Antiulcer activities of D-penicillamine copper complexes

Abstract

A comparison of the antiuleer activities of the polymeric cuprous, cupric disulfide and mixed valence D-penieillamine copper eomplexes in the Shay rat are presented. The data support the conclusion that these complexes may be less toxic and more effective than the parent compound in the therapy of arthritic diseases and/or ulcers.

Prophylactic Role of a Herbomineral Drug “Thamira Parpam” Against Cysteamine-Induced Oxidative Stress in Liver and Duodenum of Rats

“…A recent study on Cu-containing complexes has shown increased antiulcer activity [7]. Also, a comparable study of copper complexes in the sham rats has shown that those are less toxic and effective than parent compound in the therapy of arthritis and/or ulcers [8]. In Siddha system of medicine, copper-based herbomineral formulation is said to be effective against gastric ulcer, nodular inflammation, respiratory diseases, hepato-splenomegaly, and eye disorders [9].…”

Dinuclear CuIcomplexes of pyridyl-diazadiphosphetidines and aminobis(phosphonite) ligands: synthesis, structural studies and antiproliferative activity towards human cervical, colon carcinoma and breast cancer cells

“…Copper is an essential trace metal for living organisms and plays a major role in several enzymatic activities, in particular redox reactions which have an influence on the antioxidant system of the organism. 24 The medicinal properties of copper complexes in anti-inflammatory, antiarthritic, antiulcer and anticonvulsant diseases including anticancer properties [25][26][27][28][29][30][31] are also well documented. Due to the selective permeability of cancer cell membranes to copper complexes and their strict regulation on intracellular concentration encouraged the synthesis of copperbased compounds as probable antiproliferative agents with relatively less severe side effects than the present standard anticancer drugs.…”

Dinuclear Copper(I) Complexes Containing Cyclodiphosphazane Derivatives and Pyridyl Ligands: Synthesis, Structural Studies, and Antiproliferative Activity toward Human Cervical and Breast Cancer Cells

“…Copper complexes are potential reagents for the cleavage of DNA both oxidatively , and hydrolytically. − Many of these complexes are found to be anti-inflammatory, antiarthritic, antiulcer, anticonvulsant, and antitumor agents . The selective permeability of cancer cell membranes to copper complexes and their strict regulations of the intracellular concentration have encouraged the synthesis of copper-based drugs as potential anticancer agents that are anticipated to have less severe side effects than standard anticancer drugs.…”

“…The selective permeability of cancer cell membranes to copper complexes and their strict regulations of the intracellular concentration have encouraged the synthesis of copper-based drugs as potential anticancer agents that are anticipated to have less severe side effects than standard anticancer drugs. Several copper(I) complexes containing either pyridyl-type ligands such as 1,10-phenanthraline or mono- and bis(phosphine) ligands were screened for their anticancer activity, − and some have shown good antiproliferative activity toward cancer cells.…”