Apoptosis in Autoimmunological Diseases, with Particular Consideration of Molecular Aspects of Psoriasis

Krawczyk, Agata; Miśkiewicz, Joanna; Strzelec, Karolina; Wcisło‐Dziadecka, Dominika; Strzałka‐Mrozik, Barbara

doi:10.12659/msm.922035

Cited by 15 publications

(9 citation statements)

References 41 publications

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“…Recently, studies confirmed that PCD is closely related to the development of psoriasis. [ 39 ] Researchers demonstrated that infliximab not only has anti-inflammatory effects in treating psoriasis, but also is associated with the induction of caspase-independent KC PCD in skin lesions. [ 40 ] Proteomic analysis confirmed the activation of apoptotic pathways in psoriasis.…”

Section: Discussionmentioning

confidence: 99%

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Identification of PANoptosis-related biomarkers and immune infiltration characteristics in psoriasis

Lu,

Zhang,

Shi

et al. 2023

Medicine

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Background: PANoptosis may play a vital role in psoriasis. We investigated the relationship between PANoptosis in psoriasis. Methods: Genes information was mainly obtained from GeneCards and the gene expression omnibus database. Genefunctions identification was based on gene ontology and Kyoto Encyclopedia of Genes and Genomes analyses. Gene set enrichment analysis was used to identify enriched signaling pathways in psoriasis. We constructed PPI networks using the search tool for the retrieval of interacting genes database and Cytoscape and explored mRNA-miRNA, mRNA-TF, and mRNA-drug interaction networks. Receiver operating characteristic curves were performed to screen potential biomarkers among these hub genes. Immune cell infiltration was analyzed using the Pearson algorithm, and the correlation between immune-cell abundance and PANoptosis-related differentially expressed gene (PDGs) was investigated. Results: We identified 10 PDGs, which were mainly involved in pyroptosis, cytokine-mediated signaling pathways, Salmonella infection and NOD-like receptor signaling pathway. The activated pathways were mostly proinflammatory and immunoregulatory pathways between immune cells. BAK1, CASP4, IL18, and IRF1 were identified as hub genes in the mRNA-miRNA network, and BAK1, IRF1, and PYCARD were hub genes in the mRNA-TF network. CASP1 was found to be the most targeted gene by drugs or molecular compounds. We found PDGs were positively associated with proinflammatory immune cell infiltration and negatively associated with anti-inflammatory or regulatory immune cells. Conclusion: We confirmed the role of PANoptosis in psoriasis for the first time and predicted hub genes and immune characteristics, which provides new ideas for further investigation of psoriasis on pathogenic mechanisms and therapeutic strategies.

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Section: Discussionmentioning

confidence: 99%

“…[ 40 ] Proteomic analysis confirmed the activation of apoptotic pathways in psoriasis. [ 39 ] In addition, ferroptosis and pyroptosis were also implicated in the pathogenesis of psoriasis. [ 11 ] PANoptosis has molecules essential for pyroptosis, apoptosis, and necroptosis, which could activate different PCD pathways.…”

Section: Discussionmentioning

confidence: 99%

Identification of PANoptosis-related biomarkers and immune infiltration characteristics in psoriasis

Lu,

Zhang,

Shi

et al. 2023

Medicine

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“…Apoptosis is a crucial physiological mechanism that effectively regulates the immune response. It plays a vital role in eliminating non-functional or autoantigen-recognizing cells [43]. In the context of Hashimoto's thyroiditis, the disease pathogenesis is characterized by the infiltration of immune system cells into the thyroid gland, leading to the death of thyrocytes.…”

Section: Importance Of Apoptosis In the Pathogenesis Of Hashimoto's T...mentioning

confidence: 99%

“…In the context of Hashimoto's thyroiditis, the disease pathogenesis is characterized by the infiltration of immune system cells into the thyroid gland, leading to the death of thyrocytes. The regulation of apoptosis involves various factors, such as TSH, anti-TPO antibodies, and inflammatory mediators such as IFN-γ and IL-2 [43]. The Fas apoptosis-inducing receptor (FAS), which possesses a death domain, plays a significant role in this process through death receptors.…”

Section: Importance Of Apoptosis In the Pathogenesis Of Hashimoto's T...mentioning

confidence: 99%

The Role of the Immune System in the Course of Hashimoto’s Thyroiditis: The Current State of Knowledge

Wrońska,

Hałasa,

Szczuko

2024

IJMS

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The process of thyroid autoimmunization develops against the background of genetic predispositions associated with class II human leukocyte antigens (HLA-DR), as well as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), protein tyrosine phosphatase non-receptor type 22 (PTPN22), and forkhead transcription box protein P3 (FOXP3). Environmental factors, such as vitamin D deficiency, Zn, Se, and Mg, as well as infections, chronic stress, pregnancy, smoking, alcohol, medications, intestinal dysbiosis, and malnutrition, also play an important role. The first stage of autoimmunization involves the accumulation of macrophages and dendritic cells, as well as plasma cells. In the second stage, the mutual interactions of individual cells in the immune system lead to a decrease in the level of CD8+ in favor of CD4+, which intensifies the synthesis of T lymphocyte derivatives, especially Th1, Th17, Tfh, and Tc, reducing the level of Treg. Consequently, the number of the anti-inflammatory cytokines IL10 and IL2 decreases, and the synthesis of the pro-inflammatory cytokines IL-2, Il-12, Il-17, IL-21, IL-22, IFN-γ, and TNF-α increases. The latter two especially trigger the pyroptosis process involving the inflammasome. Activation of the inflammasome by IL-β and IL-18 produced by macrophages is one of the mechanisms of pyroptosis in the course of Hashimoto’s thyroiditis, involving Gram-negative bacteria and NLRC4. In the next step, the apoptosis of thyroid cells is initiated by the intensification of perforin, granzyme, and proteoglycan synthesis by Tc and NK cells. The current findings raise many possibilities regarding interventions related to the inhibition of pro-inflammatory cytokines and the stimulation of anti-inflammatory cytokines produced by both T and B lymphocytes. Furthermore, since there is currently no effective method for treating thyroid autoimmunity, a summary of the review may provide answers regarding the treatment of not only Hashimoto’s thyroiditis, but also other autoimmune diseases associated with autoimmunity.

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“…Apoptosis may also constitute a relevant factor in psoriasis, since autoreactive peripheral cells from psoriatic plaques show decreased cell apoptosis rates [77]. IFI27 is a protein that leads to sensitization to IFN-mediated extrinsic apoptosis [78,79].…”

Section: Psoriasismentioning

confidence: 99%

Challenges and Opportunities for the Translation of Single-Cell RNA Sequencing Technologies to Dermatology

Ascensión

Araúzo-Bravo

Izeta

2022

Life

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Skin is a complex and heterogeneous organ at the cellular level. This complexity is beginning to be understood through the application of single-cell genomics and computational tools. A large number of datasets that shed light on how the different human skin cell types interact in homeostasis—and what ceases to work in diverse dermatological diseases—have been generated and are publicly available. However, translation of these novel aspects to the clinic is lacking. This review aims to summarize the state-of-the-art of skin biology using single-cell technologies, with a special focus on skin pathologies and the translation of mechanistic findings to the clinic. The main implications of this review are to summarize the benefits and limitations of single-cell analysis and thus help translate the emerging insights from these novel techniques to the bedside.

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Apoptosis in Autoimmunological Diseases, with Particular Consideration of Molecular Aspects of Psoriasis

Cited by 15 publications

References 41 publications

Identification of PANoptosis-related biomarkers and immune infiltration characteristics in psoriasis

Identification of PANoptosis-related biomarkers and immune infiltration characteristics in psoriasis

The Role of the Immune System in the Course of Hashimoto’s Thyroiditis: The Current State of Knowledge

Challenges and Opportunities for the Translation of Single-Cell RNA Sequencing Technologies to Dermatology

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