Antiulcerogenic and antidiarrhoeal potentials of methanolic extract of &lt;i&gt;Pausinystalia macroceras&lt;/i&gt; stem-bark in rats

Nwafor, Paul A.; Jacks, T. W.; Ekanem, AU; Poh, Ching Fidelis

doi:10.4314/njnpm.v9i1.11839

Cited by 7 publications

(8 citation statements)

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“…The study has shown that medicinal ingredients abound in our plants which may the leaves, fruits, stems, roots need be explored and not total dependent on orthodox drugs which not only be effective as herbal plants but with side effects and complications. Nwafor et al (2005); Setiawan et al (2001); Williamson et al (1996) and Sofowora (1982). Hypoglycemic properties as indicator have proved very sensitive in drugs and food screening in this study.…”

Section: Discussionmentioning

confidence: 99%

Periodic Validation of High Antidiabetic Potentials of Unripe Plantain in Comparison with Glibenclamide and Fansidar

A.¹

2012

American Journal of Pharmacology and Toxicology

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Problem statement: The antidiabetic potentials of aqueous extract of musa paradisciaca (unripe plantain fruit) were investigated in alloxan induced diabetic rats. The extract at a dosage of 120 mg kg −1 produced a significant (p<0.001) reduction in glucose level by 85% on day 7, 78% on day 14, 64% on day 21 and 44% on day 28. Approach: The extract at the dosage of 80 mg kg −1 produced a significant (p<0.01) reduction in glucose concentration by 86% on day 7, 79% on day 14 64%, day 21 and 458% on day 28. With 40 mg kg −1 glucose level was 83% on day 7, 75% on day 14, 68%, day 21 and 58, 64% on day 21 and 58% on day 28. Results: Fansidar at the calculated average animal dosage 9-22.5 mg kg −1 from that of man produced a significant (p<0.01) reduction in glucose concentration by 81% on day 7 71% on day 14, 58% on day 21 and on day 28 a shooting to 111%. Comparing the fasting blood glucose levels of extract and fansidar with known antidiabetic drug; Gliben clamide of 6.75 mg kg −1 had the following on day 7; it was 96, 86% on day 14, 45% on day 21 and 81% on day 28. Conclusion: It is concluded that extract of unripe plantain fruit showed high antidiabetic properties than glibenclamide a known potent antidiabetic drug and fansidar is also demonstrated a good degree of antidabetic potentials.

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Section: Discussionmentioning

confidence: 99%

Periodic Validation of High Antidiabetic Potentials of Unripe Plantain in Comparison with Glibenclamide and Fansidar

A.¹

2012

American Journal of Pharmacology and Toxicology

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“…This was studied in rats using the method of Nwafor et al [9]. Animals were fasted for 18 h but allowed free access to water.…”

Section: Effect On Castor Oil-induced Diarrhoeamentioning

confidence: 99%

Croton zambesicus Root Extract Exert Laxative Effect in Rats

Okokon

Bassey

Nyong

et al. 2020

AJOB

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Background: Croton zambesicus Muell Arg. (Euphorbiaceace) is a medicinal plant used traditionally in the treatment of some ailments. Aim: The root extract of Croton zambesicus was evaluated for effect on the gastrointestinal tract (GIT). Materials and Methods: The root extract of C. zambesicus (27-81 mg/kg) was investigated for laxative effect in rats using different experimental models to study its effect on the GIT. Results: The extract was found to significantly increase the frequency and output of faecal matters in rats in all the experimental models studied. Conclusion: The findings of this study show that the root extract of C. zambesicus has a significant laxative effect and this supports its use in ethnomedicine for the treatment of gastrointestinal tract disorders.

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“…Schum.) Pierre ex Beille [ 28 ]. While plant extracts that perform through healing activity includes Quassia amara L. [ 29 ], Matricaria chamomilla L. [ 30 ] and D-002 (mixture of higher aliphatic primary alcohols isolated from beeswax) [ 31 ].…”

Section: Plant and Their Products With Anti-ulcer Activitymentioning

confidence: 99%

Antiulcerogenic and antidiarrhoeal potentials of methanolic extract of <i>Pausinystalia macroceras</i> stem-bark in rats

Cited by 7 publications

References 0 publications

Periodic Validation of High Antidiabetic Potentials of Unripe Plantain in Comparison with Glibenclamide and Fansidar

Periodic Validation of High Antidiabetic Potentials of Unripe Plantain in Comparison with Glibenclamide and Fansidar

Croton zambesicus Root Extract Exert Laxative Effect in Rats

Biotechnological aspects of plants metabolites in the treatment of ulcer: A new prospective

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