichia coli ATCC 8739. The corresponding value of 32 μg/ml was recorded with compounds 4 and 5 on Pseudomonas aeruginosa PA01 and compound 5 on E. coli ATCC 8739, their inhibition effect on P. aeruginosa PA01 being more than that of chloramphenicol used as reference antibiotic.ConclusionThe overall results of this study provided supportive data for the use of A. communis as well as some of its constituents for the treatment of infections associated with the studied microorganisms.

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“…The UV spectrum in MeOH displayed absorption bands at λ max 218, 261 and 363 nm, suggesting a flavonoid skeleton. 16,17 The IR spectrum showed absorption bands of hydroxy (3339 cm ). The molecular formula, C 17 H 12 O 8 , implying twelve double bond equivalents, was deduced from NMR data and by HR-ESIMS (see exp.…”

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confidence: 99%

Ingacamerounol, A New Flavonol and Other Chemical Constituents from Leaves and Stem Bark of Inga edulis Mart.

Tchuenmogne¹,

Donfack²,

Kongue³

et al. 2013

Bulletin of the Korean Chemical Society

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Antiplatelet prenylflavonoids from Artocarpus communis

Cited by 55 publications

References 11 publications

Inhibitory effects of phenolic compounds fromArtocarpus styracifoliuson respiratory burst of rat neutrophils

Inhibitory effects of phenolic compounds fromArtocarpus styracifoliuson respiratory burst of rat neutrophils

Antimicrobial activities of the methanol extract and compounds from Artocarpus communis (Moraceae)

Ingacamerounol, A New Flavonol and Other Chemical Constituents from Leaves and Stem Bark of Inga edulis Mart.

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