Application of robotic-assisted in situ 3D printing in cartilage regeneration with HAMA hydrogel: An in vivo study

Ma, Kaiwei; Zhao, Tianzheng; Lijun, Yang; Wang, Peng; Jin, Jing; Teng, Huajian; Xia, Dan; Zhu, Linli; Li, Lan; Jiang, Qing; Wang, Xingsong

doi:10.1016/j.jare.2020.01.010

Cited by 124 publications

(73 citation statements)

References 31 publications

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“…Hyaluronic acid methacrylate[ 176 , 177 ], a photo-cross-linkable version of hyaluronic acid, also holds a place in the top-ten list. This is not a surprise as hyaluronic acid is a major component of the extracellular matrix of cartilage and bone, the most bioprinted tissues today[ 177 , 178 ].…”

Section: Bioinks For Different Bioprinting Technologiesmentioning

confidence: 99%

Bioinks for 3D Bioprinting: A Scientometric Analysis of Two Decades of Progress

Pedroza-González¹,

Rodríguez-Salvador²,

Pérez-Benítez³

et al. 2024

IJB

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This scientometric analysis of 393 original papers published from January 2000 to June 2019 describes the development and use of bioinks for 3D bioprinting. The main trends for bioink applications and the primary considerations guiding the selection and design of current bioink components (i.e., cell types, hydrogels, and additives) were reviewed. The cost, availability, practicality, and basic biological considerations (e.g., cytocompatibility and cell attachment) are the most popular parameters guiding bioink use and development. Today, extrusion bioprinting is the most widely used bioprinting technique. The most reported use of bioinks is the generic characterization of bioink formulations or bioprinting technologies (32%), followed by cartilage bioprinting applications (16%). Similarly, the cell-type choice is mostly generic, as cells are typically used as models to assess bioink formulations or new bioprinting methodologies rather than to fabricate specific tissues. The cell-binding motif arginine-glycine-aspartate is the most common bioink additive. Many articles reported the development of advanced functional bioinks for specific biomedical applications; however, most bioinks remain the basic compositions that meet the simple criteria: Manufacturability and essential biological performance. Alginate and gelatin methacryloyl are the most popular hydrogels that meet these criteria. Our analysis suggests that present-day bioinks still represent a stage of emergence of bioprinting technology.

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Section: Bioinks For Different Bioprinting Technologiesmentioning

confidence: 99%

Bioinks for 3D Bioprinting: A Scientometric Analysis of Two Decades of Progress

Pedroza-González¹,

Rodríguez-Salvador²,

Pérez-Benítez³

et al. 2024

IJB

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“…Based on the results, the osteochondral injury could be repaired as about 60 s, and the regenerated cartilage tissue exhibited the same biomechanical and biochemical performance in hydrogel implantation and in situ 3D bioprinting. It was observed that the presented method is very suitable for surgical procedure improvement, as well as enhancing cartilage rehabilitation [218].…”

Section: Review Biomaterials Sciencementioning

confidence: 91%

Recent progress in extrusion 3D bioprinting of hydrogel biomaterials for tissue regeneration: a comprehensive review with focus on advanced fabrication techniques

et al. 2021

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“…The future of cartilage and knee therapies seems to be promising by the application of in vivo 3D-printing strategies and using biological substances to provide appropriate cell adhesion and proliferation in the defected site. [135] Several strategies applying such a method (e.g., autologous chondrocyte transplantation and collagen-induced techniques) have been studied. However, these evolving approaches may not be proper yet for being used to induce the regeneration of end-stage osteochondral injuries, where implants are mandatory not only for correcting articular surface problems but also for healing limb alignment and knee joint geometry.…”

Section: Robotic-assisted 3d Bioprinting and Simultaneous 3d Scanningmentioning

confidence: 99%

Hydrogel‐Based 3D Bioprinting for Bone and Cartilage Tissue Engineering

Abdollahiyan

Oroojalian

Mokhtarzadeh

et al. 2020

Biotechnology Journal

112

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As a milestone in soft and hard tissue engineering, a precise control over the micropatterns of scaffolds has lightened new opportunities for the recapitulation of native body organs through three dimentional (3D) bioprinting approaches. Well-printable bioinks are prerequisites for the bioprinting of tissues/organs where hydrogels play a critical role. Despite the outstanding developments in 3D engineered microstructures, current printer devices suffer from the risk of exposing loaded living agents to mechanical (nozzle-based) and thermal (nozzle-free) stresses. Thus, tuning the rheological, physical, and mechanical properties of hydrogels is a promising solution to address these issues. The relationship between the mechanical characteristics of hydrogels and their printability is important to control printing quality and fidelity. Recent developments in defining this relationship have highlighted the decisive role of main additive manufacturing strategies. These strategies are applied to enhance the printing quality of scaffolds and determine the nurture of cellular morphology. In this regard, it is beneficial to use external and internal stabilization, photocurable biopolymers, and cooling substrates containing the printed scaffolds. The objective of this study is to review cutting-edge developments in hydrogel-type bioinks and discuss the optimum simulation of the zonal stratification in osteochondral and cartilage units.

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Application of robotic-assisted in situ 3D printing in cartilage regeneration with HAMA hydrogel: An in vivo study

Cited by 124 publications

References 31 publications

Bioinks for 3D Bioprinting: A Scientometric Analysis of Two Decades of Progress

Bioinks for 3D Bioprinting: A Scientometric Analysis of Two Decades of Progress

Recent progress in extrusion 3D bioprinting of hydrogel biomaterials for tissue regeneration: a comprehensive review with focus on advanced fabrication techniques

Hydrogel‐Based 3D Bioprinting for Bone and Cartilage Tissue Engineering

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