Anxiolytic and anxiogenic drug effects on male and female gerbils in the black-white box

Bradley, Belinda Fay; Bridges, Nikola Jane; Starkey, Nicola J.; Brown, Stephen L.; Lea, Robert

doi:10.1016/j.bbr.2010.08.006

Cited by 14 publications

(14 citation statements)

References 41 publications

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“…Adenosine has an inhibitory effect on the brain, and exerts robust anxiolysis in rodents (Kulkarni et al, 2007). In contrast, its non-selective antagonist caffeine acts as an anxiogenic agent, as shown in clinical (Childs et al, 2008;Lara, 2010), rodent (Bradley et al, 2010;Kulkarni et al, 2007) and zebrafish studies (Table 1).…”

Section: Other Systemsmentioning

confidence: 87%

Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models

Stewart

Cachat

et al. 2011

Progress in Neuro-Psychopharmacology and Biological Psychiatry

214

121

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Section: Other Systemsmentioning

confidence: 87%

Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models

Stewart

Cachat

et al. 2011

Progress in Neuro-Psychopharmacology and Biological Psychiatry

214

121

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“…Although the black-white box was widely used to detect anxiety by stress [42]–[45], it has recently been employed to investigate visual function [13]. An animal with light perception will escape from the white chamber to the black chamber.…”

Section: Discussionmentioning

confidence: 99%

Changes in Retinal Morphology, Electroretinogram and Visual Behavior after Transient Global Ischemia in Adult Rats

Zhao

Xiang

et al. 2013

PLoS ONE

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The retina is a light-sensitive tissue of the central nervous system that is vulnerable to ischemia. The pathological mechanism underlying retinal ischemic injury is not fully understood. The purpose of this study was to investigate structural and functional changes of different types of rat retinal neurons and visual behavior following transient global ischemia. Retinal ischemia was induced using a 4-vessel occlusion model. Compared with the normal group, the number of βIII-tubulin positive retinal ganglion cells and calretinin positive amacrine cells were reduced from 6 h to 48 h following ischemia. The number of recoverin positive cone bipolar cells transiently decreased at 6 h and 12 h after ischemia. However, the fluorescence intensity of rhodopsin positive rod cells and fluorescent peanut agglutinin positive cone cells did not change after reperfusion. An electroretinogram recording showed that the a-wave, b-wave, oscillatory potentials and the photopic negative response were completely lost during ischemia. The amplitudes of the a- and b-waves were partially recovered at 1 h after ischemia, and returned to the control level at 48 h after reperfusion. However, the amplitudes of oscillatory potentials and the photopic negative response were still reduced at 48 h following reperfusion. Visual behavior detection showed there was no significant change in the time spent in the dark chamber between the control and 48 h group, but the distance moved, mean velocity in the black and white chambers and intercompartmental crosses were reduced at 48 h after ischemia. These results indicate that transient global ischemia induces dysfunction of retinal ganglion cells and amacrine cells at molecular and ERG levels. However, transient global ischemia in a 17 minute duration does not appear to affect photoreceptors.

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“…Because anxiety in humans is more prevalent in female but the majority of published animal tests on anxiety is with male rodents (Bradley et al, 2010), we introduced mice of either sex to every group as subjects. The animal experiments had been allowed by the Bioethics Committee of Southwest University China and were periodically inspected by the Chongqing Laboratory Animal Care and Use Committee.…”

Section: Animalsmentioning

confidence: 99%

Comparative studies on anxiolytic activities and flavonoid compositions of Passiflora edulis ‘edulis’ and Passiflora edulis ‘flavicarpa’

Zhou

Yang

et al. 2011

Journal of Ethnopharmacology

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Anxiolytic and anxiogenic drug effects on male and female gerbils in the black-white box

Cited by 14 publications

References 41 publications

Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models

Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models

Changes in Retinal Morphology, Electroretinogram and Visual Behavior after Transient Global Ischemia in Adult Rats

Comparative studies on anxiolytic activities and flavonoid compositions of Passiflora edulis ‘edulis’ and Passiflora edulis ‘flavicarpa’

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