Aqueous extract of leaves of Ocimum gratissimum (OG) at doses of 0.4, 0.8 INTRODUCTlONOcimum gratissimum (Linn) family Labiaceae Is a herbaceous plant commonly found In tropical Asia especially India, where It is used for aromatic baths of fumigations in the treatment of rheumatism and paralysis. The plant is also found in West Africa. In NIgeria, it is found In the Savannah and coastal areas.In the coastal areas of Nigeria, the plant Is used In the treatment of epilepsy, (Osifo, 1992), hIgh fever (Oliver, 1980) and diarrhea (OlIver, 1980, andSofowora, 1993), whilst in the Savannah areas decoctions of the leaves are used to treat mental illness (Abdulrahman, 1992). The leaves of the plant are used as a condiment In cooking. In the southern part of Nigeria, the plant Is called "effinrin-nla" by the Yoruba speaking tribe. It is called "Ahuji" by the Igbos, while In the Northern part of Nigeria, the Hausas call it "Daidoya".In view of its many uses especially In Nigeria and the fact that traditional medicine practitioners prescribe and administer decoctions of the leaves to patients without regard to its possible adverse effects, the present investigation was undertaken to assess Its potential toxic effects on some organs (kidney, Intestine and the liver) of localization In rabbits. MATERIALS AND METHODS Collection and Identification of Plant MaterialsThe fresh leaves (800 g) of the shrub were collected from the University of Malduguri. The leaves were Identified and authenticated as Ocimum leaves, by Dr. S.S. Sanusi, a plant taxonomist in the Department of Biology, Faculty of Science, University of Maiduguri. Experimental AnimalsMale healthy rabbits bred in the Department of Pharmacology were used for the study. Their average weight was 1.2 kg. They were fed with ground leaves and tap water throughout the period of the experiment.

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The acute toxicity study of methanolic extract of Asparagus pubescens root was studied on rats.

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