The search for renewable, affordable, sustainable, and ecologically benign fuels to substitute fossil-based diesel fuels has led to increased traction in the search for biodiesel production and utilization in recent times. Biodiesel, a form of liquid biofuel, has been found to alleviate environmental degradation, enhance engine performance, and reduce emissions of toxic gases in transportation and other internal combustion engines. However, biodiesel production processes have been dogged with various challenges and complexities which have limited its expected progression. The introduction of data-based technologies is one of the remedies aimed at deescalating the challenges associated with biodiesel synthesis. In this study, the application of machine learning (ML) –based technologies including artificial neural network (ANN), response surface methodology (RSM), adaptive network-based fuzzy inference system (ANFIS), etc. As tools for the prediction, modeling, and optimization of the biodiesel production process was interrogated based on the outcomes of previous studies in the research domain. Specifically, we review the influence of input variables like alcohol: oil molar ratio, catalyst concentration, reaction temperature, residence time, and agitation speed on the biodiesel yield (output variable). The outcome of this investigation shows that the usage of ANN, RSM, ANFIS, and other machine learning technologies raised biodiesel yield to between 84% and 98% while the statistical verification shows that the Pearson correlation coefficient and coefficient of determination are close to 1. Going forward, more targeted and collaborative research is needed to escalate the use of innovative technologies for the entire biodiesel value chain to enhance production efficiency, ensure economic feasibility, and promote sustainability.