Aplicabilidade da extrapolação alométrica em protocolos terapêuticos para animais selvagens

Freitas, Gabrielle Coelho; Carregaro, Adriano Bonfim

doi:10.1590/s0103-84782013000200017

Cited by 20 publications

(18 citation statements)

References 33 publications

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“…Eremantholide C still does not have a defined dose for oral administration in humans. To analyse the solubility according to the guidelines of the BCS, by calculating the ratio dose/solubility (D/S), the allometric extrapolation of eremantholide C dose was proposed following the equations described in Eqs , and …”

Section: Methodsmentioning

confidence: 99%

In silico and in vitro prediction of gastrointestinal absorption from potential drug eremantholide C

Caldeira

Saúde-Guimarães

Dezani

et al. 2017

Journal of Pharmacy and Pharmacology

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Section: Methodsmentioning

confidence: 99%

In silico and in vitro prediction of gastrointestinal absorption from potential drug eremantholide C

Caldeira

Saúde-Guimarães

Dezani

et al. 2017

Journal of Pharmacy and Pharmacology

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“…Doses were determined by means of interspecific allometric scaling, with basal metabolic rates (TMB) calculated by multiplying a proportionality constant (K, equal to 70 for Panthera onca) by the body mass (M) of each animal in kg raised to 0.75 (TMB = K x M 0.75 ) (FREITAS; CARREGARO, 2013;PACHALY, 2006). As jaguars represent a potential risk to human safety, their handling before chemical restraint was impossible, so archived data relating to the most recent record of body mass of each animal were used and, as soon as the animal could be handled after drug injection, each animal was weighed and, when necessary, the dose was adjusted.…”

Section: Experimental Designmentioning

confidence: 99%

Chemical restraint of jaguars Panthera onca Linnaeus, 1758 with allometrically scaled doses of tiletamine, zolazepam, detomidine, and atropine

Souza

Nascimento

Hirano

et al. 2018

SCA

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Chemical restraint of large felids is necessary for the handling, transportation, clinical assessment, and induction of anesthesia. The objective of this study was to evaluate the efficacy and safety of chemical restraint using a combination of tiletamine, zolazepam, detomidine, and atropine with interspecific allometric scaling doses in captive Panthera onca. There were ten males (two melanistic ones) and five females weighing between 35 and 80 kg. The evaluation of the chemical restraint protocol was carried out during routine management of the animals for physical examination, collection of blood and bone marrow samples, dental evaluation, and other procedures. During pre-established intervals, rectal temperature, heart rate, respiratory rate, nociception of thoracic and pelvic limbs, muscle relaxation and loss of the righting reflex were monitored. Loss of the righting reflex occurred at 8 ± 1.89 minutes post-injection (MPI). Respiratory rate returned at 77.6 ± 8.18 MPI; return of consciousness occurred at 112.6 ± 12.28 MPI, and complete recovery at 153 ± 12.47 MPI. There were no statistical differences between heart and respiratory rate means and oxyhemoglobin saturation. For rectal temperature, there was a significant reduction. The protocol analyzed was efficient for the chemical restraint of jaguars, enabling the manipulation, transportation, physical examination, dental evaluation, blood and bone marrow sample collection, and other minor invasive procedures of medium duration in these animals.

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“…Animal development is related to metabolic rate, which directly influences mass, shape, size, and other body traits (von Bertalanffy, 1957). These body variations of an individual throughout their ontogeny can be measured by allometry, using an allometric coefficient "m" (Freitas & Carregaro, 2013).…”

Section: Introductionmentioning

confidence: 99%

Growth curves of meat-producing mammals by von Bertalanffy’s model

Fernandes

Pereira

et al. 2019

Pesq. agropec. bras.

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The objective of this work was to evaluate how the parameterization and the application of different allometric values affect the obtention of the most adequate fit of von Bertalanffy’s model, in the description of the growth curve of meat-producing mammals (bovine, pigs, rabbits, and sheep). Among the nonlinear models, von Bertalanffy’s has been very often applied in several areas, with different parameterizations. This model has been commonly used with an allometric value of m = 2/3; however, for mammals, it is believed that this value can be m = 3/4. The analyzed data referring to the mass of meat-producing mammals according to their age were obtained from research institutions and from the literature. The results showed that von Bertalanffy’s model, with the allometric value of m = 3/4 and the used parameterization, provided better adjustments to quality evaluators. Besides, the model softened the overestimation of parameter a, giving a direct interpretation of parameter b, with the lowest values for curvature measurements, mainly for the parametric ones, and provided more reliable adjustments. Von Bertalanffy’s model can be used in the description of the growth curves of meat-producing mammals.

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Aplicabilidade da extrapolação alométrica em protocolos terapêuticos para animais selvagens

Abstract: RESUMO Na Medicina Veterinária, a extrapolação empírica dos protocolos indicados para animais domésticos é uma prática rotineira, podendo levar a falhas por desconsiderar as

Cited by 20 publications

References 33 publications

In silico and in vitro prediction of gastrointestinal absorption from potential drug eremantholide C

In silico and in vitro prediction of gastrointestinal absorption from potential drug eremantholide C

Chemical restraint of jaguars Panthera onca Linnaeus, 1758 with allometrically scaled doses of tiletamine, zolazepam, detomidine, and atropine

Growth curves of meat-producing mammals by von Bertalanffy’s model

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