Antiseptics and Disinfectants: Activity, Action, and Resistance

McDonnell, Gerald; Russell, A. D.

doi:10.1128/cmr.12.1.147

Cited by 3,916 publications

(3,071 citation statements)

References 461 publications

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“…Previous research has also demonstrated that photoirradiated TiO 2 catalyzed site-specific DNA damage by generating H 2 O 2 (Hirakawa et al 2004). These findings suggested that TiO 2 might exert similar antimicrobial effects to those of the disinfectant H 2 O 2 (McDonnell and Russell 1999). The oxidation of bacterial cell components, such as lipids and DNA, might, therefore, result in subsequent cell death (Maness et al 1999).…”

Section: Introductionmentioning

confidence: 85%

Bactericidal Effects and Mechanisms of Visible Light-Responsive Titanium Dioxide Photocatalysts on Pathogenic Bacteria

Liou

Chang

2012

Arch. Immunol. Ther. Exp.

178

123

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This review focuses on the antibacterial activities of visible light-responsive titanium dioxide (TiO(2)) photocatalysts. These photocatalysts have a range of applications including disinfection, air and water cleaning, deodorization, and pollution and environmental control. Titanium dioxide is a chemically stable and inert material, and can continuously exert antimicrobial effects when illuminated. The energy source could be solar light; therefore, TiO(2) photocatalysts are also useful in remote areas where electricity is insufficient. However, because of its large band gap for excitation, only biohazardous ultraviolet (UV) light irradiation can excite TiO(2), which limits its application in the living environment. To extend its application, impurity doping, through metal coating and controlled calcination, has successfully modified the substrates of TiO(2) to expand its absorption wavelengths to the visible light region. Previous studies have investigated the antibacterial abilities of visible light-responsive photocatalysts using the model bacteria Escherichia coli and human pathogens. The modified TiO(2) photocatalysts significantly reduced the numbers of surviving bacterial cells in response to visible light illumination. They also significantly reduced the activity of bacterial endospores; reducing their toxicity while retaining their germinating abilities. It is suggested that the photocatalytic killing mechanism initially damages the surfaces weak points of the bacterial cells, before totally breakage of the cell membranes. The internal bacterial components then leak from the cells through the damaged sites. Finally, the photocatalytic reaction oxidizes the cell debris. In summary, visible light-responsive TiO(2) photocatalysts are more convenient than the traditional UV light-responsive TiO(2) photocatalysts because they do not require harmful UV light irradiation to function. These photocatalysts, thus, provide a promising and feasible approach for disinfection of pathogenic bacteria; facilitating the prevention of infectious diseases.

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Section: Introductionmentioning

confidence: 85%

Bactericidal Effects and Mechanisms of Visible Light-Responsive Titanium Dioxide Photocatalysts on Pathogenic Bacteria

Liou

Chang

2012

Arch. Immunol. Ther. Exp.

178

123

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“…Consequently, the development of highly efficient and low-cost antibacterial surfaces has been the object of many research works [1,2].…”

Section: Introductionmentioning

confidence: 99%

Single-stage in situ synthesis of silver nanoparticles in antibacterial self-assembled overlays

et al. 2012

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In this work, a novel single-stage process for in situ synthesis of Ag nanoparticles (NPs) using the layer-bylayer (LbL) technique is presented. The Ag NPs were formed into nanotextured coatings based on sequentially adsorbed poly(allylamine hydrochloride) (PAH) and SiO 2 NPs. Such highly porous surfaces have been used in the fabrication of highly efficient ion release films for applications such as antibacterial coatings. In this approach, the amino groups of the PAH acted as reducing agent and made possible the in situ formation of the Ag NPs. This reduction reaction occurred during the LbL process as the coating was assembled, without any further step after the fabrication and stabilization of the multilayer film. Biamminesilver nitrate was used as the Ag + ion source during the LbL process and it was successfully reduced to Ag NPs. All coatings were tested with gram-positive and gram-negative bacterial cultures of Escherichia coli, Staphylococcus aureus, and Lactobacillus delbrueckii showing an excellent antimicrobial behavior against these types of bacteria (more than 99.9% of killing efficiency in all cases).

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“…[91]. Eine Selektion von Bakterien mit Antibiotikaresistenzen bei Einsatz von richtig durchgeführten Flächendesinfekti-onsverfahren ist bislang nicht beobachtet worden [92,93,94,95].…”

Section: Häufigkeit Von Reinigung Bzw Desinfektion In Unterschiedlicunclassified

Anforderungen an die Hygiene bei der Reinigung und Desinfektion von Flächen

2004

Bundesgesundheitsbl - Gesundheitsforsch - Gesundheitsschutz

125

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Antiseptics and Disinfectants: Activity, Action, and Resistance

Cited by 3,916 publications

References 461 publications

Bactericidal Effects and Mechanisms of Visible Light-Responsive Titanium Dioxide Photocatalysts on Pathogenic Bacteria

Bactericidal Effects and Mechanisms of Visible Light-Responsive Titanium Dioxide Photocatalysts on Pathogenic Bacteria

Single-stage in situ synthesis of silver nanoparticles in antibacterial self-assembled overlays

Anforderungen an die Hygiene bei der Reinigung und Desinfektion von Flächen

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