Application of high frequency color Doppler ultrasound in the monitoring of rheumatoid arthritis treatment

Zheng, Guimin; Wang, Lei; Xing, Jia; Li, Fang; Yan, Yonglong; Yu, Zhaojie; Li, Li; Wei, Qun; Zhang, Fengxiao

doi:10.3892/etm.2014.2001

Cited by 8 publications

(5 citation statements)

References 33 publications

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“…RA is a symmetrical, chronic inflammatory disease primarily affecting multiple small peripheral joints, with possible extra-articular systemic damage (14). RA patients may suffer from pain, numbness, weight gain, difficulty in joint flexion and extension, joint swelling and a burning sensation in the muscles, bones and joints (15).…”

Section: Discussionmentioning

confidence: 99%

Paeoniflorin ameliorates rheumatoid arthritis in rat models through oxidative stress, inflammation and cyclooxygenase 2

Jia

2015

Experimental and Therapeutic Medicine

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Paeoniflorin has anti-inflammatory, anti-allergy, immune regulatory and pain-relieving effects, amongst other roles. However, the mechanisms underlying the protective effects of paeoniflorin on rheumatoid arthritis (RA) remain under investigation; the objective of the current study was to evaluate these protective effects in the context of an RA model. Rats were randomly divided into 5 groups, as follows: The control group, the RA rat model group, and the paeoniflorin groups, in which paeoniflorin was administered at concentrations of 5, 10 and 20 mg/kg for 3 weeks. The pain thresholds and arthritic symptoms of the RA rats were measured. Oxidative stress and inflammatory cytokines were also analyzed and western blot analysis was used to evaluate cyclooxygenase-2 (COX-2) protein expression levels. Paeoniflorin significantly increased the pain threshold and decreased the arthritic symptoms in the RA rat model. Notably, paeoniflorin reduced the malondialdehyde concentration and increased the activity of superoxide dismutase, catalase and glutathione peroxidase. Furthermore, paeoniflorin attenuated the activity of nuclear factor-κB p65 unit, tumor necrosis factor-α, interleukin (IL)-1β and IL-6, and reduced the COX-2 protein expression level. The present study indicates that paeoniflorin ameliorates disease in rat models of RA through oxidative stress, inflammation and alterations to COX-2 expression.

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Section: Discussionmentioning

confidence: 99%

Paeoniflorin ameliorates rheumatoid arthritis in rat models through oxidative stress, inflammation and cyclooxygenase 2

Jia

2015

Experimental and Therapeutic Medicine

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“…[ 34 ] There was less experience of intranerval blood flow than rheumatoid synovitis. [ 38 , 39 ] The main reason is that the blood flow of nerve is more small and slow.…”

Section: Discussionmentioning

confidence: 99%

Value of superb microvascular imaging ultrasonography in the diagnosis of carpal tunnel syndrome

Chen

et al. 2017

Medicine

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The aim of this study was to compare the value of superb microvascular imaging (SMI) in carpal tunnel syndrome (CTS) with that of color Doppler ultrasonography (CDUS) and power Doppler ultrasonography (PDUS).Fifty patients with symptomatic CTS and 25 healthy volunteers were enrolled. The cross-sectional area (CSA), CDUS score, PDUS score, and SMI score of the median nerve (MN) at the carpal tunnel were recorded. The value of different ultrasonography (US) diagnostic strategies was calculated.The blood flow display ratio in the MN of the healthy volunteers had no statistical difference between CDUS, PDUS, and SMI (20%, 32%, and 48%, respectively, P >.05). The blood flow display ratio for SMI in patients was significantly higher than that of CDUS and PDUS (90%, 52%, and 60%, respectively, P <.005). The accuracy of SMI score ≥2 (79%) was much higher than that of CDUS and PDUS (61% and 63%, respectively, P <.05). Comprehensive consideration of SMI and CSA, CSA≥10.5 mm2, and/or SMI score ≥2 has the highest accuracy (83%), significantly higher than that of CSA combination with CDUS or PDUS (68% and 69%, respectively, P <.05).SMI is more sensitive to display the blood flow in the MN with CTS than CDUS and PDUS. It might significantly improve the diagnosis value for CTS.

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“…In a previous study, Zheng et al (11) confirmed that US examination was feasible and capable of predicting RA disease, as measured by the disease activity score in 28 joints for the evaluation of joints. Furthermore, McQueen et al (12) have previously indicated that US is able to detect bone erosion with 95% specificity and 78% predictive accuracy, with a bone volume loss of >20% in US-accessible areas, such as in the dorsal and palmar aspects of MCP joints.…”

Section: Introductionmentioning

confidence: 97%

Diagnostic value of high-frequency ultrasound and magnetic resonance imaging in early rheumatoid arthritis

Wang

Sun

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Early diagnosis and management improve the outcome of patients with rheumatoid arthritis (RA). The present study explored the application of high-frequency ultrasound (US) and magnetic resonance imaging (MRI) in the detection of early RA. Thirty-nine patients (20 males and 19 females) diagnosed with early RA were enrolled in the study. A total of 1,248 positions, including 858 hand joints and 390 tendons, were examined by high-frequency US and MRI to evaluate the presence of bone erosion, bone marrow edema (BME), synovial proliferation, joint effusion, tendinitis and tendon sheath edema. The imaging results of the above abnormalities, detected by US, were compared with those identified using MRI. No statistically significant overall changes were observed between high-frequency US and MRI in detecting bone erosion [44 (5.1%) vs. 35 (4.1%), respectively; P>0.05], tendinitis [18 (4.6%) vs. 14 (1.5%), respectively; P>0.05] and tendon sheath edema [37 (9.5%) vs. 30 (7.7%), respectively; P>0.05]. Significant differences were observed between high-frequency US and MRI with regards to the detection of synovial proliferation [132 (15.4%) vs. 66 (7.7%), respectively; P<0.05] and joint effusion [89 (10.4%) vs. 52 (6.1%), respectively; P<0.05]. In addition, significant differences were identified between the detection of BME using MRI compared with high-frequency US (5.5 vs. 0%, respectively; P<0.05). MRI and high-frequency US of the dominant hand and wrist joints were comparably sensitive to bone erosion, tendinitis and tendon sheath edema. However, MRI was more sensitive in detecting bone marrow edema in early RA, while US was more sensitive in the evaluation of joint effusion and synovial proliferation. In conclusion, US and MRI are promising for the detection and diagnosis of inflammatory activity in patients with RA.

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Application of high frequency color Doppler ultrasound in the monitoring of rheumatoid arthritis treatment

Cited by 8 publications

References 33 publications

Paeoniflorin ameliorates rheumatoid arthritis in rat models through oxidative stress, inflammation and cyclooxygenase 2

Paeoniflorin ameliorates rheumatoid arthritis in rat models through oxidative stress, inflammation and cyclooxygenase 2

Value of superb microvascular imaging ultrasonography in the diagnosis of carpal tunnel syndrome

Diagnostic value of high-frequency ultrasound and magnetic resonance imaging in early rheumatoid arthritis

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