Antiulcerogenic activity of Alchornea castaneaefolia: Effects on somatostatin, gastrin and prostaglandin

Hiruma-Lima, Clélia Akiko; Calvo, Tamara Regina; Rodrigues, Clenilson Martins; Andrade, Fábio Donizete Pezzuto; Vilegas, Wagner; Brito, Alba Regina Monteiro Souza

doi:10.1016/j.jep.2005.09.007

Cited by 69 publications

(48 citation statements)

References 40 publications

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“…Indomethacin is known to cause ulcer especially in an empty stomach and mostly on the glandular (mucosal) part of the stomach by inhibiting prostaglandin synthetase through the cycloxygenase pathway [13] . Prostaglandins function to protect the stomach from injury by stimulating the secretion of bicarbonate and mucus, maintaining mucosal blood flow and regulating mucosal turn over and repair [17] . Suppression of prostaglandins synthesis by indomethacin results in increased susceptibility of the stomach to mucosal injury and gastroduodenal ulceration.…”

Section: Discussionmentioning

confidence: 99%

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Antiplasmodial and antiulcer activities of Melanthera scadens

Okokon

Etebong

Udobang

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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Section: Discussionmentioning

confidence: 99%

“…Swiss albino mice (17)(18)(19)(20)(21)(22)(23)(24) g) and rats (120-145 g) of both sexes were used for these experiments. They were obtained from University of Uyo Animal House.…”

Section: Animalsmentioning

confidence: 99%

Antiplasmodial and antiulcer activities of Melanthera scadens

Okokon

Etebong

Udobang

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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“…One study showed antiinflammatory activity in an acetate fraction obtained from the methanol extract of the leaves of A. castaneaefolia (Lopes et al, 2005). Hiruma-Lima et al (2006) showed that a compound obtained from this species had antiulcerogenic activity.…”

Section: Introductionmentioning

confidence: 99%

Mutagenicity of two species of the genus Alchornea measured by Salmonella microsome assay and micronucleus test

Santos¹,

Calvo²,

Cólus³

et al. 2010

Rev. bras. farmacogn.

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Some species of the plant genus Alchornea (family Euphorbiaceae) are widely used in popular medicine, mainly in South America and in Africa. Several kinds of biological activity have been seen in the species: antioxidant, antifungal, anti-inflammatory, antibacterial, cytotoxic against tumor cell lines and inhibitory to the replication of HIV-1 and HIV-2. In Brazil, the species Alchornea castaneaefolia Willd. A. Juss. and Alchornea glandulosa Poepp. & Endl. are used by the local population to treat rheumatism, arthritis and muscular pains. In view of the popular use of these plants as medicines and the potential risks from their consumption, we assessed the mutagenic potential of chloroform and methanol extracts of the leaves of these plant species, employing the in vivo micronucleus test and the Ames assay. The data obtained showed that the chloroform extracts were not mutagenic. The methanol extract of A. castaneaefolia was mutagenic to strain TA98 of Salmonella typhimurium and the methanol extract of A. glandulosa to strains TA98 and TA97a. The methanol extracts of both species of Alchornea were mutagenic in vivo at the largest dose employed. The probable mutagenic agents involved were the aglycone quercetin and amentoflavone, present in both species.

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“…6 In contrast, other species of this genus already have been subjects of pharmacological studies: Alchornea cordifolia presented an anti-inflammatory property, whereas Alchornea castaneaefolia and Alchornea glandulosa exhibited an anti-ulcer action. [7][8][9] Ebi 10 determined that methano-lic extract (ME) of A. cordifolia also showed antimicrobial activity against Pseudomonas aeruginosa, Bacillus subtilis, and Escherichia coli.…”

Section: Introduction Pmentioning

confidence: 99%

“…It is notable that our previous work with A. castaneaefolia extract also produced an increase in PGE 2 production. 8 However, more interesting results were obtained in the group of animals treated with EAF and pretreated with indomethacin (an inhibitor of cyclooxygenase enzyme). Results displayed in Figure 3 show that EAF was able to maintain a high PGE 2 level despite administration of indomethacin.…”

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confidence: 99%

Brazilian Medicinal Plant Acts on Prostaglandin Level andHelicobacter pylori

Lima

Calvo

Silva

et al. 2008

Journal of Medicinal Food

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Among the current treatment strategies for the peptic ulcer patient with Helicobacter pylori infection, the method of choice is triple therapy based on the concurrent use of proton inhibitors and two antibiotics. Alchornea triplinervia is a medicinal plant commonly used by people living in the Cerrado region of Brazil to treat gastrointestinal ulcers. In the present work we proposed therapy based on this medicinal plant that presents effective gastroprotective action with antibiotic effects. Oral pretreatment with methanolic extract (ME) of A. triplinervia in rats and mice decreased the gastric injuries induced by ethanol and HCl/ethanol. Increasing the dose reduced the gastroprotective effects of ME on the gastric lesions induced by nonsteroidal anti-inflammatory drug. After pylorus ligature of mice, oral administration of ME induced a decrease not only in total acid but also in the ulcer index. We also observed that ME displayed antibacterial activity against H. pylori. Liquid-liquid separation of ME indicated that active constituents responsible for the gastroprotective action are concentrated in the ethyl acetate fraction (EAF) (50% protection) rather than in the aqueous fraction, which did not induce significant gastroprotection at the same dose (100 mg/kg). EAF induced an increase of gastric mucosa prostaglandin (PG) E 2 levels, which remained high even after previous administration of indomethacin. The phytochemical profile of ME revealed that EAF contains mainly flavonoids. In conclusion, all these results suggest that ME did not show acute toxicity, but exhibited an antisecretory property, anti-H. pylori effect, and gastroprotective action. The observed effect did not involve the participation of nitric oxide or endogenous sulfhydryl groups. However, EAF showed a more efficient gastroprotective effect than ME at a lower dose and protected the gastric mucosa by increasing PGE 2 .

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Antiulcerogenic activity of Alchornea castaneaefolia: Effects on somatostatin, gastrin and prostaglandin

Cited by 69 publications

References 40 publications

Antiplasmodial and antiulcer activities of Melanthera scadens

Antiplasmodial and antiulcer activities of Melanthera scadens

Mutagenicity of two species of the genus Alchornea measured by Salmonella microsome assay and micronucleus test

Brazilian Medicinal Plant Acts on Prostaglandin Level andHelicobacter pylori

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