Application of optical dispersion measurements using small-angle laser scattering for standardization and quality control of medicinal preparations

Rapid determination of the identity of aqueous drug solutions

“…The beam from a He-Ne laser (LGN-208A, 1.9 mW power, 780 nm wavelength, 0.6 mm laser beam diameter at 40 mm, 0.06 mm linear deviation of the beam relative to the geometric axis of the incident sites) was passed through a system of lenses, from which the sample was situated at a certain distance [1]. The optical pattern was projected onto a monitor screen using a digital camera connected through a USB cable to a PC (Fig.…”

“…The increasing demand for drug infusion solutions such as isotonic saline, Ringer solution, etc., has stimulated the development and incorporation into pharmaceutical analysis of new methods for determining their identity [1]. Determining the identity of infusion solutions without violating the integrity of the packaging increases the speed of the method.…”

“…This, in turn, should cause the formation of GHC of different sizes and with different relaxation properties [8]. 1 Our goal was to study the relaxation kinetics of GHCs of water in samples of sodium chloride isotonic solution and to develop a method for determining the identity of aqueous drug solutions without violating the integrity of the packaging. (Saransk) batches 7130708 and 6940708; and OAO Biosintez (Penza) batches 5220908 and 6190908] that were acquired in drugstores of Moscow Oblast.…”

Laser diffraction for standardization of heterogeneous pharmaceutical preparations

“…Particle size distribution in heterogeneous systems is studied in various fields of science from colloidal chemistry and oceanography to cytology and pharmaceutical chemistry [1][2][3][4][5][6].…”

Application of low-angle laser scattering to the quality control of pharmaceutical powders and suspensions. 2. Barium sulfate

“…We have previously used low-angle laser light scattering to assess the quality of infusions, aging of which is accompa- nied by loss of homogeneity [5]. The present report describes studies of barium sulfate preparations from different manufacturers, the use of which in gastrointestinal tract radiography requires strict control of the degree of dispersity.…”