Application of a widely-used tropical anti-worm agent, mebendazole, in modern oncology

Popović, Dušica J.; Poša, Mihalj; Popović, K; Kolarovic, Jovanka; Popović, Jovan; Banović, Pavle

doi:10.4314/tjpr.v16i10.32

Cited by 6 publications

(2 citation statements)

References 34 publications

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“…The benzimidazoles are largely applied in agriculture, veterinary and medicine as antifungal, anticancer, antiparasitic, anti-hypertensive, antiviral and anti-inflammatory drugs [22][23][24]. The structures of some famous benzimidazole-based drugs (1-10) as well as their pharmaceutical profiles are shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of fish scale derived hydroxyapatite silica propyl bis aminoethoxy ethane cuprous complex (HASPBAEECC) as a novel hybrid nano-catalyst for highly efficient synthesis of new benzimidazole-1,2,3-triazole hybrid analogues as antifungal agents

et al. 2021

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The preparation, characterization and application of hydroxyapatite silica propyl bis aminoethoxy ethane cuprous complex (HASPBAEECC) as a novel hybrid nano-catalyst for synthesis of new benzimidazole-1,2,3-triazole hybrid analogues as promising antifungal agents have been described. HASPBAEECC is fully characterized by different microscopic, spectroscopic and physical techniques, including scanning electron microscopy (SEM), transmission, X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDS), thermogravimetric analysis (TGA) and FT-IR. The ʻClick̕ Huisgen cycloaddition reaction of N-propargyl benzimidazole with diverse azidoalkyls in a THF-water media at ambient temperature provides the products in good-to-excellent yields using HASPBAEECC. HASPBAEECC is proved to be a stable, low cost, reusable and environmentally benign nanohybrid catalyst. The target compounds were screened against some pathogenic fungal comprising Candida albicans, Candida krusei, Candida parapsilosis, Aspergillus fumigatus and Aspergillus flavus in which it was determined that compounds 11f and 11 h have displayed promising antifungal activity similar to fluconazole as a reference drug.

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Section: Introductionmentioning

confidence: 99%

Synthesis of fish scale derived hydroxyapatite silica propyl bis aminoethoxy ethane cuprous complex (HASPBAEECC) as a novel hybrid nano-catalyst for highly efficient synthesis of new benzimidazole-1,2,3-triazole hybrid analogues as antifungal agents

et al. 2021

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“…13,14 Two BCars, albendazole (ALB) and mebendazole (3), developed nearly 50 years ago were recently reintroduced as potential oral therapeutics for glioblastoma. [15][16][17] However, systemic bioavailability and brain uptake of these drugs after oral administration are low. 18 Maximum plasma concentrations of compound 3 are *100 nM.…”

Section: Introductionmentioning

confidence: 99%

Biological Evaluation of a Potential Anticancer Agent MethylN-[5-(3′-Iodobenzoyl)-1H-Benzimidazol-2-yl]Carbamate

Kortylewicz

Coulter

Baranowska‐Kortylewicz

2020

Cancer Biotherapy and Radiopharmaceuticals

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Background: Resistance of cancer to chemo-and radiotherapy remains a major clinical problem. This study contributes to the ongoing search for agents that can bypass this resistance by developing a novel antimitotic theranostic. Materials and Methods: Methyl N-[5-(3¢-iodobenzoyl)-1H-benzimidazol-2-yl]carbamates 1 and 2 were synthesized from a common precursor 3 or its 3¢-stannylated derivative. The cytotoxicity of compound 1 was evaluated in several neuroblastoma and glioblastoma cell lines and in the NCI 60-cell assay. Biodistribution was conducted in mice after oral administration of compound 2 to determine tissue and brain uptake. Result: Lethal concentrations (LC 50 s) of compound 1 in neuroblastoma and glioblastoma are >15 • lower compared with compound 3, a drug currently tested in clinical studies in pediatric and adult brain tumors. Growth inhibition concentrations (GI 50 ) are in the nanomolar range in 60 cancer cell lines. When compound 1 is combined with a 4-Gy dose of radiation, <0.5% of cells retain their reproductive integrity. Increased hydrophobicity of new agents greatly enhances their brain uptake after oral administration. Conclusions: Compound 1 is potently cytotoxic in a wide range of human cancer cell lines. Its structure allows incorporation of imaging and therapeutic radionuclides. It is therefore expected that compound 1 can be developed into a novel theranostic modality across a wide range of malignancies.

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Co-treatment with nitroglycerin and metformin exhibits physicochemically and pathohistologically detectable anticancer effects on fibrosarcoma in hamsters

Popović

Miljković

et al. 2020

Biomedicine & Pharmacotherapy

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Application of a widely-used tropical anti-worm agent, mebendazole, in modern oncology

Cited by 6 publications

References 34 publications

Synthesis of fish scale derived hydroxyapatite silica propyl bis aminoethoxy ethane cuprous complex (HASPBAEECC) as a novel hybrid nano-catalyst for highly efficient synthesis of new benzimidazole-1,2,3-triazole hybrid analogues as antifungal agents

Synthesis of fish scale derived hydroxyapatite silica propyl bis aminoethoxy ethane cuprous complex (HASPBAEECC) as a novel hybrid nano-catalyst for highly efficient synthesis of new benzimidazole-1,2,3-triazole hybrid analogues as antifungal agents

Biological Evaluation of a Potential Anticancer Agent MethylN-[5-(3′-Iodobenzoyl)-1H-Benzimidazol-2-yl]Carbamate

Co-treatment with nitroglycerin and metformin exhibits physicochemically and pathohistologically detectable anticancer effects on fibrosarcoma in hamsters

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