Appetite regulation: The central role of melatonin in Danio rerio

Piccinetti, Chiara Carla; Migliarini, Beatrice; Olivotto, Ike; G, Coletti; Amici, Adolfo; Carnevali, Oliana

doi:10.1016/j.yhbeh.2010.07.013

Cited by 83 publications

(66 citation statements)

References 68 publications

(73 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Evidence for interactions between these two hormones is scarce in birds but has been described in other vertebrates. For example, exogenous melatonin suppresses circulating ghrelin in rats (62) and inhibits ghrelin mRNA expression in the brain of zebrafish (63). The control appears to be bidirectional, because ghrelin reduces melatonin production in the pineal glands of ewes (64).…”

Section: Discussionmentioning

confidence: 99%

Ghrelin affects stopover decisions and food intake in a long-distance migrant

Goymann

Lupi

Kaiya

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Billions of birds migrate long distances to either reach breeding areas or to spend the winter at more benign places. On migration, most passerines frequently stop over to rest and replenish their fuel reserves. To date, we know little regarding how they decide that they are ready to continue their journey. What physiological signals tell a bird's brain that its fuel reserves are sufficient to resume migration? A network of hormones regulates food intake and body mass in vertebrates, including the recently discovered peptide hormone, ghrelin. Here, we show that ghrelin reflects body condition and influences migratory behavior of wild birds. We measured ghrelin levels of wild garden warblers (Sylvia borin) captured at a stopover site. Further, we manipulated blood concentrations of ghrelin to test its effects on food intake and migratory restlessness. We found that acylated ghrelin concentrations of garden warblers with larger fat scores were higher than those of birds without fat stores. Further, injections of unacylated ghrelin decreased food intake and increased migratory restlessness. These results represent experimental evidence that appetite-regulating hormones control migratory behavior. Our study lays a milestone in migration physiology because it provides the missing link between ecologically dependent factors such as condition and timing of migration. In addition, it offers insights in the regulation of the hormonal system controlling food intake and energy stores in vertebrates, whose disruption causes eating disorders and obesity.bird migration | ghrelin | migratory restlessness | food intake | stopover E very year, billions of birds migrate long distances to either reach areas offering favorable wintering conditions or breeding grounds that thrive with food during the reproductive season. For most small passerines, migration involves frequent stopovers to rest and refuel. During stopover, birds are exposed to fluctuating environmental conditions, including weather and food, which influence the duration of their stay. However, the final decision to resume migration depends on the interplay between environmental conditions, the endogenous program, and the physiological condition of an individual. Theory predicts that stopover decisions depend on amount and rate of deposition of energy stores (1, 2), and empirical findings have confirmed this hypothesis (3-12). The big and yet unanswered question is, How do birds know that they are ready to depart? That is, which physiological signals tell the brain that the fuel reserves are sufficient to resume migration? This link that connects physiological condition and brain is still unknown.Previous work has shown that fat stores are the best predictor for migratory disposition and stopover duration: Birds with larger subcutaneous (s.c.) fat stores show more migratory restlessness in captivity (8,10,13,14), stay shorter times at stopover sites (9, 11), and migrate faster (12). Because birds fuel their migratory flights primarily through fatty acid metabolism (15-...

show abstract

Section: Discussionmentioning

confidence: 99%

Ghrelin affects stopover decisions and food intake in a long-distance migrant

Goymann

Lupi

Kaiya

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…Most studies to date on fish circadian rhythms have investigated the effects of photoperiod and the time-keeping pineal hormone, melatonin, on locomotor or feeding activity, while little attention has been paid to melatonin's action on courtship behaviors such as vocalization, or more generally on underlying neural circuitry (Azpeleta et al, 2010;López-Olmeda et al, 2006;Piccinetti et al, 2010;Pinillos et al, 2001;Zhdanova et al, 2001). In songbirds, a melatonin-sensitive circadian…”

Section: Introductionmentioning

confidence: 99%

Melatonin action in a midbrain vocal-acoustic network

Feng

Bass

2013

Journal of Experimental Biology

View full text Add to dashboard Cite

Melatonin is a well-documented time-keeping hormone that can entrain an individual's physiology and behavior to the day-night cycle, though surprisingly little is known about its influence on the neural basis of social behavior, including vocalization. Male midshipman fish (Porichthys notatus) produce several call types distinguishable by duration and by daily and seasonal cycles in their production. We investigated melatonin's influence on the known nocturnal-and breeding season-dependent increase in excitability of the midshipman's vocal network (VN) that directly patterns natural calls. VN output is readily recorded from the vocal nerve as a 'fictive call'. Five days of constant light significantly increased stimulus threshold levels for calls electrically evoked from vocally active sites in the medial midbrain, supporting previous findings that light suppresses VN excitability, while 2-iodomelatonin (2-IMel; a melatonin analog) implantation decreased threshold. 2-IMel also increased fictive call duration evoked from medial sites as well as lateral midbrain sites that produced several-fold longer calls irrespective of photoregime or drug treatment. When stimulus intensity was incrementally increased, 2-IMel increased duration only at lateral sites, suggesting that melatonin action is stronger in the lateral midbrain. For animals receiving 5 days of constant darkness, known to increase VN excitability, systemic injections of either of two mammalian melatonin receptor antagonists increased threshold and decreased duration for calls evoked from medial sites. Our results demonstrate melatonin modulation of VN excitability and suggest that social contextdependent call types differing in duration may be determined by neuro-hormonal action within specific regions of a midbrain vocalacoustic network.

show abstract

“…In this regard, considering that melatonin acts as a neuroendocrine transducer, able to synchronize the physiological functions, 5 an increasing number of studies have focused on photoperiod and melatonin influence on food intake regulation in both mammals and fish. [6][7][8][9] Melatonin is produced rhythmically with high levels at night and low levels during the day in both diurnal and nocturnal species, 4 and its effect on food intake is often different (appetite stimulation, inhibition, or no effect) depending on the habits of each species. [10][11][12][13] In particular, our recent study on the central regulation of appetite in zebrafish demonstrated that melatonin is able to modulate not only food intake but also the most central appetite signals.…”

Section: Introductionmentioning

confidence: 99%

“…[10][11][12][13] In particular, our recent study on the central regulation of appetite in zebrafish demonstrated that melatonin is able to modulate not only food intake but also the most central appetite signals. 9 It has been demonstrated that melatonin, the hormonal mediator of biological rhythms, also acts at the peripheral level affecting adiposity, growth, and body weight, in both mammals and fish, although such effects are highly variable. 7,14 In fish, a contrasting action of melatonin on growth has been observed: a significant weight increase was found in Atlantic salmon implanted with melatonin, 15 while in both trout and goldfish, implants or injections reduced body weight and growth rate.…”

Section: Introductionmentioning

confidence: 99%

“…Considering the limited and contrasting data available on the control of energy balance by melatonin and on the bases of previous results obtained in our laboratory on the central control of melatonin in zebrafish appetite, 9 in this study we aimed to elucidate the melatonin effects on peripheral organs involved in appetite, growth, and lipid metabolism in Danio rerio. Major peripheral signals involved in energy homeostasis control and growth such as LPT, MC4R, PPARs, SREBP, and IGF-1 were analyzed with a concomitantly evaluation of metabolic resources distribution.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Melatonin and Peripheral Circuitries: Insights on Appetite and Metabolism in Danio Rerio

et al. 2013

Self Cite

View full text Add to dashboard Cite

Melatonin is a neuroendocrine transducer of circadian/circannual rhythms able to synchronize organism's physiological activity. On the basis of our recent findings on appetite regulation by melatonin in the zebrafish brain, the aim of this study was to evaluate melatonin's role in peripheral circuitries regulating food intake, growth, and lipid metabolism. For this purpose, the effect of two melatonin doses (100 nM and 1 lM) administered for 10 days, via water, to adult zebrafish was evaluated at both physiological and molecular levels. The major signals controlling energy homeostasis were analyzed together. Additionally, the effect of melatonin doses on muscle metabolic resources was evaluated. The results obtained indicate that melatonin reduces food intake by stimulating molecules involved in appetite inhibition, such as leptin (LPT), in the liver and intestine and MC4R, a melanocortin system receptor, in the liver. Moreover, melatonin decreases hepatic insulin-like growth factor-I (IGF-I) gene expression, involved in growth process and other signals involved in lipid metabolism such as proliferator-activated receptors (PPARa, b, and c) and sterol regulatory element-binding protein (SREBP). These results were correlated with lower levels of lipids in the muscles as evidenced by the macromolecular pools analyses. The findings obtained in this study could be of great interest for a better understanding of the molecular mechanisms as the basis of food intake control and, in turn, can be a useful tool for medical and aquaculture applications.

show abstract

Appetite regulation: The central role of melatonin in Danio rerio

Cited by 83 publications

References 68 publications

Ghrelin affects stopover decisions and food intake in a long-distance migrant

Ghrelin affects stopover decisions and food intake in a long-distance migrant

Melatonin action in a midbrain vocal-acoustic network

Melatonin and Peripheral Circuitries: Insights on Appetite and Metabolism in Danio Rerio

Contact Info

Product

Resources

About