Antitumor Effect of Various Phytochemicals on Diverse Types of Thyroid Cancers

Shin, Hyun Dae; Hwang, Kyung‐A; Choi, Kyung‐Chul

doi:10.3390/nu11010125

Cited by 38 publications

(31 citation statements)

References 86 publications

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“…Isoflavones (genistein and daidzein) are abundant in soybeans derivative products and are known as RTK inhibitors, targeting the epidermal growth factor (EGF) and interfering with the cell proliferation, migration, and invasion mechanism [29]. Most of the studies on isoflavones are related to the antitumoral effects in hormonal dependent-cancer [19].…”

Section: Anticancer Effects Of Flavonoids In Lung Cancermentioning

confidence: 99%

Progress in Research on the Role of Flavonoids in Lung Cancer

Zănoagă

Braicu

Jurj

et al. 2019

IJMS

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Lung cancer is the leading cause of cancer deaths worldwide. Therefore, for the prevention, diagnosis, prognosis and treatment of lung cancer, efficient preventive strategies and new therapeutic strategies are needed to face these challenges. Natural bioactive compounds and particular flavonoids compounds have been proven to have an important role in lung cancer prevention and of particular interest is the dose used for these studies, to underline the molecular effects and mechanisms at a physiological concentration. The purpose of this review was to summarize the current state of knowledge regarding relevant molecular mechanisms involved in the pharmacological effects, with a special focus on the anti-cancer role, by regulating the coding and non-coding genes. Furthermore, this review focused on the most commonly altered and most clinically relevant oncogenes and tumor suppressor genes and microRNAs in lung cancer. Particular attention was given to the biological effect in tandem with conventional therapy, emphasizing the role in the regulation of drug resistance related mechanisms.

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Section: Anticancer Effects Of Flavonoids In Lung Cancermentioning

confidence: 99%

Progress in Research on the Role of Flavonoids in Lung Cancer

Zănoagă

Braicu

Jurj

et al. 2019

IJMS

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“…Papillary and follicular thyroid carcinoma are the most common types of DTCA [120]. Undifferentiated medullary and anaplastic thyroid cancer have, however, a less favorable prognosis than that for DTCA ( [121].…”

Section: Thyroid Status Imbalance Promotes Vfmentioning

confidence: 99%

Pro-Arrhythmic Signaling of Thyroid Hormones and Its Relevance in Subclinical Hyperthyroidism

Tribulová

Kurahara

Hlivák

et al. 2020

IJMS

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A perennial task is to prevent the occurrence and/or recurrence of most frequent or life-threatening cardiac arrhythmias such as atrial fibrillation (AF) and ventricular fibrillation (VF). VF may be lethal in cases without an implantable cardioverter defibrillator or with failure of this device. Incidences of AF, even the asymptomatic ones, jeopardize the patient’s life due to its complication, notably the high risk of embolic stroke. Therefore, there has been a growing interest in subclinical AF screening and searching for novel electrophysiological and molecular markers. Considering the worldwide increase in cases of thyroid dysfunction and diseases, including thyroid carcinoma, we aimed to explore the implication of thyroid hormones in pro-arrhythmic signaling in the pathophysiological setting. The present review provides updated information about the impact of altered thyroid status on both the occurrence and recurrence of cardiac arrhythmias, predominantly AF. Moreover, it emphasizes the importance of both thyroid status monitoring and AF screening in the general population, as well as in patients with thyroid dysfunction and malignancies. Real-world data on early AF identification in relation to thyroid function are scarce. Even though symptomatic AF is rare in patients with thyroid malignancies, who are under thyroid suppressive therapy, clinicians should be aware of potential interaction with asymptomatic AF. It may prevent adverse consequences and improve the quality of life. This issue may be challenging for an updated registry of AF in clinical practice. Thyroid hormones should be considered a biomarker for cardiac arrhythmias screening and their tailored management because of their multifaceted cellular actions.

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“…Therefore, resveratrol holds the promise that it can protect the heart and fight the cancer at the same time. Since the anticancer properties of resveratrol have been discussed in a number of excellent reviews [27,104,105,106], we will focus here on the studies that demonstrated an additive and/or synergistic effect when resveratrol is combined with an anthracycline both in vitro (Table 3) and in vivo (Table 4).…”

Section: Anthracyclinesmentioning

confidence: 99%

Leveraging the Cardio-Protective and Anticancer Properties of Resveratrol in Cardio-Oncology

2019

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Cardio-oncology is a clinical/scientific discipline which aims to prevent and/or treat cardiovascular diseases in cancer patients. Although a large number of cancer treatments are known to cause cardiovascular toxicity, they are still widely used because they are highly effective. Unfortunately, therapeutic interventions to prevent and/or treat cancer treatment-induced cardiovascular toxicity have not been established yet. A major challenge for such interventions is to protect the cardiovascular system without compromising the therapeutic benefit of anticancer medications. Intriguingly, the polyphenolic natural compound resveratrol and its analogs have been shown in preclinical studies to protect against cancer treatment-induced cardiovascular toxicity. They have also been shown to possess significant anticancer properties on their own, and to enhance the anticancer effect of other cancer treatments. Thus, they hold significant promise to protect the cardiovascular system and fight the cancer at the same time. In this review, we will discuss the current knowledge regarding the cardio-protective and the anticancer properties of resveratrol and its analogs. Thereafter, we will discuss the challenges that face the clinical application of these agents. To conclude, we will highlight important gaps of knowledge and future research directions to accelerate the translation of these exciting preclinical findings to cancer patient care.

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Antitumor Effect of Various Phytochemicals on Diverse Types of Thyroid Cancers

Cited by 38 publications

References 86 publications

Progress in Research on the Role of Flavonoids in Lung Cancer

Progress in Research on the Role of Flavonoids in Lung Cancer

Pro-Arrhythmic Signaling of Thyroid Hormones and Its Relevance in Subclinical Hyperthyroidism

Leveraging the Cardio-Protective and Anticancer Properties of Resveratrol in Cardio-Oncology

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