Antipyretic Activity of Aqueous and Ethanolic Extract of Cassia Alata Linn Leaf

Sy, Timothy; Wazis, CH; Zakama, SG; Dawurung, JS; Albert, T

doi:10.7897/2277-4343.03625

Cited by 6 publications

(8 citation statements)

References 5 publications

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“…The crude extracts of C. alata also demonstrated a concentration-dependant antimicrobial activity. These findings were in line with previously reported findings [85][86][87]. When the extract concentration was gradually reduced to 1 µg µL −1 , only three extracts remained susceptible to S. aureus (p < 0.06, p = 0.01).…”

Section: Discussionsupporting

confidence: 93%

In vitro antimicrobial efficacy of Cassia alata (Linn.) leaves, stem, and root extracts against cellulitis causative agent Staphylococcus aureus

Toh

Lihan

Bunya

et al. 2023

BMC Complement Med Ther

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Background Cellulitis is a common skin disease encountered in medical emergencies in hospitals. It can be treated using a combination of antibiotics therapy; however, the causative agent Staphylococcus aureus has been reported to develop resistance towards the currently used antibiotics. Therefore, the search for more alternative herbal origin antimicrobial agents is critical. Aim: In this study, maceration and Soxhlet extraction of the whole plant of Cassia alata Linn. (leaves, roots, and stem) were performed using four solvents with different polarities, namely n-hexane, ethyl acetate, ethanol and distilled water. The crude extracts were screened using agar well diffusion, colorimetric broth microdilution, grid culture and bacterial growth curve analysis against Staphylococcus aureus. The phytochemicals in the crude extracts were identified using Gas Chromatography-Mass Spectrometry (GC–MS). Results Agar-well diffusion analysis revealed that extraction using ethyl acetate showed the largest inhibition zone with an average diameter of 15.30 mm (root Soxhlet extract) followed by 14.70 mm (leaf Soxhlet extract) and 13.70 mm (root maceration extract). The lowest minimum inhibitory and minimum bactericidal concentration in root Soxhlet extract using ethyl acetate was 0.313 and 0.625 µg µL−1, respectively. Our study proved that crude extract of the plant suppressed the growth of S. aureus as evidenced from a significant regression extension (p < 0.06, p = 0.00003) of lag phase for 6 h after the treatment with increased concentration. Based on the GC–MS analysis, 88 phytochemicals consist of fatty acids, esters, alkanes, phenols, fatty alcohols, sesquiterpenoids and macrocycle that possibly contributed to the antimicrobial properties were identified, 32 of which were previously characterized for their antimicrobial, antioxidant, and anti-inflammatory activities. Conclusion Ethyl acetate crude extract was better than the other investigated solvents. The root and stem of C. alata showed significant antimicrobial efficacy against S. aureus in this study. The remaining 56 out of 88 phytochemicals of the plant should be intensively studied for more medicinal uses.

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Section: Discussionsupporting

confidence: 93%

In vitro antimicrobial efficacy of Cassia alata (Linn.) leaves, stem, and root extracts against cellulitis causative agent Staphylococcus aureus

Toh

Lihan

Bunya

et al. 2023

BMC Complement Med Ther

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“…Cassia alata commonly known as 'Ketepeng' in Indonesia, is traditionally used to cure skin lesion like tinea and ringworm, constipation, and stomatitis 16 . Ethanolic extract of Cassia alata leaf has an antipyretic effect which is higher than paracetamol 20 . Centella asiatica, known as 'Pegagan', is a herb that has been used for healing wound and leprosy in the folk medicine in Asia.…”

Section: Discussionmentioning

confidence: 93%

In Vivo Anti-Hypercholesterolemia Effect of Indonesian Jamu Formula

Husnawati¹,

Batubara²,

Ardiyanto³

et al. 2017

Int. J. Res. Ayurveda Pharm.

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Indonesia has many Jamu formulas to threat some diseases including for hypercholesterolemia. Aim of this research were to standardize and analyze the effectiveness of Jamu Formula as anti-hypercholesterolemia and see its toxicity to liver function. Jamu Formula in this research consisted of Syzygium polyanthum, Casia alata, and Centella asiatica leaves which were extracted by ethanol 30%, and Curcuma xanthorrhiza rhizome which were extracted by ethanol 70%. This Jamu fomula can inhibit HMGCoA reductase activity in previous study. This study was conducted in animals laboratory of Tropical Biopharmaca Research Center, Bogor, Indonesia. In vivo analysis using Sprague dawley rats fed a high-fat diet for 4 weeks, then treated with Jamu Formula for 2 weeks. Blood collection performed before and after treatment. The results showed that Jamu Formula have a good quality for plant raw material and safe to be used. It had LD50 higher than 5000 mg/kg BW. The Jamu formula dose 360 mg/kg BW can decreased cholesterol level and body weight of rats about1,5 and 2,5 times relative to negative control group. Total cholesterol and LDL level of Jamu formula dose 360 mg/kg BW can decrease to 92.4 ± 5.0 and 25.8 ± 8.6 mg/dL which was not significantly different with normal and simvastatin group. In conclusion, Jamu formula dose 360 mg/kg BW have anti-hypercholesterolemia effect as good as simvastatin group.

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“…17 Selain sebagai bahan antibakteri, ekstrak etanol dan akuades daun ketepeng cina juga dimanfaatkan sebagai zat antipiretik. 18 Kandungan flavonoid pada tanaman herbal memiliki efek antiinflamasi, antialergi, antimikroba, antioksidan, dan efektik sebagai antifungsi untuk beberapa golongan jamur. 14,19 Berdasarkan hasil penelitin yang dilakukan oleh Putri dkk.…”

Section: Pendahuluanunclassified

“…Selain itu, kandungan kimia pada daunnya adalah alkaloid, saponin, flavonoid, tannin, dan antrakuinon. 34,35 Candida albicans telah dikenal dan dipelajari sejak abad ke- 18…”

Section: Pendahuluanunclassified

Kadar Hambat Minimum (KHM) dan Kadar Bunuh Minimum (KBM) Ekstrak Etanol Daun Ketepeng Cina (Cassia alata L.) Terhadap Pertumbuhan Candida albicans

Gharnita¹,

Lelyana²,

Sugiaman³

2019

sod

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Candida albicans merupakan jamur dimorfik oportunistik penyebab utama oral candidiasis. Salah satu obat oral candidiasis yang suing digunakan adalah nistatin namun memiliki banyak efek samping maka dibutuhkan pengobatan alternatif dengan memanfaatkan tanaman herbal seperti daun ketepeng cina (Cassia alata L.). Penelitian ini bertujuan untuk mengetahui kadar hambat minimum (KHM) dan kadar bunuh minimum (KBM) ekstrak etanol daun ketepeng cina (Cassia alata L.) terhadap pertumbuhan Candida albicans dengan menghitung jumlah yeast. Penelitian ini bersifat eksperimental laboratorium dengan membandingkankelompok uji yang mengandung ekstrak daun ketepeng cina (Cassia alata L.) dengan konsentrasi 200 mg/mL; 100 mg/mL; 50 mg/mL; 25 mg/mL; 12,5 mg/mL; 6,25 mg/mL dan 3,125 mg/mL yang ditanam dalam media PDA. Kontrol positif berupa nistanin, dan media PDB sedangkan kontrol negatif berupa media PDB, dan DMSO 10% terhadap Candida albicans yang sebelumnya telah diinkubasi pada suhu 37oC selama 24 jam dan dilakukan pengulangan sebanyak empat kali. Berdasarkan basil penelitian diketahui bahwa ekstrak etanol daun ketepeng cina (Cassia alata L.) mampu menghambat pertumbuhan Candida albicans pada konsentrasi 200 mg/mL secara sig (p<0,05) namun tidak dapat membunuh Candida albicans. Simpulan dari penelitian ini menunjukkan bahwa ekstrak etanol daun ketepeng cina (Cassia alata L.) dapat menghambat pertumbuhan Candida albicans.

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Antipyretic Activity of Aqueous and Ethanolic Extract of Cassia Alata Linn Leaf

Cited by 6 publications

References 5 publications

In vitro antimicrobial efficacy of Cassia alata (Linn.) leaves, stem, and root extracts against cellulitis causative agent Staphylococcus aureus

In vitro antimicrobial efficacy of Cassia alata (Linn.) leaves, stem, and root extracts against cellulitis causative agent Staphylococcus aureus

In Vivo Anti-Hypercholesterolemia Effect of Indonesian Jamu Formula

Kadar Hambat Minimum (KHM) dan Kadar Bunuh Minimum (KBM) Ekstrak Etanol Daun Ketepeng Cina (Cassia alata L.) Terhadap Pertumbuhan Candida albicans

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