Application of FTIR Spectroscopic Imaging to Study the Effects of Modifying the pH Microenvironment on the Dissolution of Ibuprofen from HPMC Matrices

A Fast and Reliable Empirical Approach for Estimating Solubility of Crystalline Drugs in Polymers for Hot Melt Extrusion Formulations

“…To further confirm that approximately 40 wt % of ibuprofen indeed dissolves in the polymer at room temperature, FTIR imaging was performed on the cryomilled mixtures after 2 years of storage at room temperature. With FTIR imaging, the local distribution of the individual formulation components can be visualized as “chemical map” using false color images . In Figure b, the spatial distribution of total ibuprofen (i.e., amorphous and crystalline forms) and crystalline ibuprofen is shown.…”

“…With FTIR imaging, the local distribution of the individual formulation components can be visualized as "chemical map" using false color images. 33 In Figure 4b, the spatial distribution of total ibuprofen (i.e., amorphous and crystalline forms) and crystalline ibuprofen is shown.…”

FT‐IR Imaging in ATR and Transmission Modes: Practical Considerations and Emerging Applications

“…ATR FT-IR spectroscopic imaging has been shown to be a valuable asset in such studies and has allowed insight to be gained into many processes including drug polymorphism [30,34,82]; the effect of polymer swelling [9], pH (of the dissolution media) [79], the micro-environement [83], or the drug loading and sample preparation [73,84] on drug release. ATR FT-IR spectroscopic imaging has been shown to be a valuable asset in such studies and has allowed insight to be gained into many processes including drug polymorphism [30,34,82]; the effect of polymer swelling [9], pH (of the dissolution media) [79], the micro-environement [83], or the drug loading and sample preparation [73,84] on drug release.…”

“…Nicotinamide formulations of 60% and 10% (w/w) in HPMC were prepared and studied by FT-IR imaging and UV-vis. This led to the pH of the matrix microenvironment being shown, by ATR FT-IR imaging, to affect the crystallization process of ibuprofen during dissolution [83]. It was thus shown that FT-IR imaging offers benefits to the development and validation of models for drug release and physical properties by allowing a straightforward method to obtain component physical properties that are spatially resolved.…”

Study of the Homogeneity of Drug Loaded in Polymeric Films Using Near-Infrared Chemical Imaging and Split-Plot Design

“…Chemical imaging (CI) coupled with vibrational spectroscopy [essentially Mid‐infrared, near‐infrared (NIR), and Raman] allows further analytical characterization of solid dosage forms of pharmaceuticals, and it has been encouraged by US FDA's process analytical technology to ensure quality control over pharmaceutical processes . CI provides unique spectral information with spatial resolution (i.e., the sample region of interest is split in regular squares, denominated pixels, that possess their own spectra), and this analytical methodology has been exploited during numerous pharmaceutical process applications, such as the chemical distribution of the ingredients, blend homogeneity, coating, polymorphism, authentication, and dissolution …”