Antistreptococcal treatment of guttate psoriasis: a controlled study

Doğan, Bilal; Karabudak, Özlem; Harmanyeri, Yavuz

doi:10.1111/j.1365-4632.2008.03663.x

Cited by 36 publications

(22 citation statements)

References 11 publications

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“…Based on these results, it has been suggested that therapies targeting the streptococcus can be beneWcial for patients with psoriasis. Although anti-streptococcal management, such as antibiotics and tonsillectomy, have frequently been advocated for patients with recurrent psoriasis [5,19], there is to date no good evidence that either intervention is beneWcial [6,15,16].…”

Section: Discussionmentioning

confidence: 99%

Clinical comparison of psoriasis in Korean adults and children: correlation with serum anti-streptolysin O titers

et al. 2010

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Psoriasis is a relatively common disorder in children and can be triggered by an upper respiratory tract infection. The aim of this study was to compare the clinical features of psoriasis in children and adult. In addition, we evaluated the relationship between anti-streptolysin O (ASO) titers and the clinical features of psoriasis. A total of 30 childhood psoriasis patients and 30 adult psoriasis patients were evaluated. Childhood psoriasis had a facial predominance when compared with the adult psoriasis. The childhood psoriasis patients with high ASO titers had guttate psoriasis more frequently than patients with normal ASO titers. In children with plaque-type psoriasis, psoriasis area and severity index score was increased in the high ASO titer group than normal ASO titer group. In conclusion, if the children with psoriasis show increased ASO titer, the physician should pay attention to the worsening of the psoriasis. Furthermore, early treatment of streptococcal infections might be beneWcial in childhood psoriasis.

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Section: Discussionmentioning

confidence: 99%

Clinical comparison of psoriasis in Korean adults and children: correlation with serum anti-streptolysin O titers

et al. 2010

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“…Penicillin, Makrolidantibiotika (Erythromycin, Roxithromycin, Clarithromycin) alleine oder in Kombination mit Rifampicin und bestanden in der Regel in einer Kurzzeittherapie von 10-14, maximal 30 Tagen. Während die offenen, unkontrollierten Studien durchaus eine Besserung der Psoriasis unter Antibiotikatherapie sowohl bei akut-exanthematischer als auch chronisch-stationärer Psoriasis beobachteten, war bei den beiden kontrollierten Studien kein Einfluss auf den Krankheitsverslauf nachweisbar [9,22,36,37,42,45,47,58]. In einer unkontrollierten Studie wurde der Einfluss einer Dauertherapie mit Depotpenicillin an 30 Patienten untersucht.…”

Section: Antibiotische Therapie Und Psoriasisunclassified

Bedeutung von Streptokokken für die Psoriasispathogenese

Prinz

2009

Hautarzt

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Infections with Streptococcus pyogenes are highly relevant among the environmental factors that contribute to first onset or relapses of psoriasis in predisposed individuals. Streptococcal angina or pharyngitis, but also perianal streptococcal dermatitis, vulvovaginitis or balanoposthitis are potential causes. Several mechanisms such as molecular mimicry or superantigens may be involved. Many patients develop a chronic streptococcal infection or colonization that may result from the ability of streptococci for intracellular uptake and persistence in epithelial cells. Whether and under what conditions a curative treatment of streptococcal infection by tonsillectomy or antibiotic treatment may affect the course of psoriasis, as proposed by several observations, needs to be determined in more detail by clinical trials.

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“…This could be linked again with a better prognosis of patients with AGP in acute flares. Clinical studies suggest that a clear history of pharyngitis is presented in 19-82% and serological evidence in 54-93% [24][25][26] . A previous study found that patients with elevated ASLO titers had a better clinical course [5] .…”

Section: Discussionmentioning

confidence: 99%

“…We did not routinely perform pharyngeal cultures or determine streptococcal antibodies in patients with AGP because most of them were cured or being treated when attending our outpatient clinic. Only patients with symptoms of pharyngitis were prescribed antibiotics as no benefits of adding antibiotics to the treatment of AGP without previous pharyngitis have been demonstrated [26] .…”

Section: Discussionmentioning

confidence: 99%

Phototherapy with Narrow-Band UVB in Adult Guttate Psoriasis: Results and Patient Assessment

Fernández‐Guarino¹,

Aboín-González²,

Velázquez³

et al. 2016

Dermatology

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Background: Acute guttate psoriasis (AGP) is a distinctive clinical entity with good response to treatment with narrow-band ultraviolet B (NB-UVB). Objective: To investigate the results of NB-UVB phototherapy in adult patients with adult guttate psoriasis. Material and Methods: We carried out a prospective, open, and observational study. Patients over 18 years with more than 5% of body surface area affected were included. The PASI was assessed prior to and after treatment. The follow-up period was 18 months. After treatment, patients completed a simple questionnaire to assess their overall impression of the treatment. Results: The 67 adult patients with AGP included in this study had an initial PASI of 8.55 (SD 5.03). Patients were treated with a mean of 19.9 sessions (SD 13.5) and mean doses of 14 mJ/cm² (SD 10.5). Of the 67 patients, 52 achieved PASI90 with 96.15% of PASI reduction, and of these, 46 (88%) maintained PASI90 during the 18 months of follow-up. Patients were very satisfied with the treatment. Discussion: AGP is a defined clinical entity with a variable course. Phototherapy with NB-UVB appears to be a very good option for treatment of AGP because of the good results obtained and patient satisfaction.

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Antistreptococcal treatment of guttate psoriasis: a controlled study

Abstract: There was no statistically significant improvement in streptococcus associated guttate psoriasis with or without a course of oral penicillin or erythromycin.

Cited by 36 publications

References 11 publications

Clinical comparison of psoriasis in Korean adults and children: correlation with serum anti-streptolysin O titers

Clinical comparison of psoriasis in Korean adults and children: correlation with serum anti-streptolysin O titers

Bedeutung von Streptokokken für die Psoriasispathogenese

Phototherapy with Narrow-Band UVB in Adult Guttate Psoriasis: Results and Patient Assessment

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