Antiviral activity of anisomycin against spring viraemia of carp virus in epithelioma papulosum cyprini cells and zebrafish

Shen, Yufeng; Hu, Yang; Zhu, Bin; Wang, Gao‐Xue

doi:10.1016/j.virusres.2019.05.013

Cited by 12 publications

(4 citation statements)

References 41 publications

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“…Traumatic hippocampal neurons in the vehicle group were treated with DMSO (TET vehicle). To determine whether the effect of TET on traumatic hippocampal neurons was related to the IRE1α/JNK/CHOP signal pathway, traumatic hippocampal neurons in the Anisomycin group and the TET + Anisomycin group were treated with 10 nM Anisomycin for 24 h (Shen et al., 2019 ), and traumatic hippocampal neurons in the TET + Anisomycin group were treated with TET for 24 h.…”

Section: Methodsmentioning

confidence: 99%

Tetrandrine alleviates inflammation and neuron apoptosis in experimental traumatic brain injury by regulating the IRE1α/JNK/CHOP signal pathway

Liu

et al. 2022

Brain and Behavior

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Aim:The aim of this study was to investigate the therapeutic roles of Tetrandrine (TET) on traumatic brain injury (TBI) and the underlying mechanism. Method: Traumatic injury model of hippocampal neurons and TBI mouse model were established to evaluate the therapeutic effects. The expression of neuron-specific enolase (NSE), Caspase 3, and Caspase 12 was detected by immunofluorescence. The expression of TNF-α, NF-κB, TRAF1, ERS markers (GADD34 and p-PERK), IRE1α, CHOP, JNK, and p-JNK were evaluated by western blot. Flow cytometry was used to determine the apoptosis of neurons. Brain injury was assessed by Garcia score, cerebral water content, and Evan blue extravasation test. Hematoxylin and eosin staining was used to determine the morphological changes of hippocampal tissue. Apoptosis was assessed by TUNEL staining. Result: In traumatic injury model of hippocampal neurons, TET downregulated NSE, TNF-α, NF-κB, TRAF1, GADD34, p-PERK, IRE1α, CHOP, and p-JNK expression. TET reduced Caspase 3 and Caspase 12 cleavage. Apoptosis rate was inhibited by the introduction of TET. TET improved the Garcia neural score, decreased the cerebral water content and Evans blue extravasation, and reduced NSE, TNF-α, NF-κB, TRAF1, IRE1α, CHOP, and p-JNK expression in mice with TBI, which was significantly reversed by Anisomycin, a JNK selective activator. Conclusion: TET alleviated inflammation and neuron apoptosis in experimental TBI by regulating the IRE1α/JNK/CHOP signal pathway.

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Section: Methodsmentioning

confidence: 99%

Tetrandrine alleviates inflammation and neuron apoptosis in experimental traumatic brain injury by regulating the IRE1α/JNK/CHOP signal pathway

Liu

et al. 2022

Brain and Behavior

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“…In a study of marine actinobacteria, the potential of Streptomyces strains isolated from sponges revealed the improved growth of an ornamental fish (Xiphophorus hellerii) [56], and the administration of Streptomyces as single cell protein resulted in improved growth of the ornamental fish Southern platy fish (Xiphophorus maculatus) [36]. The potential of Streptomyces as a probiotic in aquaculture was reviewed by Tan et al [9], and to avoid overlaps, only studies published post-2016 and studies not reported in the review of Tan et al [9] are discussed in this section.…”

Section: Actinobacteria As Probioticsmentioning

confidence: 99%

Fungi and Actinobacteria: Alternative Probiotics for Sustainable Aquaculture

Ghosh,

Harikrishnan,

Mukhopadhyay

et al. 2023

Fishes

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Aquatic animals are continually being exposed to stressors under farming conditions, increasing risks to gut health that result in dysbiosis. Since restrictions are imposed on the frequent use of antibiotics in aquaculture, there is emerging demand for economically viable, environmentally safe, and sustainable alternatives for the intensive production of aquaculture species. The application of beneficial microorganisms as probiotics has been suggested and widely practiced in recent times. Bacteria and fungi are ubiquitous microorganisms that can grow in various environments where organic substrates are available. Being rich in nutrients, a fish’s aquatic environment and gastrointestinal tract confer a favorable culture milieu for the microorganisms. However, the colonization and probiotic potential of fungi and mycelial bacteria resembling fungi (actinobacteria), either in the culture environment or within the gastrointestinal tracts of fish, have received less emphasis. Apart from bacilli and lactic acid bacteria, as the most conventionally used probiotics in aquaculture, numerous studies have focused on other promising alternatives. Diverse species of yeasts and molds belonging to the kingdom ‘Fungi’ have been characterized for their prospective roles in nutrition, immunomodulation, and disease prevention in fish. Bioactive compounds such as manno-oligosaccharides and β-glucans are recognized as fungal postbiotics that improve innate immunity and disease resistance in fish. Actinobacteria are known to possess different hydrolytic enzymes and novel secondary metabolites representing their probiotic attributes. The application of these groups in water quality amelioration has also been explored. Thus, this paper presents an overview of the present status of knowledge pertaining to the effects of yeasts (Candida, Cryptococcus, Debaryomyces, Geotrichum, Leucosporidium, Pichia, Rhodosporidium, Rhodotorula, Saccharomyces, Sporidiobolus, Sporobolomyces, Trichosporon and Yarrowialipolytica), molds (Aspergillus spp.) and actinobacteria (Streptomyces) as probiotics in finfish aquaculture, as well as their occurrence within the gastrointestinal tracts of finfish. Furthermore, probiotic mechanisms, selection criteria, and future perspectives on using fungi and actinobacteria as promising probiotics are discussed.

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“…with the virus to zebrafish, significantly increasing the survival of the infected fish and reducing the viral load (Shen et al . 2019).…”

Section: Pharmacological Drugs Directed To Different Steps Of the Vir...mentioning

confidence: 99%

“…This compound showed antiviral activity against SVCV in EPC cells but also in vivo effects when it was administered i.p. with the virus to zebrafish, significantly increasing the survival of the infected fish and reducing the viral load (Shen et al 2019).…”

Section: Protein Synthesis Post-translational Modifications Virion As...mentioning

confidence: 99%

Compilation of antiviral treatments and strategies to fight fish viruses

Pereiro

Figueras

Novoa

2020

Reviews in Aquaculture

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The implementation of antiviral treatments and prophylaxis strategies in fish aquaculture needs to be established. The absence of commercial vaccines for most viral diseases affecting economically relevant fish species, and the total lack of treatments to fight these diseases once they have emerged in a fish farm remains one of the main bottlenecks in fish aquaculture production. However, although no antivirals are currently applied on farms, a great number of investigations have been conducted to assess the potential use of antiviral treatments against several fish viruses. Although most of these works were based on in vitro approaches, some included in vivo experiments to demonstrate the potential applicability of these treatments. This review summarizes the investigations conducted both in vitro and in vivo in the field of antiviral treatments against fish viruses. The highlighted works include those using piscine and non-piscine proteins with antimicrobial functions, metabolites, chemical compounds (some of which are used in medicine to treat human viruses), bioactive compounds mainly isolated from plants and bacteria, and emerging DNA-and RNA-based therapeutics. This information can be used for developing both specific and broad-spectrum antiviral strategies to be further used in the aquaculture industry, and it may even provide interesting indications for biomedical research.

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Antiviral activity of anisomycin against spring viraemia of carp virus in epithelioma papulosum cyprini cells and zebrafish

Cited by 12 publications

References 41 publications

Tetrandrine alleviates inflammation and neuron apoptosis in experimental traumatic brain injury by regulating the IRE1α/JNK/CHOP signal pathway

Tetrandrine alleviates inflammation and neuron apoptosis in experimental traumatic brain injury by regulating the IRE1α/JNK/CHOP signal pathway

Fungi and Actinobacteria: Alternative Probiotics for Sustainable Aquaculture

Compilation of antiviral treatments and strategies to fight fish viruses

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