Antiproliferative effect of a traditional remedy, Himatanthus articulatus bark, on human cancer cell lines

Rebouças, Sebastião de O.; Grivicich, Ivana; Santos, Marcelo Soares Teles; Rodriguez, Priscila; Gomes, Maitê Dória; Oliveira, Simone Quintana de; Silva, Juliana da; Ferraz, Alexandre de Barros Falcão

doi:10.1016/j.jep.2011.06.006

Cited by 15 publications

(5 citation statements)

References 27 publications

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“…Some studies revealed that plumieride exhibits antimicrobial[ 61 ] and antioxidant effects,[ 62 ] arrests spermatogenesis in male rats without noticeable side effects, and presents cytotoxicity. [ 3 ]…”

Section: Resultsmentioning

confidence: 99%

“…[ 4 ] Their barks showed cytotoxic and trypanocidal and leishmanicidal effects, also reported in folk medicine. [ 2 3 5 6 ] Leishmaniasis is a parasitic disease responsible for considerable mortality and morbidity, affecting many people every year. [ 4 ] Leishmania donovani is the causative agent of visceral leishmaniasis, which is fatal in the absence of treatment.…”

Section: Resultsmentioning

confidence: 99%

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Himatanthus Willd. ex Schult. (Apocynaceae): Review

Soares¹,

Cavalcante²,

Romero³

et al. 2016

Phcog Rev

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The genus Himatanthus Wild. ex Schult. (Apocynaceae) includes about 13 species and five subspecies widely distributed in South America, especially Brazil. The phytochemical reports on this genus have revealed mainly triterpenes and iridoids. The plants are traditionally used as anthelmintic, antitumor, and antiinflammatory agents. The most used parts of the plant are its bark, leaves, and latex. This review emphasizes the phytochemical constituents and medicinal properties, which may help in future research. The research was conducted with data obtained from books about medicinal plants, theses, dissertations, and articles in refereed journals.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Himatanthus Willd. ex Schult. (Apocynaceae): Review

Soares¹,

Cavalcante²,

Romero³

et al. 2016

Phcog Rev

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show abstract

“…Himatanthus articulatus belongs to the Apocynaceae family, which is known to produce alkaloids [ 38 ]. However, previous studies have not yet described the isolation of alkaloids in this species [ 20 , 39 ]. Possibly, this class of natural products is a minor constituent in H. articulatus , if present at all.…”

Section: Resultsmentioning

confidence: 99%

Anti-malarial activity and toxicity assessment of Himatanthus articulatus, a plant used to treat malaria in the Brazilian Amazon

Vale

Vilhena

Trindade

et al. 2015

Malar J

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BackgroundPlasmodium falciparum has become resistant to some of the available drugs. Several plant species are used for the treatment of malaria, such as Himatanthus articulatus in parts of Brazil. The present paper reports the phyto-chemistry, the anti-plasmodial and anti-malarial activity, as well as the toxicity of H. articulatus.MethodsEthanol and dichloromethane extracts were obtained from the powder of stem barks of H. articulatus and later fractionated and analysed. The anti-plasmodial activity was assessed against a chloroquine resistant strain P. falciparum (W2) in vitro, whilst in vivo anti-malarial activity against Plasmodium berghei (ANKA strain) was tested in mice, evaluating the role of oxidative stress (total antioxidant capacity - TEAC; lipid peroxidation – TBARS, and nitrites and nitrates - NN). In addition, cytotoxicity was evaluated using the HepG2 A16 cell-line. The acute oral and sub-chronic toxicity of the ethanol extract were evaluated in both male and female mice.ResultsPlumieride was isolated from the ethyl acetate fraction of ethanol extract, Only the dichloromethane extract was active against clone W2. Nevertheless, both extracts reduced parasitaemia in P. berghei-infected mice. Besides, a significant reduction in pulmonary and cerebral levels of NN (nitrites and nitrates) was found, as well as in pulmonary TBARS, indicating a reduced oxidative damage to these organs. The ethanol extract showed low cytotoxicity to HepG2 A16 cells in the concentrations used. No significant changes were observed in the in vivo toxicity studies.ConclusionsThe ethanol extract of H. articulatus proved to be promising as anti-malarial medicine and showed low toxicity.

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“…This species has already been subjected to phytochemical studies (Table 2). Steroids from H. articulatus were identified, and triterpenic esters such as plumieride, isoplumieride, and plumierin were isolated (Silva, et al, 1998;Rebouças, et al, 2011;Vale, et al, 2015).…”

Section: Apocynaceae and Its Reported Use In Treating Cancer And Tumorsmentioning

confidence: 99%

“…The aqueous extract of the bark of H. articulatus was evaluated for anticancer activity in different cell lines and showed activity against the lung epithelial cancer cells (NCI-H460; Table 3; Rebouças, et al, 2011). An ethanolic extract from the bark of H. articulatus was subjected to acute and subchronical toxicity evaluation and did not show significant clinical changes.…”

Section: Apocynaceae and Its Reported Use In Treating Cancer And Tumorsmentioning

confidence: 99%

Antitumor activity of Apocynaceae species used in Amazon traditional medicine

Bastos

Sarmento

Bahia

et al. 2020

RSD

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This study reviews the use of Apocynaceae species for cancer and tumor treatment in the Amazon. Databases and books were searched for ethnobotanical and phytochemical evaluations of the cytotoxic and anticancer activities of Apocynaceae species. The literature reports the use of several Amazonian species, such as Asclepias curassavica, Himatanthus articulates, and Macoubea sprucei, in treating tumors and cancers. Phytochemical studies on A. curassavica and H. articulatus have shown their chemical compositions to be variable, possessing cardenolides, iridoids, flavonoids, steroids, and terpenes. Most of the species have not been subjected to in vitro experiments for anticancer activity, and the evaluated species showed moderate-to-weak responses or were inactive. Other studies have shown that iridoids, flavonoids, and steroids are promising as antitumor treatments. The following action mechanisms have been attributed to iridoids: topoisomerase I-DNA complex stabilization, cellular cytoskeleton alteration, and induction of apoptosis. The activities of flavonoids have been reported to include apoptosis induction in liver tumor cells. Some authors suggest that flavonoids reduce oxidative stress cellular response which reduces mitochondrial dysfunction and cell death. In summary, Apocynaceae species appear to be promising as a source for antitumor agents; however, further studies are required to confirm their antitumor activities and to better elucidate the underlying mechanisms involved.

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Antiproliferative effect of a traditional remedy, Himatanthus articulatus bark, on human cancer cell lines

Cited by 15 publications

References 27 publications

Himatanthus Willd. ex Schult. (Apocynaceae): Review

Himatanthus Willd. ex Schult. (Apocynaceae): Review

Anti-malarial activity and toxicity assessment of Himatanthus articulatus, a plant used to treat malaria in the Brazilian Amazon

Antitumor activity of Apocynaceae species used in Amazon traditional medicine

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