Application of Mid-Infrared Transmission Spectrometry to the Direct Determination of Glucose in Whole Blood

Vonach, R.; Buschmann, Julia; Falkowski, R.; Schindler, R.; Lendl, Bernhard; Kellner, Robert

doi:10.1366/0003702981944553

Cited by 63 publications

(49 citation statements)

References 10 publications

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“…The selectivity of this technology is based on the same principle as the selectivity of the absorption spectroscopy method for analyte measurements. Glucose has very welldefined spectral features in the fingerprint IR region as shown (for example, in the studies by Heise et al [7] and Vonach et al [10] and in our plasma thermal emission spectra plots Fig. 2).…”

Section: Noninvasive Glucose Monitor Technologysupporting

confidence: 82%

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A Novel Noninvasive Blood Glucose Monitor

Malchoff

Shoukri²,

Landau³

et al. 2002

Diabetes Care

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OBJECTIVE -To evaluate the precision and accuracy of a new advanced prototype of a noninvasive blood glucose monitor across a wide range of serum glucose concentrations.RESEARCH DESIGN AND METHODS -An advanced handheld noninvasive glucose monitor prototype was calibrated and tested using patients recruited by the General Research Center of the University of Connecticut Health Center. The monitor, developed by Infratec, uses principles of thermal emission spectroscopy. The noninvasive measurement of tympanic membrane glucose concentration was calibrated to the serum glucose concentration using 432 paired measurements from 20 subjects with insulin-requiring diabetes. This calibration was subsequently tested (results of power analyses) in a blind fashion with 126 paired measurements from six diabetic subjects who require insulin.RESULTS -In vivo measurements demonstrated the reproducibility of the methodology of the noninvasive glucose monitor. Based on the calibration model, predicted glucose concentrations for six subjects were as follows (for 126 data points): SD ϭ 32 mg/dl, mean absolute relative error (%MARE) ϭ 11.6, with a correlation coefficient of r ϭ 0.87. Noninvasive glucose results were also compared with laboratory reference measurements using an error-in-variables method. Clark error grid analysis showed that 100% of the measurements fell within zones A and B (90% in zone A and 10% in zone B). The SD for all noninvasive measured concentrations was 27 mg/dl, %MARE was 8.6, and the correlation coefficient was r ϭ 0.94.CONCLUSIONS -This first independent clinical study of an advanced noninvasive blood glucose prototype based on thermal emission in the mid-infrared spectral region has demonstrated glucose measurements with clinically acceptable accuracy but without the necessity of individual daily calibration. Diabetes Care 25:2268 -2275, 2002T here are a number of reviews (1,2) on approaches for noninvasive blood glucose (BG) measurements. In recent years, infrared (IR) spectroscopy has emerged as the analytical method of choice, founded on the spectrum of IR colors characteristic of the analyte itself instead of relying on reagents and color reactions. Different approaches in IR absorption are described in several published studies (3-10).The advanced prototype presented here is based on thermal emission spectroscopy (TES) (11-18) and promises a new generation of noninvasive human tissue analyte instruments. This methodology is fundamentally different from previous attempts at using near-IR techniques (1). The method and instrument are based on the discovery that natural mid-IR emission from the human body, especially from the tympanic membrane, is modulated by the state of the emitting tissue. Spectral emissivity of human IR radiation from the tympanic membrane consists of spectral information of the blood analyte. This can be directly correlated with the blood analyte concentration (for example, the glucose concentration). Tympanic membrane thermometers, currently widely used at home and in the hospit...

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Section: Noninvasive Glucose Monitor Technologysupporting

confidence: 82%

“…In recent years, infrared (IR) spectroscopy has emerged as the analytical method of choice, founded on the spectrum of IR colors characteristic of the analyte itself instead of relying on reagents and color reactions. Different approaches in IR absorption are described in several published studies (3)(4)(5)(6)(7)(8)(9)(10).…”

mentioning

confidence: 99%

A Novel Noninvasive Blood Glucose Monitor

Malchoff

Shoukri²,

Landau³

et al. 2002

Diabetes Care

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“…Com esta metodologia, tem sido possível obter dados de quantificação simultânea, rápida e de baixo custo de componentes bioquímicos oriundos de fluidos biológicos e tecidos humanos em diversas condições fisiológicas e patológicas. Um exemplo é a determinação de glicose sanguínea, plasmática ou sérica usando técnicas como transmissão e reflexão total atenuada (ATR) nas regiões do infravermelho médio (MIR) ou próximo (NIR), visando à triagem e monitoramento de pacientes com diabetes JANATSCH et al, 1989;HEISE et al, 1994;HEISE & BITTNER, 1998;SHAW et al, 1998;VONACH et al, 1998;WERNER et al, 1998;PETRICH et al, 2000;LOW-YING et al, 2002;PETRICH et al, 2002).…”

Section: Fundamentação Teóricaunclassified

“…Justifica-se visto a importância destes no diagnóstico e manutenção da DM com espectro infravermelho, com objetivo de prever os valores encontrados a partir dos testes de referência. JANATSCH et al, 1989;HEISE et al, 1994;HEISE & BITTNER, 1998;SHAW et al, 1998;VONACH et al, 1998;WERNER et al, 1998;PETRICH et al, 2000;LOW-YING et al, 2002;PETRICH et al, 2002) porém com erros de previsão menores.…”

Section: Fundamentação Teóricaunclassified

Avaliação De A1c E Glicose Por Drifts: Uma Nova Abordagem Analítica Para Diagnóstico De Diabetes Mellitus

Severo

Caetano²,

Horta

et al. 2014

RJP

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RESUMOO diabetes mellitus (DM) inclui um grupo de doenças metabólicas resultante de disfunção na secreção e/ou ação da insulina. O diagnóstico de DM é definido com base na avaliação da glicemia de jejum (GJ) e hemoglobina glicada (A 1C ), que também informa a persistência da hiperglicemia. Entretanto, novas tecnologias analíticas estão sempre sob constante investigação. A espectroscopia de absorção molecular no infravermelho com Transformada de Fourier (FT-IR) associada à análise multivariada tem surgido como uma alternativa nesse contexto. O presente estudo buscou avaliar a FT-IR, através da técnica de reflectância difusa, para quantificar glicose e A 1C em um grupo de indivíduos adultos. O estudo foi composto por 46 pacientes de 32 a 59 anos, com valores GJ de 71,67 a 135 mg/dL e de A 1C de 5,3 a 7,2 %. O modelo PLS-DRIFTS para GJ apresentou RMSECV=1,37 mg/dL e R²=0,995 e para A 1C , RMSECV=0,06% R²=0,993, sem exclusão de amostras e usando a faixa de 4000-2401, 2300-600 cm -1 . Dessa forma foi possível concluir que FT-IR associada à análise multivariada se mostrou adequada para predizer os parâmetros bioquímicos de glicose e A 1C de jejum com um erro mínimo, atendendo aos requisitos analíticos da ANVISA para quantificação destes parâmetros. Palavras-chave:Hiperglicemia. Espectroscopia no Infravermelho. Metabolômica. Diabetes Mellitus. ABSTRACTDiabetes mellitus (DM) includes a group of metabolic diseases resulting from dysfunction in the secretion and/or insulin action. The diagnosis of DM is defined based on the evaluation of fasting glucose (FPG) and glycosylated hemoglobin (A 1C ), which also shows the persistence of hyperglycemia. However, new analytical technologies are always under constant investigation. The molecular absorption infrared spectroscopy with Fourier-transformed (FT-IR) associated with multivariate analysis has emerged as an alternative in this context. The present study sought to evaluate the FT-IR, through the technique of diffuse reflectance, to quantify glucose and A 1C in a group of adults. The study comprised 46 patients 32-59 years-

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“…Thus, accurate and reliable measurements can be performed without complicated calculations to remove interference between the peaks. There have been many reports of applying MIR-ATR methods for blood glucose measurement including ones measuring glucose levels of whole blood, [8][9][10] urine, 11 and serum. 12,13 Some groups reported that they have attempted to measure blood glucose levels in vivo by using an ATR prism with MIR lasers 14,15 and an FT-IR spectrometer.…”

Section: Introductionmentioning

confidence: 99%

Blood glucose measurement by using hollow optical fiber-based attenuated total reflection probe

2014

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Abstract. A noninvasive glucose monitoring system based on mid-infrared, attenuated total reflection spectroscopy using a hollow optical fiber probe is developed. Owing to the flexible fiber probe, measurement of oral mucosa, where blood capillaries are near the skin surface, is possible. Blood glucose levels are measured by detecting the peak intensity of glucose absorption bands, and the experimental results showed that the reproducibility of the measurement is high enough for monitoring blood glucose. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Application of Mid-Infrared Transmission Spectrometry to the Direct Determination of Glucose in Whole Blood

Cited by 63 publications

References 10 publications

A Novel Noninvasive Blood Glucose Monitor

A Novel Noninvasive Blood Glucose Monitor

Avaliação De A1c E Glicose Por Drifts: Uma Nova Abordagem Analítica Para Diagnóstico De Diabetes Mellitus

Blood glucose measurement by using hollow optical fiber-based attenuated total reflection probe

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