Antitumor Activity and Hematopoietic Response of a β-Glucan Extracted from the Mushroom Sparassis crispa (Wulf.) Fr.

Ohno, Naohito; Harada, Toshie; Masuzawa, Shinya; Miura, Noriko N.; Adachi, Yoshiyuki; Nakajima, Mitsuhiro; Yadomae, Toshiro

doi:10.1615/intjmedmushr.v3.i2-3.1090

Cited by 3 publications

(4 citation statements)

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“…(300 mg per day) was given orally to several cancer patients after one course of lymphocyte transfer immunotherapy. Performance status of 14 cases were monitored after several months, and 9 cases were improved (61,62). In China, several preparations from Hericium caput-medusae (Bull.…”

Section: Immunomodulators From Mushrooms and Adjuvant Tumor Therapymentioning

confidence: 99%

The Pharmacological Potential of Mushrooms

Lindequist

Niedermeyer

Jülich

2005

Evidence-Based Complementary and Alternative Medicine

834

595

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Section: Immunomodulators From Mushrooms and Adjuvant Tumor Therapymentioning

confidence: 99%

The Pharmacological Potential of Mushrooms

Lindequist

Niedermeyer

Jülich

2005

Evidence-Based Complementary and Alternative Medicine

834

595

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“…질로서 항암효과가 잘 알려진 아가리쿠스버섯(100 g당 11.3 g)보다 β-1,3-glucan의 함량이 약 3배 이상이나 높은 것으 로 알려져 있다 (13). 이러한 꽃송이버섯은 새로운 약용버섯 으로 관심을 끌고 있다.…”

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Lipolytic Effect of Sparassis crispa Extracts in Differentiated 3T3-L1 Cells and High Fat Diet-induced Obese Mice

Lee¹,

Park

Um³

et al. 2012

Journal of the Korean Society of Food Science and Nutrition

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The purpose of this study was to investigate whether water extracts of Sparassis crispa (SC) have anti-obesity effects. Treatment of mature adipocytes with SC caused a decrease in lipid accumulation (assessed by Oil Red O staining) and an increase in glycerol release. Mice were induced to obesity by a high fat diet (45% fat in total kcal) and experimental groups were treated with two different dosages of SC extracts, a low SC (LSC, 100 mg/kg/day) or high SC (HSC, 300 mg/kg/day). SC extracts were administered by gavages for 10 weeks in the experimental groups, while the control group was fed with distilled water. The body weight gain of mice fed SC was significantly reduced (11.88% lower in LSC, 14.54% lower in HSC) compared to the control group. Additionally, there were significantly reduced serum levels of triglycerides (13.57% lower in LSC, 19.46% lower in HSC), total cholesterol (32.22% lower in LSC, 24.67% lower in HSC) and glucose (28.85% lower in LSC, 25.82% lower in HSC) in mice fed SC compared to the control group. Hepatic triglycerides in mice fed SC were lower (9.68% lower in LSC, 14.24% lower in HSC) than the control group and total cholesterol levels were also lower in mice fed SC (38.72% lower in LSC, 35.20% in HSC). These results demonstrate that the water extract of SC may enhance lipolysis and up-regulate the expression of lipolytic enzymes in vitro and reduce body weight in vivo. These significant effects were found for both low and high doses of SC treatment, and suggest SC can be used as potential therapeutic substances for the prevention and treatment of obesity.

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“…Indeed, S. crispa contains highly physiological active substances (e.g., β-glucan, phenolic compounds, chloroform extract, and some antibiotic compounds) that can support a healthy level of blood-sugar and recovery of the normal cellular immunization [ 3 ]. The beneficial effects have been demonstrated by anti-diabetic, anti-tumor, anti-inflammatory, anti-fungal, and anti-oxidant activities [ 1 , 3 , 11 , 20 , 47 ]; almost all of the typical therapeutic effects of S. crispa showed significant differences, relative to the control groups.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have indicated, through tests on either mice or human cell lines, that S. crispa is a potential natural source of medicinal ingredients that can contribute to the limitations and even prevention of human disease (e.g., cancer, allergies, and especially diabetic disease) [ 12 , 13 , 19 , 20 ] However, in individual studies, scientists have not focused on the overall assessments of the benefits of S. crispa in human health as a systematic review. Thus, this study reviewed randomized and controlled trials, also conducted a systematic review and meta-analysis to evaluate the statistically significant benefits of S. crispa in therapeutic approaches.…”

Section: Introductionmentioning

confidence: 99%

Effects of Sparassis crispa in Medical Therapeutics: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Ngoc

Lee

2018

IJMS

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In this study, we investigated the therapeutic potential and medical applications of Sparassis crispa (S. crispa) by conducting a systematic review of the existing literature and performing a meta-analysis. The original efficacy treatment of the mushroom extract is considered primarily and searched in electronic databases. A total of 623 articles were assessed, 33 randomized controlled experiments were included after the manual screening, and some papers, review articles, or editorials that did not contain data were excluded. A comparative standard means difference (SMD) and a funnel plot between control and S. crispa groups were used as parameters to demonstrate the beneficial effects of S. crispa for diabetes and cancer treatment, as well as anti-inflammatory, anti-fungal and antioxidant activities. The meta-analysis was carried out using Review Manager 5.1 software. Although for therapeutic diabetes there was heterogeneity in the subgroup analysis (I2 = 91.9%), the overall results showed statistically significant SMDs in major symptoms that decreased serum insulin levels (SMD = 1.92, 95% CI (1.10, 2.75), I2 = 0%), wound rates (SMD = 3.55 (2.56, 4.54), I2 = 40%) and contributions to an increase in nutrient intake content (SMD = 0.32 (−0.15, 0.78), I2 = 0%). Simultaneously, the study confirmed the utility of S. crispa treatment in terms of not only anti-cancer activity (reduction of tumor activity and survival of cancer cells I2 = 42 and 34%, respectively) but also anti-inflammatory, anti-fungal and antioxidant activities (I2 = 50, 44, and 10%, respectively). Our findings suggest that S. crispa extracts are useful for prevention and treatment of human diseases and might be the best candidates for future medicines.

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Antitumor Activity and Hematopoietic Response of a β-Glucan Extracted from the Mushroom Sparassis crispa (Wulf.) Fr.

Cited by 3 publications

References 0 publications

The Pharmacological Potential of Mushrooms

The Pharmacological Potential of Mushrooms

Lipolytic Effect of Sparassis crispa Extracts in Differentiated 3T3-L1 Cells and High Fat Diet-induced Obese Mice

Effects of Sparassis crispa in Medical Therapeutics: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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