Application of Box-Behnken design with response surface methodology for modeling and optimizing ultrasonic oxidation of arsenite with H2O2

Qiu, Pengpeng; Cui, Mingcan; Kang, Kyounglim; Park, Beomguk; Son, Yong-Gyu; Khim, Eunkyung; Jang, Min; Khim, Jong Seong

doi:10.2478/s11532-013-0360-y

Cited by 85 publications

(54 citation statements)

References 28 publications

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“…However, the amount of TEA does not affect the SA as the P value is more than 0.05. The coefficient correlation (R 2 ) is a measurement of the degree of fit, and the model that shows the closest value to 1 of R 2 indicates a great fit [20]. The response SA exhibited an R 2 value of 0.8054 and an adjusted R 2 value of 0.7605 at 95% confidence level.…”

Section: Resultsmentioning

confidence: 99%

Optimization of Synthesis Parameters of Mesoporous Silica Nanoparticles Based on Ionic Liquid by Experimental Design and Its Application as a Drug Delivery Agent

Isa

Ahmad

Rahman

2019

Journal of Nanomaterials

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Optimization is a process utilized to discover the best condition to generate the best possible outcome. One of the common optimization method used in the field of chemistry is response surface methodology (RSM). This method consists of mathematical and statistical techniques which relate the responses with the variables of interest. There are many experimental designs in RSM, and one of the most common one is the Box-Behnken design (BBD). In this work, BBD was employed to analyze the main effects and interactions of the reaction temperature, amount of template, and amount of triethanolamine (TEA) on the two responses which are the surface area (SA) and particle size (PS) of ionic liquid templated mesoporous silica nanoparticles (MSNs). It was found that the SA and PS were fitted with linear and quadratic models, respectively. MSNs with the highest surface area (999.051 m2 g-1) was chosen for the application of drug delivery; thus, drug loading and drug release experiments were conducted. From these studies, it was found that 37% of drug (quercetin) was successfully encapsulated in MSN and, in 48 hours, 32% of the drug was released.

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Section: Resultsmentioning

confidence: 99%

Optimization of Synthesis Parameters of Mesoporous Silica Nanoparticles Based on Ionic Liquid by Experimental Design and Its Application as a Drug Delivery Agent

Isa

Ahmad

Rahman

2019

Journal of Nanomaterials

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“…Menurut (Qiu et al, 2014), pada proses penggabungan ultrasonik dengan hidrogen peroksida (US/ H 2 O 2 ) akan menghasilkan suatu radikal OH* disaat terjadi pirolisis H 2 O 2 melalui fenomena kavitasi. Kavitasi akan terjadi di saat iradiasi ultrasonik dalam media cairan.…”

Section: Pendahuluanunclassified

“…Alat yang dibutuhkan adalah pipet volume, beaker glass, gelas ukur, labu ukur, pH meter, termometer, saringan dengan ukuran pori 0,45 μm, elenmeyer, corong, timbangan digital, pengaduk magnetik, cawan aluminium, cawan porselen/cawan Gooch, penjepit, kaca arloji, pompa vacuum, reaktor COD, biuret, oven untuk pengoperasian pada suhu 103ºC sampai dengan 105ºC, desikator yang berisi silika gel, alat ultrasonik dengan frekuensi 47 kHz. (Manohar et al, 2013), (Qiu et al, 2014), dan (Philippi et al, 2016) menyebutkan bahwa nilai R 2 dapat menunjukkan persamaan model respon yang dievaluasi pada suatu eksperimen. Nilai R 2 yang diperoleh dari suatu model yang baik adalah lebih besar dari 0,8 karena pada nilai tersebut reaksi yang terjadi dapat dijelaskan dengan baik.…”

Section: Metodologi Penelitianunclassified

“…Pada model quadratik, kemampuan variabel bebas dalam menjelaskan varian dari variabel terikat adalah sebesar 94,99% (Agarry SE et al, 2012). Selain nilai R 2 , nilai Adj-R 2 juga merupakan suatu faktor penting untuk melihat kesesuaian regresi model (Qiu et al, 2014 (Liu et al, 2013). Jika nilai Prob > F lebih kecil dari 0,05, maka mengindikasikan model tersebut signifikan, dan untuk nilai Prob > F lebih dari 0,05 mengindikasikan model tersebut tidak signifikan (Qiu et al, 2014 Reaksi oksidasi yang cepat akan meningkatkan persen penurunan COD dari LCRS.…”

Section: Disain Percobaanunclassified

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Pengolahan Limbah Cair Rumah Sakit secara Sonochemical

Kusuma¹,

Darmadi²,

Adisalamun³

2017

JLI Padang

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Hospital as a service provider has an important role in human life, especially for people who are experiencing physical and mental disorders. Various types of diseases and therapies performed in hospitals has made it as one of the producers of hazardous and infectious waste that requires special handling and processing so as not to pollute the water, soil, and air environment. Hospital wastewater treatment was conducted to determine the ability of sonochemical method to reduce level of Chemical Oxygen Demand (COD) and determine the optimum conditions of the parameters used by the design of Response Surface Methodology Box-Behnken. The parameters that affected this process was the concentration of hydrogen peroxide (H 2 O 2), pH, and reaction time. The Waste used was taken from the waste water treatment plant in Zainoel Abidin General Hospital in Banda Aceh with COD value 260.65 ppm. The optimum conditions of this treatment process occured at pH 2, H 2 O 2 concentration 500 ppm, and reaction time 119.98 minutes with reduction of COD was 81.88%.

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“…The dissolution of the iron increased at a high current, resulting in a larger amount of precipitate; moreover, the bubble rate increased and its size decreased with the increasing current. Then, TSS and TDS were reduced in a high time and voltage because the process did not reduce them anymore (Qiu et al, 2014). The removal of TSS was low during the first 15 minutes, and, after 37 minutes, it decreased because of the effect of NaCl on the coagulant stabilization.…”

mentioning

confidence: 99%

The Optimization of the Electrocoagulation of Palm Oil Mill Effluent with a Box-Behnken Design

Lubis¹,

Fujianti²,

Zahara³

et al. 2019

IJTech

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Unmanageable industrial wastewater will have an impact on the environment. One of the alternative wastewater treatment technologies is electrocoagulation. This study investigates the effects of voltage, time, and NaCl concentrations on wastewater through electrocoagulationspecifically, how they affect the total suspended solid (TSS), the total dissolved solid (TDS), and the chemical oxygen demand (COD) reduction of palm oil mill effluent (POME)-with response surface methodology. An iron electrode was used with a time variation of 15, 30, and 45 minutes; a voltage variation of 10, 15, and 20 volts; and NaCl concentrations of 0.0, 0.5, and 1.0 M. A Box-Behnken design in the response surface method formed the model and optimized the electrocoagulation. Optimization of COD, TSS, and TDS reductions with the response surface methodology was accomplished at 93.12%, 97.70%, and 41.06% respectively, in 37 minutes with 20 volts, and no NaCl concentration. The analysis of variance (ANOVA) showed that the quadratic model, with the R 2 coefficients of COD, TSS, and TDS at 0.99, 0.97, and 0.92, respectively, and the adjusted-R 2 values at 0.97, 0.94, and 0.83, respectively. Conformity testing for the optimum conditions proved the model's validity, yielding COD, TSS, and TDS reduction efficiency at 93.27%, 97.64%, and 40.78%, respectively. The results of this study were useful for predicting and controlling the COD, TSS, and TDS removal efficiencies in different conditions, and they will provide information on wastewater disposal's impact on the environment without going through the first processing stage. Therefore, electrocoagulation is a more economical POME processing technique.

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Application of Box-Behnken design with response surface methodology for modeling and optimizing ultrasonic oxidation of arsenite with H2O2

Cited by 85 publications

References 28 publications

Optimization of Synthesis Parameters of Mesoporous Silica Nanoparticles Based on Ionic Liquid by Experimental Design and Its Application as a Drug Delivery Agent

Optimization of Synthesis Parameters of Mesoporous Silica Nanoparticles Based on Ionic Liquid by Experimental Design and Its Application as a Drug Delivery Agent

Pengolahan Limbah Cair Rumah Sakit secara Sonochemical

The Optimization of the Electrocoagulation of Palm Oil Mill Effluent with a Box-Behnken Design

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