Antiproliferative activity of semisynthetic xylopic acid derivatives

Soh, Desiré; Ernestine, Nkwengoua; Satchet, Emmanuella Marthe Tchana; Defokou, Ulrich Dzo; Schneider, Bernd; Vidari, Giovanni; Nyasse, Barthélémy

doi:10.1080/14786419.2021.1876045

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…A perusal of extant scientific literature on XA (15β-acetoxyent-kaur-16-en-19-oic acid) reveals reports on the pharmacokinetics and in vitro microsomal liver enzyme metabolism (Alolga, et al, 2023a), forced degradation studies (Alolga, et al, 2023b), quantitative analyses (Adosraku & Oppong Kyekyeku, 2011;Kyekyeku et al, 2020), semi-synthesis (Soh et al, 2022) and evaluations of diverse biological activities.…”

Section: Xylopic Acid (Xa)mentioning

confidence: 99%

“…Other bioactivities reported for XA include antimalarial (Boampong et al, 2013;Ameyaw et al, 2018;Osei et al, 2021), antimicrobial (Boakye-Yiadom et al, 1977), antinociceptive (Woode et al, 2015), analgesic (Woode et al, 2013;Ameyaw et al, 2014;Woode et al, 2016), antiproliferative (Soh et al, 2022), antidepressant-like (Biney et al, 2021), and cardiovascular and diuretic (Somova et al, 2001) effects.…”

Section: Xylopic Acid (Xa)mentioning

confidence: 99%

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Ent-kaurane diterpenoids from the Annonaceae family: a review of research progress and call for further research

Ibrahim,

Khongorzul,

Muyaba

et al. 2023

Front. Pharmacol.

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The Annonaceae is one of the plant families with members that are credited with numerous pharmacological functions. Among the group of compounds responsible for these bioactivities are the ent-kaurane diterpenoids. The ent-kauranes are a group of 20-Carbon, tetracyclic diterpenoids that are widely distributed in other plant families including the Annonaceae family. This mini-review focuses mainly on the ent-kaurane diterpenoids isolated from the Annonaceae family, delineates the various biological activities of these compounds, and highlights the research gaps that exist for further scientific scrutiny.

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