Application of Electrospun Nanofiber as Drug Delivery Systems: A Review

Vojoudi, Elham; Babaloo, Hamideh

doi:10.2174/2211738510666220928161957

Cited by 11 publications

(5 citation statements)

References 132 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antibiotics constitute the predominant antimicrobial active ingredients utilized in the formulation of electrostatic spinning carrier systems. , Aminoglycosides, β-lactams, glycopeptides, quinolones, sulfonamides, and tetracyclines are currently utilized in the formulation of wound dressings. , Furthermore, iron oxide, silver nanoparticles, and zinc oxide (ZnO) possess broad-spectrum antimicrobial properties due to the presence of active antimicrobial ingredients . ZnO nanoparticles, ranging in diameter from 1 to 100 nm, are considered to be fine inorganic materials with diverse functionalities.…”

Section: Applications Of Electrospun Nanofiber Scaffolds In Stementioning

confidence: 99%

Electrospun Nanofiber Scaffold for Skin Tissue Engineering: A Review

Wu,

Yu,

Shao

et al. 2024

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

Skin tissue engineering (STE) is widely regarded as an effective approach for skin regeneration. Several synthetic biomaterials utilized for STE have demonstrated favorable fibrillar characteristics, facilitating the regeneration of skin tissue at the site of injury, yet they have exhibited a lack of in situ degradation. Various types of skin regenerative materials, such as hydrogels, nanofiber scaffolds, and 3D-printing composite scaffolds, have recently emerged for use in STE. Electrospun nanofiber scaffolds possess distinct advantages, such as their wide availability, similarity to natural structures, and notable tissue regenerative capabilities, which have garnered the attention of researchers. Hence, electrospun nanofiber scaffolds may serve as innovative biological materials possessing the necessary characteristics and potential for use in tissue engineering. Recent research has demonstrated the potential of electrospun nanofiber scaffolds to facilitate regeneration of skin tissues. Nevertheless, there is a need to enhance the rapid degradation and limited mechanical properties of electrospun nanofiber scaffolds in order to strengthen their effectiveness in soft tissue engineering applications in clinical settings. This Review centers on advanced research into electrospun nanofiber scaffolds, encompassing preparation methods, materials, fundamental research, and preclinical applications in the field of science, technology, and engineering. The existing challenges and prospects of electrospun nanofiber scaffolds in STE are also addressed.

show abstract

Section: Applications Of Electrospun Nanofiber Scaffolds In Stementioning

confidence: 99%

Electrospun Nanofiber Scaffold for Skin Tissue Engineering: A Review

Wu,

Yu,

Shao

et al. 2024

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

show abstract

“…Due to the previous advantages, nanofibers have many applications such as drug delivery systems [30], industrial building design [31], biomedicine [32,33], 4D printing industry [34], textile industry [35,36], and wastewater remediation [37]. Nanofibers could be produced by electrospinning and non-electrospinning techniques (Figure 2).…”

Section: Nanofibers In Water Energy and Foodmentioning

confidence: 99%

“…The therapeutic application of nanofiber composites is extensive, they can be used orally, transdermally, or intravenously in different types of therapies (Figure 12). These applications may involve the delivery of drugs [30], bionanocomposites [154], and genes [155], as well as different applications in the field of tissue engineering for many human organs including bone [156], tendon [157], skin [158], cartilage [159], skeletal muscle [78], cardiac [160], vascular [161], and neural tissues [162]. Nanofibers exist in every branch of the medical sector, which contributes to several fields such as tissue engineering [163,164], regenerative medicine [165], and sensing and biomedical approaches [166].…”

Section: Most Common Applications Of Nanofibersmentioning

confidence: 99%

“…Nanofibers exist in every branch of the medical sector, which contributes to several fields such as tissue engineering [163,164], regenerative medicine [165], and sensing and biomedical approaches [166]. These applications may involve drug delivery carriers [30], wound dressing [167], and facemasks [168]. These nanofibers are useful for tissue regeneration by mimicking a porous topography, enhancing the adhesion cells, and improving physiological acceptability and mechanical strength [169].…”

Section: Most Common Applications Of Nanofibersmentioning

confidence: 99%

See 1 more Smart Citation

Biotechnology of Nanofiber in Water, Energy, and Food Sectors

Prokisch,

Sári,

Muthu

et al. 2023

Agronomy

View full text Add to dashboard Cite

Natural resources including water, energy, and food have an increase in demand due to the global population increases. The sustainable management of these resources is an urgent global issue. These resources combined in a very vital nexus are called the water–energy–food (WEF) nexus. The field of nanotechnology offers promising solutions to overcome several problems in the WEF nexus. This review is the first report that focuses on the suggested applications of nanofibers in the WEF sectors. An economic value of nanofibers in WEF sectors was confirmed, which was mainly successfully applied for producing clean water, sustainable energy, and safe food. Biotechnological solutions of nanofibers include various activities in water, energy, and food industries. These activities may include the production of fresh water and wastewater treatment, producing, converting, and storing energy, and different activities in the food sector. Furthermore, microbial applications of nanofibers in the biomedicine sector, and the most important biotechnological approaches, mainly plant tissue culture, are the specific focus of the current study. Applying nanofibers in the field of plant tissue culture is a promising approach because these nanofibers can prevent any microbial contamination under in vitro conditions, but the loss of media by evaporation is the main challenge in this application. The main challenges of nanofiber production and application depend on the type of nanofibers and their application. Different sectors are related to almost all activities in our life; however, enormous open questions still need to be answered, especially the green approach that can be used to solve the accumulative problems in those sectors. The need for research on integrated systems is also urgent in the nexus of WEF under the umbrella of environmental sustainability, global climate change, and the concept of one’s health.

show abstract

“…With the continuous development of the nano era, it has gradually become a major direction of study to apply nanomaterials in drug delivery systems [ 51 ]. Electrospun fibers have been broadly applied in drug delivery [ 52 , 53 , 54 , 55 , 56 , 57 ]. This is because the drug in the fibers exists in an amorphous form, which effectively improves the solubility and bioavailability of insoluble drugs.…”

Section: Introductionmentioning

confidence: 99%

Engineered Shellac Beads-on-the-String Fibers Using Triaxial Electrospinning for Improved Colon-Targeted Drug Delivery

et al. 2023

View full text Add to dashboard Cite

Colon-targeted drug delivery is gradually attracting attention because it can effectively treat colon diseases. Furthermore, electrospun fibers have great potential application value in the field of drug delivery because of their unique external shape and internal structure. In this study, a core layer of hydrophilic polyethylene oxide (PEO) and the anti-colon-cancer drug curcumin (CUR), a middle layer of ethanol, and a sheath layer of the natural pH-sensitive biomaterial shellac were used in a modified triaxial electrospinning process to prepare beads-on-the-string (BOTS) microfibers. A series of characterizations were carried out on the obtained fibers to verify the process–shape/structure–application relationship. The results of scanning electron microscopy and transmission electron microscopy indicated a BOTS shape and core–sheath structure. X-ray diffraction results indicated that the drug in the fibers was in an amorphous form. Infrared spectroscopy revealed the good compatibility of the components in the fibers. In vitro drug release revealed that the BOTS microfibers provide colon-targeted drug delivery and zero-order drug release. Compared to linear cylindrical microfibers, the obtained BOTS microfibers can prevent the leakage of drugs in simulated gastric fluid, and they provide zero-order release in simulated intestinal fluid because the beads in BOTS microfibers can act as drug reservoirs.

show abstract

Application of Electrospun Nanofiber as Drug Delivery Systems: A Review

Cited by 11 publications

References 132 publications

Electrospun Nanofiber Scaffold for Skin Tissue Engineering: A Review

Electrospun Nanofiber Scaffold for Skin Tissue Engineering: A Review

Biotechnology of Nanofiber in Water, Energy, and Food Sectors

Engineered Shellac Beads-on-the-String Fibers Using Triaxial Electrospinning for Improved Colon-Targeted Drug Delivery

Contact Info

Product

Resources

About