Antiulcer and Cluster of Differentiation-31 Properties of Cucumis melo L. on Indomethacin-Induced Gastric Ulceration in Male Wistar Rats

Adebayo-Gege, Grace; Okoli, Bamidele Joseph; Oluwayinka, P. O; Ajayi, Ayodeji Folorunsho; Mtunzi, Fanyana M.

doi:10.1007/978-3-030-20283-5_29

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…This result conforms to the work performed by Adebayo-Gege et al [9,10], where aqueous extract of cucumis melo decrease total gastric acidity during the NSAID induced gastric ulceration. The ability of Cucumis melo extract (CUM) to lessen overall stomach acidity accounts for its anti-secretory characteristics as well as its role in repairing the mucosal membrane's altered hydrophobicity and diminished protective ability [9,10]. This is further explained by the gross morphology and H&E to corroborate that the methanol extract of Cucumis melo inhibit the damage caused by pyloric ligation induced gastric ulceration .…”

Section: Discussionsupporting

confidence: 93%

“…The cucurbit (cucumis melo) is a member of the cucurbitaceae family. Numerous experimental investigations have been conducted to assess citrullus lanatus's antiulcer and gastroprotective properties [8,9,10] .This study evaluated the effectiveness and protective functions of Cucumis melo against stomach ulcers caused by pyloric ligation in male Wistar rats.…”

Section: Introductionmentioning

confidence: 99%

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Protective functions of methanol extract of Cucumis Melo (L. INODOROUS) seeds on Pyloric ligation induced gastric ulceration in male Wistar rats

Adebayo-Gege¹

2023

Magna Sci. Adv. Res. Rev.

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Accumulation of gastric acid and Reactive oxygen species (ROS) have been associated with development the of gastric ulceration in pyloric ligation, Cucumis melo Seeds is said to be possess a strong antioxidant. Thus this study evaluated the antiulcer activities of Methanol extract of Cucumis melo seeds on Pyloric ligation induced gastric ulceration in male Wistar rats. Thirty Male Wistar rats (n=5, 150-200g) rats were randomly groups in to five groups; A (control),B(Pyloric ligation induced gastric ulceration(PYL),C,D,E were administered with 50mg/kg,100mg/kg,200mg methanol extract of Cucumis melo seeds + PYL for 21 days prior to to pyloric ligation induction under ketamine anesthesia(60mg/kg). The animals were sacrifice after six hours, total gastric acidity was measured by titrimetric method, ulcer score and index was assessed, hematological parameters was measure using auto-analyzer while MDA,Catalase and protein was determined by spectrophotometry with histology analysis. Upon Pyloric ligation, the total gastric acidity, ulcer score ,index, lipid peroxidation(MDA level) was increased, while there was a decrease in the catalase, protein level and hematological parameters, with damages on the gastric mucosa . Cucumis melo seed extract reverses these changes induced by pyloric ligation. In conclusion, the gastric mucosa was disrupted as a result of accumulation acid, increases in oxidation after pyloric ligation with decrease in antioxidant and hematological parameters, methanol extract of Cucumis Melo provides a protection against the pyloric ligation induced gastric ulceration.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Protective functions of methanol extract of Cucumis Melo (L. INODOROUS) seeds on Pyloric ligation induced gastric ulceration in male Wistar rats

Adebayo-Gege¹

2023

Magna Sci. Adv. Res. Rev.

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“…Vitamin B2 (Riboflavin) is a water soluble vitamin (6) which present in a wide sources of foods (7) . Such vitamin is important precursor for two active cofactors which are flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) which participate in a wide range of redox reactions which in turn protect the body against variety of oxidative stress conditions (8) .…”

Section: Introductionmentioning

confidence: 99%

Effects of Two Different Doses of Vitamin B2 and a Single Dose of Vitamin B12 Against Cyclophosphamide Induced Nephrotoxicity

2020

MLU

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Cyclophosphamide, a medication that is used for the treatment of different types of cancer; however its' use associated with numerous adverse effects. Vitamin B2 and vitamin B12 suggested having nephroprotective effect. This work is designed to investigate the nephroprotective effect of both vitamins against cyclophosphamide induced nephrotoxicity. One hundred adult rats of both sexes were used in this study. The animals were randomly enrolled into ten groups of 10 rats each. On day eight, animals were sacrificed and blood collected for the measurement of serum superoxide dismutase 1, glutathione peroxidase; and kidney extracted for histological examination. Vitamin B2 and vitamin B12 significantly (P<0.05) increase superoxide dismutase 1, glutathione peroxidase; and the combination of vitamins produce significant (P<0.05) increase in superoxide dismutase 1 and glutathione peroxidase compared to the corresponding levels in other groups; and improve histopathological changes compared to cyclophosphamide-treated rats. In conclusion both vitamins may have nephroprotective effects against cyclophosphamide-induced nephrotoxicity.

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Molecular docking and anti-ulcerative potential of Cucumis (L. Inodorous) on ibuprofen induced gastric ulceration in male wistar animals

Adebayo-Gege¹,

Uthman²,

Adams³

et al. 2023

Biomedicine & Pharmacotherapy

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Antiulcer and Cluster of Differentiation-31 Properties of Cucumis melo L. on Indomethacin-Induced Gastric Ulceration in Male Wistar Rats

Cited by 5 publications

References 30 publications

Protective functions of methanol extract of Cucumis Melo (L. INODOROUS) seeds on Pyloric ligation induced gastric ulceration in male Wistar rats

Protective functions of methanol extract of Cucumis Melo (L. INODOROUS) seeds on Pyloric ligation induced gastric ulceration in male Wistar rats

Effects of Two Different Doses of Vitamin B2 and a Single Dose of Vitamin B12 Against Cyclophosphamide Induced Nephrotoxicity

Molecular docking and anti-ulcerative potential of Cucumis (L. Inodorous) on ibuprofen induced gastric ulceration in male wistar animals

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