Antithrombotic effect of thiopurinol

Curcumin as “Curecumin”: From kitchen to clinic

“…Throughout the Orient, it has traditionally been used to good therapeutic effect, particularly as an anti-inflammatory [12], and many of its therapeutic effects have been confirmed by modern scientific research. Such effects include antioxidant [27], anti-inflammatory [24,28,29], anticarcinogenic and antimicrobial [30][31][32], hepatoprotective [32], thrombosuppressive [33], cardiovascular (i.e., as protection against myocardial infarction) [29,34,35], hypoglycemic [36][37][38], and antiarthritic (i.e., as protection against rheumatoid arthritis) [39], The most compelling and key rationale for the continuing traditional therapeutic use of curcumin is its extremely good safety profile. To date, no studies in either animals [40,41] or humans [42] have discovered any toxicity associated with the use of curcumin, and it is clear that curcumin is not toxic even at very high doses.…”

Orthorhombic form of thiopurinol: 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-thione

“…Both inhibit ribonucleic acid biosynthesis thus affecting protein synthesis (Looker et al, 1986). Both are potent inhibitors of xanthine oxidase (Robins et al, 1985) and are effective antigout (Feigelson, Davidson & Robins, 1957), antiparasitic (Nelson, Bugge, Elion, Berens & Marr, 1979) and antithrombotic (Dikshit, Srivastava, Kar & Srimal, 1987;Srivastava, Mishra, Pratap, Bhakuni & Srimal, 1989) agents. The structure and intermolecular interactions of these compounds are, therefore, important in considering their interactions with biological macromolecules.…”

Evaluation of Turmeric (Curcuma longa L.) Genotypes for Growth, Yield and Quality Traits under Northern Plains of India

“…Curcumin also protects the liver from toxic compound. It acts as anticoagulant by inhibiting collagen and adrenaline induced platelet aggregation (Srivastava et al, 1985). It possesses wound healing properties and has antifungal effects.…”