Developed economic - ecological model of modern large city on the example of Almaty, based on the main provisions of statistical theory, theories of logistics and the similarity of the General plan of development of Kazakhstan megapolis, the strategy of transport development of Kazakhstan, programs to reduce the traffic load on the highways regulations of international and national importance, as well as on the basis of predictive decisions arising from the comprehensive consideration of the issues city transport road ecology (CTRE). It includes for the first time scientifically grounded ecological and economic indicators and daily ecological model of Almaty which were initial data for further researches and calculations. However, this complex problem practically in all textbooks and manuals on ecology is considered factually, i.e. separately without interrelation, and questions of interrelation or mutual influence of emissions of motor transport in aggregate with infrastructure SRN (traffic lights, intersections, sidewalks, avenues, etc.) on environment are not still considered in the world literature. Besides there are no data on distribution of exhaust gases (EG) of motor vehicle in the residential area near highways in any source. Therefore, even it is difficult to expert to define the main sources of pollution of urban air environment.