Application of concentrated growth factors in reconstruction of bone defects after removal of large jaw cysts: The two cases report

Mirković, Siniga; Djurdjević-Mirković, Tatjana; Pugkar, Tatjana

doi:10.2298/vsp1504368m

Cited by 36 publications

(28 citation statements)

References 7 publications

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“…CGFs are applicable alone or when mixed with bone graft material. Application of piezoelectric, CGF sticky bone and membrane is therefore one of the most current methods for reconstruction of bone defects in the maxillary sinus area [4,8,19]. Additional use of PBM further enhances the prospect of clinical success.…”

Section: Discussionmentioning

confidence: 99%

Multidisciplinary approach to maximize angiogenesis and wound healing using piezoelectric surgery, concentrated growth factors and photobiomodulation for dental implant placement surgery involving lateral wall sinus lift: two case reports.

et al. 2020

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Background : The combined application of surgical and therapeutic modalities to improve the rate and or degree of healing and tissue regeneration is gaining in popularity. Aim : This study describes two case reports using piezoelectric surgery (PES), concentrated growth factors (CGF) and photobiomodulation (PBM) as a means of enhancing angiogenesis and tissue regeneration following dental implant sinus lift procedures. Materials and Methods : Sinus lateral windows were created using PES and the sinus membrane raised to make a new partition. Dental implants were inserted concurrently and packed with autologous fibrin rich CGF. Wound sites underwent PBM treatment using a multiwave locked system laser. The efficacy of the multidisciplinary approach was assessed by radiographic and clinical evaluation one, three, six, ten, and twelve-months post-surgery. Results : Postoperative revival was ordinary with no noteworthy postoperative complications. Wound closure and angiogenesis occurred shortly after day one. New bone formation in all augmented maxillary sinuses was detected alongside the implants on plain radiographs and on conebeam computed tomograms. The patients were highly satisfied (>80%) with the treatment regime and the success rate of the implants was 100% after a usual 10 months loading period. Conclusion : PBM, PES, and CGF promoted angiogenesis and wound healing following lateral wall sinus lift by increasing wound approximation and decreasing bleeding and swelling. Patients recorded less postoperative pain, speech impairment, analgesic use and trismus.

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Section: Discussionmentioning

confidence: 99%

Multidisciplinary approach to maximize angiogenesis and wound healing using piezoelectric surgery, concentrated growth factors and photobiomodulation for dental implant placement surgery involving lateral wall sinus lift: two case reports.

et al. 2020

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“…Due to these facts the regenerative potential of CGF increases and promotes tissue healing. It is important to use methods which stabilize the clot and thereby decrease the risk of wound healing impairment [8]. As is commonly known, wound healing is a combined process, supported by growth factors released from blood platelets.…”

confidence: 99%

The influence of application of concentrated growth factors on post-operative complications – in vivo split-mouth study

Gnatek¹,

Janas-Naze²

2019

jos

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Introduction: New methods of tissue regeneration revealed a new preparation called CGF -concentrated growth factors. CGF belong to the group of platelet-reach plasma preparations, obtained by blood collecting and its centrifugation. Objectives: The aim was to evaluate the influence of CGF application in post-operative soft tissue and bone defects on post-operative complications and wound healing. Material and methods: The research was conducted in twenty patients with a symmetric single tooth (single or multi-root) qualified for extraction. On one side of the dental arch, the post-operative region was filled with CGF material, while on the other side it was left to heal by standard primary intention. Pain, swelling, alveolar osteitis, use of antibiotics, analgesics intake and wound healing were evaluated in the post-operative period. Results: The risk associated with the occurrence of pain classified higher on the Numeric Rating Scale (NRS) than the given category increased 3.4 times if the alveolus was not filled with CGF (p < 0.05). The risk of swelling on a given day after surgery dropped about 44 times when CGF was applied (p < 0.05, p < 0.01, p < 0.05). In cases where the alveolus was filled with CGF, the use of the membrane reduced the risk of edema by 7.5 times in the seven-day period after surgery. Filling the alveolus with CGF resulted in a 5.7-fold decrease in the risk of having to use antibiotics after tooth extraction (p < 0.01). The possibility for complete healing of the alveolus up to the seventh day after surgery was about 5.5 times lower when the alveolus was not filled with CGF (p < 0.05). Conclusion:The filling of a post-operative defect with CGF reduces the frequency and intensity of post-operative pain, swelling, antibiotic therapy intake and the occurrence of facial edema, which improves the quality of life in the post-operative period.

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“…In our everyday clinical practice, we face a relatively large number of patients presenting with a substantial deficit of the residual alveolar ridge due to the loss of single or several teeth who require implant-prosthetic treatment. In such situations, the augmentation of lost bony structures is indicated in order to provide optimal conditions for dental implant placement and subsequent prosthetic rehabilitation [1]. Nowadays, a whole range of modern surgical procedures and a variety of dental materials for reconstruction of bony defects of the upper and lower jaws and for the augmentation of lost structu-Summary Introduction.…”

Section: Introductionmentioning

confidence: 99%

“…The application of fibrin rich blocks with concentrated growth factors (CGF) is one of the latest approaches to guided bone regeneration (GBR). Fibrin rich blocks are applicable either alone or mixed/ combined with any of synthetic bone grafts [1,2].…”

Section: Introductionmentioning

confidence: 99%

Application of fibrin rich blocks with concentrated growth factors in pre-implant augmentation procedures

Tadić

Puškar²,

Petronijevic³

2014

Med pregl

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The loss of a single tooth or several teeth sometimes entails the augmentation of lost bony structures in order to provide optimal conditions for dental implant placement and subsequent prosthetic rehabilitation. A range of contemporary surgical procedures and a variety of dental materials for reconstruction of bony defects of the upper and lower jaws are available nowadays. The method described in this paper, i.e. the application of concentrated growth factors is one of the latest approaches which poses no risk of transmissible and allergic diseases and is at the same time cost effective.

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Application of concentrated growth factors in reconstruction of bone defects after removal of large jaw cysts: The two cases report

Abstract: Application of fibrin rich blocks containing CGF is one of the possible methods for reconstruction of bone defects. CGF can be applied alone or mixed with a bone graft. The method is relatively simple, without risk of transmissible and allergic diseases and economically feasible.

Cited by 36 publications

References 7 publications

Multidisciplinary approach to maximize angiogenesis and wound healing using piezoelectric surgery, concentrated growth factors and photobiomodulation for dental implant placement surgery involving lateral wall sinus lift: two case reports.

Multidisciplinary approach to maximize angiogenesis and wound healing using piezoelectric surgery, concentrated growth factors and photobiomodulation for dental implant placement surgery involving lateral wall sinus lift: two case reports.

The influence of application of concentrated growth factors on post-operative complications – in vivo split-mouth study

Application of fibrin rich blocks with concentrated growth factors in pre-implant augmentation procedures

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