Application of a xanthene dye, eosin Y, as spectroscopic probe in chemical and pharmaceutical analysis; a review

Derayea, Sayed M.; Nagy, Dalia M.

doi:10.1515/revac-2017-0020

Cited by 49 publications

(26 citation statements)

References 80 publications

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“…EY is a carboxylic dye that is used as an ion-pairing reagent for the spectroscopic determination of cationic drugs in an acidic medium by forming ion-pair complexes [11][12][13][14][15]. In the spectrophotometric method, the ABS of the developed complex was measured at 550 nm (figure 2).…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, the experimental conditions were optimized using the design of experiments (DOEs). Some amino compounds can be determined using an acidic dye called EY as an ion-pairing agent (figure 1b) via binary complex formation [11][12][13][14][15]. DOE is a powerful data collection and analysis tool that can be used under various experimental conditions [16].…”

Section: Introductionmentioning

confidence: 99%

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Factorial design-assisted spectroscopic determination of oxybutynin hydrochloride

et al. 2021

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In this study, we have developed two facile spectroscopic methods for quantifying oxybutynin (OBT) hydrochloride in its pure form and tablets using design of experiments (DOEs). The spectroscopic methods depended on the ion-pair complex formation between the tertiary amino group in the drug and eosin in 0.2 M acetate buffer of pH 4. Method I involves spectrophotometric measurement of the absorbance of the developed complex at 550 nm and showed linearity through 1.0–10.0 µg ml −1 . Method II involves spectrofluorometric measurement of the quenching influence of OBT on the native fluorescence of eosin (λ excitation/λ emission of 304/548 nm) and showed linearity through 1.0–6.0 µg ml −1 . Critical parameters were identified through preliminary trials and optimized using the DOE. Additionally, the quenching mechanism was investigated and the pathway of the reaction was postulated. The fluorescence quenching constant and thermodynamic parameters were explored using the Stern–Volmer plot and Van't Hoff graph, respectively. Assessments conducted via analytical ecoscale revealed the ‘excellent-greenness’ of the methodology. The two methods have the potentials of being green and fast compared with other reported methods.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Factorial design-assisted spectroscopic determination of oxybutynin hydrochloride

et al. 2021

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“…These dyes have long been used for fluorescence studies due to their high sensitivity to changes on their microenvironment. For instance, eosin Y, bound to ligands, has been frequently used to register Co, Ag, Zn, Cd, and Pb ions via making triple complexes with these metals and ligands [53]. Moreover, eosin is widely employed in electrochemistry to create electrodes sensitive to Cd [54].…”

Section: Methodsmentioning

confidence: 99%

Toward a Selective Analysis of Heavy Metal Salts in Aqueous Media with a Fluorescent Probe Array

Melnikov

Bykov

Varezhnikov

et al. 2022

Sensors

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Detection of heavy meals in aqueous media challenges worldwide research in developing particularly fast and affordable methods. Fluorescent sensors look to be an appropriate instrument for such a task, as recently they have been found to have made large progress in the detection of chemical analytes, primarily in the environment, along with biological fluids, which still suffer from not enough selectivity. In this work, we propose a new fluorescent method to selectively recognize heavy metals in an aqueous solution via employing an array of several fluorescent probes: acridine yellow, eosin, and methylene blue, which were taken as examples, being sensitive to a microsurrounding of the probe molecules. The exemplary sensor array generated six channels of spectral information through the use of various combinations of excitation and detection wavelengths. Following the known multisensor approach, we applied a linear discriminant analysis to selectively distinguish the vector signals from the sensor array from salts of heavy metals—Cu, Pb, Zn, Cd, and Cz—at the concentration ranges of 2.41 × 10−6–1.07 × 10−5 M, 2.8 × 10−5–5.87 × 10−4 M, 1.46 × 10−6–6.46 × 10−6 M, 1.17 × 10−8–5.2 × 10−8 M, and 2.11 × 10−6–9.33 × 10−6 M, respectively. The suggested approach was found to be promising due to it employing only one cuvette containing the test solution, simplifying a sample preparation when compared to preparing a variety of solutions in tests with single fluorescence probes.

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“…Xanthene-based fluorescent dyes largely containing fluorescein and rhodamine have attracted continuous attention from researchers because of their good photophysical properties such as high absorption coefficient, high photostability, and high fluorescence quantum yield [1][2][3][4][5][6][7][8]. However, absorption and emission wavelengths of many xanthene derivatives are in the ultraviolet-visible light range below 600 nm, which makes them unsuitable for bioimaging in living systems [9].…”

Section: Introductionmentioning

confidence: 99%

Rhodium (II)-Catalyzed Synthesis of Tetracyclic 3,4-Fused Indoles and Dihydroindoles

et al. 2020

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Application of a xanthene dye, eosin Y, as spectroscopic probe in chemical and pharmaceutical analysis; a review

Cited by 49 publications

References 80 publications

Factorial design-assisted spectroscopic determination of oxybutynin hydrochloride

Factorial design-assisted spectroscopic determination of oxybutynin hydrochloride

Toward a Selective Analysis of Heavy Metal Salts in Aqueous Media with a Fluorescent Probe Array

Rhodium (II)-Catalyzed Synthesis of Tetracyclic 3,4-Fused Indoles and Dihydroindoles

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