Antiviral activity of some .beta.-diketones. 4. Benzyl diketones. In vitro activity against both RNA and DNA viruses

Diana, G. D.; Carabateas, Philip M.; Johnson, R. E.; Williams, Gordon L.; Pancic, F.; Collins, Joseph C.

doi:10.1021/jm00207a010

Cited by 49 publications

(18 citation statements)

References 12 publications

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“…[51][52][53][54] Several modifications to improve activity led to the development of arildone (WIN38020), an aryl diketone. This compound was shown to selectively inhibit poliovirus replication in vitro by preventing virion uncoating.…”

Section: B Win Compoundsmentioning

confidence: 99%

Selective inhibitors of picornavirus replication

Palma

Vliegen

Clercq

et al. 2008

Medicinal Research Reviews

232

217

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Picornaviruses cover a large family of pathogens that have a major impact on human but also on veterinary health. Although most infections in man subside mildly or asymptomatically, picornaviruses can also be responsible for severe, potentially life-threatening disease. To date, no therapy has been approved for the treatment of picornavirus infections. However, efforts to develop an antiviral that is effective in treating picornavirus-associated diseases are ongoing. In 2007, Schering-Plough, under license of ViroPharma, completed a phase II clinical trial with Pleconaril, a drug that was originally rejected by the FDA after a New Drug Application in 2001. Rupintrivir, a rhinovirus protease inhibitor developed at Pfizer, reached clinical trials but was recently halted from further development. Finally, Biota's HRV drug BTA-798 is scheduled for phase II trials in 2008. Several key steps in the picornaviral replication cycle, involving structural as well as non-structural proteins, have been identified as valuable targets for inhibition. The current review aims to highlight the most important developments during the past decades in the search for antivirals against picornaviruses.

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Section: B Win Compoundsmentioning

confidence: 99%

Selective inhibitors of picornavirus replication

Palma

Vliegen

Clercq

et al. 2008

Medicinal Research Reviews

232

217

View full text Add to dashboard Cite

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“…The search for effective antirhinovirus agents has yielded a wealth of compounds belonging to widely varying chemical classes: thiosemicarbazones (20), isoquinolines (35,43), triazinoindoles (27), guanidines (5), benzoates (30), furanyls (2), benzimidazoles (12), thiourea (18), diketones (14,16,17), flavans (3,32), flavones (25), chalcones (24), nitrobenzenes (34,41), and isoxazoles (15,31). The most recently developed antirhinovirus compounds (3,15,24,31) reach their MICs within the range of 0.001 to 0.01 ,ug/ml.…”

mentioning

confidence: 99%

Antirhinovirus activity of purine nucleoside analogs

Clercq¹,

Bernaerts²,

Bergstrom³

et al. 1986

Antimicrob Agents Chemother

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A wide variety of purine nucleoside (mainly tubercidin and adenosine) analogs, which had previously been shown to inhibit the replication of a broad spectrum of RNA viruses, were evaluated for their antirhinovirus activity in human diploid (WI-38) fibroblasts. Tubercidin, 5-(l-hydroxyethyl)tubercidin, 5-(2-buten-lyl)tubercidin, toyocamycin, and sangivamycin emerged as the most potent inhibitors. These compounds inhibited the replication of rhinovirus types 1A, 1B, and 9 at an MIC well below 1 ,ug/ml. However, these compounds proved cytotoxic for the uninfected host cells at concentrations which were only slightly higher (3-to 10-fold, on the average) than those required for inhibition of rhinovirus replication. The most selective inhibitor of rhinovirus replication was 3-deazaguanine, with a selectivity index of 50. None of the carbocyclic and acyclic analogs of adenosine tested exhibited a potent or selective antirhinovirus activity.The search for effective antirhinovirus agents has yielded a wealth of compounds belonging to widely varying chemical classes: thiosemicarbazones

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“…The functionalized 1,3-diones are potential antibacterial [1], antiviral [2], insectitial [3], antioxidant [4], antisunscreen activity [5], antitumor [6], HIV-1 Integrase (IN) inhibitors [7]. 1,3-Dione are key intermediate for the synthesis various heterocyclic compounds [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Antimicrobial Screening of 1,3-Dione with their Metal Complexes

Sampal¹,

Thakur²,

Rajbhoj³

et al. 2018

Asian J. Chem.

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General structure of enol form of 1,3-diones 1,3-Dione metal complexes are used as catalyst in reaction of olefin oxidation and epoxidation [11,12]. Europium(III)-diketonates have excellent luminescent property [13]. It is also used as chelating agent [14] and extractants for lanthanide ions [15]. 1-(5-Bromo-2-hydroxyphenyl)-3-(thiophen-2-yl)-propane-1,3-dione and its metal complexes has been synthesized. The functionalized 1,3-dione potentially acts as bidentate ligand and coordinate with the transition metal ions through β-diketo system. The synthesized diketone and their transition metal complexes have been screened for in vitro antibacterial and antifungal activity using Resazurin 96 well plate method. The transition metal complexes showed moderate to excellent antimicrobial activity against all tested bacteria and fungi which constitutes a new group of compounds that can be used as potential metal derived drugs.

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Antiviral activity of some .beta.-diketones. 4. Benzyl diketones. In vitro activity against both RNA and DNA viruses

Cited by 49 publications

References 12 publications

Selective inhibitors of picornavirus replication

Selective inhibitors of picornavirus replication

Antirhinovirus activity of purine nucleoside analogs

Synthesis, Characterization and Antimicrobial Screening of 1,3-Dione with their Metal Complexes

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