Antitumour activity of dopa, dopamine, noradrenalin or adrenalin and their reaction with nucleic acids

Formation of Some Reductones on the Reaction ofl-Ascorbic Acid with Sodium Nitrite

“…The cleavage of DNA with reductones was confirmed. 9 ,IO) Recently, ASA as a typical reductone has been suggested ll ,IZ) and discussed l3 ) as an anti-cancer agent.…”

Mutagenic action of triose reductone and ascorbic acid on Salmonella typhimurium AT 100 strain.

“…To clarify their functions is one of the most important problems from the viewpoint of food manufacturing, but this has not been done except in the case of several kinds of reductones. Our preceding studies have already demonstrated that some reductones possessed antitumoric potency to sarcoma-180 and nucleic acid-breaking activity, and that their actions were brought about by the reductone structures (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Cupric ion promoted the actions of reductones.…”

Breakage of Chromosomal DNA with Aromatic Reductones

“…9 ) Cleavage of chromosomal DNA by these reductones is derived from direct chemical function of their enediol groups. A mechanism of the cleavage of the phosphodiester backbone in DNA has been proposed.1O) By use of the most active aromatic reductone for DNA cleavage, adrenaline, the cleaving process of chromosomal DNA was examined more precisely.…”