Application of Fourier transform Raman spectroscopy to a range of compounds of pharmaceutical interest

Cutmore, E. A.; Skett, Peter W.

doi:10.1016/0584-8539(93)80105-j

Cited by 23 publications

(10 citation statements)

References 17 publications

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“…Raman spectra are complementary to IR and are a useful adjunct for vibrational analysis studies. 27,28 A vibrational mode is generally IR-active if the molecular dipole moment changes during the vibration, and is Raman-active if there is a change in polarizability. Although stretching vibrations of completely symmetric bonds do not alter the dipole moment, the polarizability is changed, so that important vibrations in tranilast (such as C --C stretches) may be observed with Raman spectroscopy.…”

Section: Spectroscopic Analysismentioning

confidence: 99%

Structural analysis of polymorphism and solvation in tranilast

Vogt

Cohen

Bowman

et al. 2005

Journal of Pharmaceutical Sciences

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Section: Spectroscopic Analysismentioning

confidence: 99%

Structural analysis of polymorphism and solvation in tranilast

Vogt

Cohen

Bowman

et al. 2005

Journal of Pharmaceutical Sciences

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“…The application of Fourier transform Raman (FT-Raman) spectroscopy in food (Ozaki et al 1992) and pharmaceuticals (Cutmore & Skett 1993) is gaining acceptance, because of its excellent frequency precision, good signal-to-noise ratio and minimal data acquisition time (Schrader 1996). Like MIR spectra, FT-Raman spectra can provide chemical ® ngerprints of functional groups in the sample.…”

Section: Introductionmentioning

confidence: 99%

Rapid determination of vitamin C by NIR, MIR and FT-Raman techniques

Yang

Irudayaraj

2002

Journal of Pharmacy and Pharmacology

105

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Rapid spectroscopic determination of vitamin C in food and pharmaceutical products using infrared and Raman techniques was proposed. In this study, near-infrared (NIR), Fourier transform near-infrared (FT-NIR), Fourier transform infrared-attenuated total reflectance (FTIR-ATR), diffuse reflectance (DRIFTS), Fourier transform infrared-photoacoustic (FTIR-PAS) and FT-Raman spectroscopy were used in conjunction with partial least squares (PLS) regression to quantify vitamin C in powdered mixtures and solutions. Results indicate that the methods adopted have high prediction correlation. R2 values were 0.999 for FTIR-ATR, 0.976 for DRIFTS, 0.966 for FTIR-PAS, 0.988 for NIR, 0.992 for FT-NIR and 0.95 for FT-Raman, with an overall prediction error of 0.2-3.0%. The time required to complete an experiment ranged from 5 s (NIR) to 3 min (FT-Raman). The FTIR and FT-Raman techniques can be complementary tools for qualitative and quantitative characterization of the samples. Infrared and Raman techniques can be used to quantify vitamin C in foods and pharmaceutical products.

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“…Spectroscopic techniques, such as X-ray [1][2][3][4][5], infrared (IR) and Raman [6][7][8][9], UV-vis [10][11][12], nuclear magnetic resonance (NMR) [13][14][15], and EPR [16][17][18][19] spectroscopies are versatile tools for chemical analysis, particularly in the pharmaceutical and biopharmaceutical fields. Many of these spectroscopic techniques are routinely utilized in drug applications, such as characterizing formulations or elucidating the kinetic processes associated with drug delivery.…”

Section: Introductionmentioning

confidence: 99%