Antiviral isoindolone derivatives from an endophytic fungus Emericella sp. associated with Aegiceras corniculatum

Zhang, Guojian; Sun, Shiwei; Zhu, Tianjiao; Lin, Zhenjian; Gu, Jinyan; Li, Dehai; Gu, Qianqun

doi:10.1016/j.phytochem.2011.04.014

Cited by 121 publications

(64 citation statements)

References 38 publications

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“…(HK-ZJ) isolated from the mangrove plant Aegiceras corniculatum , have been demonstrated with the cytopathic effect inhibition assay (Zhang et al 2011). …”

Section: Antiviral Activity Of Fungal Productsmentioning

confidence: 99%

Antifungal and antiviral products of marine organisms

Cheung

Wong

Pan

et al. 2014

Appl Microbiol Biotechnol

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Marine organisms including bacteria, fungi, algae, sponges, echinoderms, mollusks, and cephalochordates produce a variety of products with antifungal activity including bacterial chitinases, lipopeptides, and lactones; fungal (−)-sclerotiorin and peptaibols, purpurides B and C, berkedrimane B and purpuride; algal gambieric acids A and B, phlorotannins; 3,5-dibromo-2-(3,5-dibromo-2-methoxyphenoxy)phenol, spongistatin 1, eurysterols A and B, nortetillapyrone, bromotyrosine alkaloids, bis-indole alkaloid, ageloxime B and (−)-ageloxime D, haliscosamine, hamigeran G, hippolachnin A from sponges; echinoderm triterpene glycosides and alkene sulfates; molluscan kahalalide F and a 1485-Da peptide with a sequence SRSELIVHQR; and cepalochordate chitotriosidase and a 5026.9-Da antifungal peptide. The antiviral compounds from marine organisms include bacterial polysaccharide and furan-2-yl acetate; fungal macrolide, purpurester A, purpurquinone B, isoindolone derivatives, alterporriol Q, tetrahydroaltersolanol C and asperterrestide A, algal diterpenes, xylogalactofucan, alginic acid, glycolipid sulfoquinovosyldiacylglycerol, sulfated polysaccharide p-KG03, meroditerpenoids, methyl ester derivative of vatomaric acid, lectins, polysaccharides, tannins, cnidarian zoanthoxanthin alkaloids, norditerpenoid and capilloquinol; crustacean antilipopolysaccharide factors, molluscan hemocyanin; echinoderm triterpenoid glycosides; tunicate didemnin B, tamandarins A and B and; tilapia hepcidin 1–5 (TH 1–5), seabream SauMx1, SauMx2, and SauMx3, and orange-spotted grouper β-defensin. Although the mechanisms of antifungal and antiviral activities of only some of the afore-mentioned compounds have been elucidated, the possibility to use those known to have distinctly different mechanisms, good bioavailability, and minimal toxicity in combination therapy remains to be investigated. It is also worthwhile to test the marine antimicrobials for possible synergism with existing drugs. The prospects of employing them in clinical practice are promising in view of the wealth of these compounds from marine organisms. The compounds may also be used in agriculture and the food industry.

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“…(HK-ZJ) isolated from the mangrove plant Aegiceras corniculatum , have been demonstrated with the cytopathic effect inhibition assay (Zhang et al 2011). …”

Section: Antiviral Activity Of Fungal Productsmentioning

confidence: 99%

Antifungal and antiviral products of marine organisms

Cheung

Wong

Pan

et al. 2014

Appl Microbiol Biotechnol

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“…Several hundred endophytic fungal extracts were evaluated on HIV-1 replication in T-lymphocytes, and out of that four extracts are non-toxic and exhibited inhibitory with the range of 75% to 99% and out of three of these extracts were fractionated and fraction DB-2 completely inhibited HIV-1 replication at concentration that was also found it is not cytotoxic [ 142 ] . In antiviral activity was reported against influenza A viral (H₁N₁) [ 143 ] for the compounds emerimidine (A, B) ,emeriphenolicins (A,D), aspernidine (A , B) austin, austinol, dehydroaustin, and acetoxy dehydroaustin for Emericella sp. (HK-ZJ) which is isolated from of plant Aegiceras corniculatum.…”

Section: Antiviral Compoundsmentioning

confidence: 99%

Endophytic Fungi as Novel Resources of natural Therapeutics

Rajamanikyam

Vadlapudi

Amanchy

et al. 2017

Braz. arch. biol. technol.

100

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“…Additionally, the endophytic Emericella sp. (HK-ZJ) isolated from another mangrove plant Aegiceras corniculatum, produces several bioactive isoindolone compounds, for which two of them showed moderate activity against influenza A virus (H 1 N 1 ) [14].…”

Section: Introductionmentioning

confidence: 99%

Antiviral and Antioxidant Potential of Fungal Endophytes of Egyptian Medicinal Plants

et al. 2018

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This study aimed to explore the antioxidant potential and antiviral activity of endophytic fungi which were isolated from healthy living tissues of medicinal plants. Endophytic strains (29 different taxa) were isolated from 18 Egyptian medicinal plants collected from Saint Katherine Protectorate, Egypt. The fungal endophytes were identified based on morphological characters. All isolates were identified as ascomycetes, except two Zygomycetes strains (Absidia corymbifera and Mucor fuscus). Isolated endophytes were cultivated on potato dextrose media. The fungal metabolites were extracted by ethyl acetate and examined for their biological activities. Among 99 total extracts, only Chaetomium globosum, which was isolated from Adiantum capillus, showed a promising DPPH (1,1-diphenyl-2-picrylhydrazyl) scavenging activity (99% at 100 µg/mL). Fifteen extracts prohibited the reproduction of HSV-2 virus. On the other hand, the reproduction of VSV-virus was inhibited by sixteen endophytic extracts. The promising anti-(HSV-2 and VSV) extract of endophytic Pleospora tarda strain; that was originally isolated from the medicinal plant Ephedra aphylla, showed viral inhibitory activity of 40.7% and 15.2%, respectively. Two compounds, for which antiviral activates could be attributed, were isolated and identified as alternariol and alternariol-(9)-methyl ether using different NMR techniques from P. tarda extract. For the first time, we report here the ability of the endophytic fungus P. tarda to produce alternariol and alternariol-(9)-methyl ether. The results indicate that the endophytic fungi from medicinal plants are promising sources of bioactive compounds.

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Antiviral isoindolone derivatives from an endophytic fungus Emericella sp. associated with Aegiceras corniculatum

Cited by 121 publications

References 38 publications

Antifungal and antiviral products of marine organisms

Antifungal and antiviral products of marine organisms

Endophytic Fungi as Novel Resources of natural Therapeutics

Antiviral and Antioxidant Potential of Fungal Endophytes of Egyptian Medicinal Plants

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