Apolipoprotein A-I stimulates AMP-activated protein kinase and improves glucose metabolism

Han, Renji; Lai, Rui-Ming; Ding, Qiurong; Wang, Zhong Min; Luo, Xiaolin; Zhang, Yixuan; Cui, Guanshen; He, Jian; Liu, W.; Chen, Yan

doi:10.1007/s00125-007-0752-7

Cited by 135 publications

(137 citation statements)

References 33 publications

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“…Student t-test was used to compare the groups with the same diet (*Po0.05 and **Po0.01). Please note that part of the data from the groups of mice fed with NC has been previously reported (Han et al, 2007). However, these data are included here for better comparison with the mice fed with HFD.…”

Section: Resultsmentioning

confidence: 99%

“…It has long been postulated that Apoa-I and HDL levels are inversely associated with the incidence of MS, which are associated with an increased risk of type II diabetes and cardiovascular diseases (Dandona et al, 2005;Eckel et al, 2005). Recently, Han et al (Han et al, 2007) showed that Apoa-I À/À mice have impaired glucose tolerance (IGT) and increased body fat because of the fact that Apoa-I activates AMP-activated protein kinase (AMPK) and thus affects the energy and glucose metabolism of the cell. Given the fact that variations in both host genetics and gut microbiota predispose animals to MS, it is compelling to investigate the relative contributions of diet-disrupted gut microbiota and host gene mutations to MS development.…”

Section: Introductionmentioning

confidence: 99%

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Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice

et al. 2009

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Both genetic variations and diet-disrupted gut microbiota can predispose animals to metabolic syndromes (MS). This study assessed the relative contributions of host genetics and diet in shaping the gut microbiota and modulating MS-relevant phenotypes in mice. Together with its wild-type (Wt) counterpart, the Apoa-I knockout mouse, which has impaired glucose tolerance (IGT) and increased body fat, was fed a high-fat diet (HFD) or normal chow (NC) diet for 25 weeks. DNA fingerprinting and bar-coded pyrosequencing of 16S rRNA genes were used to profile gut microbiota structures and to identify the key population changes relevant to MS development by Partial Least Square Discriminate Analysis. Diet changes explained 57% of the total structural variation in gut microbiota, whereas genetic mutation accounted for no more than 12%. All three groups with IGT had significantly different gut microbiota relative to healthy Wt/NC-fed animals. In all, 65 species-level phylotypes were identified as key members with differential responses to changes in diet, genotype and MS phenotype. Most notably, gut barrier-protecting Bifidobacterium spp. were nearly absent in all animals on HFD, regardless of genotype. Sulphate-reducing, endotoxin-producing bacteria of the family, Desulfovibrionaceae, were enhanced in all animals with IGT, most significantly in the Wt/HFD group, which had the highest calorie intake and the most serious MS phenotypes. Thus, diet has a dominating role in shaping gut microbiota and changes of some key populations may transform the gut microbiota of Wt animals into a pathogen-like entity relevant to development of MS, despite a complete host genome.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice

et al. 2009

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“…HDLs have antidiabetic properties. They reduce hyperglycaemia via their capacity to decrease pancreatic β-cell apoptosis (Abderrahmani et al 2007;Fryirs et al 2010;Rutti et al 2009) and to stimulate glucose disposal in skeletal muscle (Han et al 2007). They decrease dyslipidaemia via lowering adipocyte lipolysis (Van Linthout et al 2010a) and induce insulin sensitivity (Berg et al 2001) via upregulating the expression of adiponectin (Van Linthout et al 2010a), which abrogates the development of hyperinsulinaemia.…”

Section: Human Apo A-i Gene Transfer Attenuates Diabetic Cardiomyopathymentioning

confidence: 99%

Therapeutic Potential of HDL in Cardioprotection and Tissue Repair

Linthout

Frias²,

Singh

et al. 2014

High Density Lipoproteins

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“…Anti-inflammatory and antioxidative functions of HDLs have been described in addition to the innate immune function of HDLs as a defense against viral, bacterial, and parasitic infections (6). In addition, HDLs are directly involved in glucose metabolism through insulin secretion in pancreatic b-cells (13) and improvement of insulin sensitivity (14,15). Although little is known about the role of apoA-I in the development of T2D, the findings of some recent studies are in agreement with the observations described in this study.…”

Section: European Journal Of Endocrinologymentioning

confidence: 99%

Association of HDL-C and apolipoprotein A-I with the risk of type 2 diabetes in subjects with impaired fasting glucose

Hwang

Ahn

Park

et al. 2014

European Journal of Endocrinology

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Objectives: HDLs have many diverse functions. The goal of this study was to determine the association of HDL cholesterol (HDL-C) and apolipoprotein A-I (apoA-I) with the development of type 2 diabetes (T2D). In particular, this study determined the association between the ratio of HDL-C to apoA-I (HA) and incident T2D. Design and methods: A total of 27 988 subjects with impaired fasting glucose (IFG) (18 266 men and 9722 women) aged 21-91 years (mean age 40.7 years) were followed for a mean duration of 2.81 years. Results: Study subjects were divided into quartiles according to the baseline HA ratio. Age, male sex, current smoking, BMI, waist circumference, and high-sensitivity C-reactive protein decreased across the quartiles, and all metabolic profiles, including blood pressure, fasting glucose, insulin resistance as determined by homeostasis model assessment of insulin resistance, and lipid measurements such as total cholesterol, LDL cholesterol, non-HDL-C, and apoB, improved as the HA ratio increased. In addition, incident cases of T2D decreased as the HA ratio increased, independent of age, sex, BMI, current smoking, systolic blood pressure, HbA1c, fasting serum insulin, family history of diabetes, and serum triglyceride concentrations (HR (95% CI) of fourth quartile vs first quartile; 0.76 (0.67-0.86), P!0.0001). Conclusions: A higher HA ratio was associated with favorable metabolic profiles and a lower risk of T2D development in subjects with IFG.

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Apolipoprotein A-I stimulates AMP-activated protein kinase and improves glucose metabolism

Abstract: Aims/hypothesis In humans, one of the hallmarks of type 2 diabetes is a reduced plasma concentration of HDL and its major protein component, apolipoprotein A

Cited by 135 publications

References 33 publications

Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice

Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice

Therapeutic Potential of HDL in Cardioprotection and Tissue Repair

Association of HDL-C and apolipoprotein A-I with the risk of type 2 diabetes in subjects with impaired fasting glucose

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