Application of thermal analysis to the study of antituberculosis drugs–excipient compatibility

Lavor, Edilene P.; Navarro, Marco V. M.; Freire, Fátima Duarte; Aragão, Cícero Flávio Soares; Raffin, Fernanda Nervo; Barbosa, Euzébio Guimarães; Moura, Túlio Flávio Accioly de Lima e

doi:10.1007/s10973-013-3050-2

Cited by 41 publications

(35 citation statements)

References 14 publications

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“…FTIR spectra were obtained between 4000 and 700 cm −1 using 16 scans and spectral resolution of 4 cm −1 . To compare different spectra, a spectral correlation study was performed with an ad hoc algorithm through spectral overlap, as described by Lavor et al [ 44 ]. Based on the individual spectra of CMO and CDs, a combined spectrum was created consisting on the sum of the CMO and CD spectra, resulting in the theoretical physical mixture (TPM) spectrum, in which there is no interaction between CMO and each CD.…”

Section: Methodsmentioning

confidence: 99%

Inclusion Complexes of Copaiba (Copaifera multijuga Hayne) Oleoresin and Cyclodextrins: Physicochemical Characterization and Anti-Inflammatory Activity

Pinheiro

Tavares

Silva

et al. 2017

IJMS

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Complexation with cyclodextrins (CDs) is a technique that has been extensively used to increase the aqueous solubility of oils and improve their stability. In addition, this technique has been used to convert oils into solid materials. This work aims to develop inclusion complexes of Copaifera multijuga oleoresin (CMO), which presents anti-inflammatory activity, with β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) by kneading (KND) and slurry (SL) methods. Physicochemical characterization was performed to verify the occurrence of interactions between CMO and the cyclodextrins. Carrageenan-induced hind paw edema in mice was carried out to evaluate the anti-inflammatory activity of CMO alone as well as complexed with CDs. Physicochemical characterization confirmed the formation of inclusion complex of CMO with both β-CD and HP-β-CD by KND and SL methods. Carrageenan-induced paw edema test showed that the anti-inflammatory activity of CMO was maintained after complexation with β-CD and HP-β-CD, where they were able to decrease the levels of nitrite and myeloperoxidase. In conclusion, this study showed that it is possible to produce inclusion complexes of CMO with CDs by KND and SL methods without any change in CMO’s anti-inflammatory activity.

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Section: Methodsmentioning

confidence: 99%

Inclusion Complexes of Copaiba (Copaifera multijuga Hayne) Oleoresin and Cyclodextrins: Physicochemical Characterization and Anti-Inflammatory Activity

Pinheiro

Tavares

Silva

et al. 2017

IJMS

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“…For instance, Pearson's correlation coefficients (r) between the theoretical and experimental API-excipient FTIR spectra were calculated [14][15][16]. The deviation from unity was interpreted as an indication of problems.…”

Section: Introductionmentioning

confidence: 99%

Compatibility studies of hydrocortisone with excipients using thermogravimetric analysis supported by multivariate statistical analysis

Rojek

Wesołowski

2016

J Therm Anal Calorim

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Application of thermogravimetry (TG) alone to study compatibility/incompatibility of active pharmaceutical ingredients (APIs) with excipients yields to misleading results due to overlapping of the thermal stages in the course of decomposition of both ingredients and their pharmaceutical mixtures. Hence, the purpose of this study was to assess the usefulness of multivariate statistical analysis as a supporting tool for interpretation of the TG traces during assessing compatibility of hydrocortisone as an API with selected excipients (mannitol, starch, lactose, methylcellulose, b-cyclodextrin, meglumine, chitosan, magnesium stearate and polyvinylpyrrolidone). The results show that two multivariate techniques, principal component analysis (PCA) and cluster analysis (CA), can be successfully used for interpretation of TG traces, while the TG is used alone as a screening technique to assess compatibility. The results obtained by using TG analysis, supported by PCA and CA, were approved by those of differential scanning calorimetry, infrared spectroscopy and X-ray powder diffraction. Incompatibilities were only found in mixtures of hydrocortisone with magnesium stearate and b-cyclodextrin.

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“…Since isoniazid have a primary amine group bound to a secondary nitrogen of the acetamide group, it is likely that this drug could undergo Maillard-type reactions under optimal conditions. In studies conducted by Lavor et al 15 the onset temperature of the first decomposition step of the mixture on the TG/DTG curves decreased 30ºC compared to that of pure INH, suggesting strong interaction between INH and LAC. The incompatibility between isoniazid and lactose was confirmed by differential scanning calorimetry (DSC) and high performance liquid chromatography.…”

Section: Thermal Analysis Assaysmentioning

confidence: 90%

“…15, 16 Chadha and Bandhari 17 suggest a combination of thermal and nonthermal methods to successful in proper identification of incompatibility.…”

Section: Introductionmentioning

confidence: 99%

Compatibility Study Between Isoniazid and Pharmaceutical Excipients Used in Solid Dosage Forms

Tibola¹,

Rodrigues²

2017

Int. Res. J. Pharm.

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The compatibility between isoniazid (INH) and pharmaceutical excipients was studied using thermal analysis (DSC and TG/DTG) and vibrational spectroscopy (FTIR). Modifications in the peak shape, peak onset or peak maximum were verified using thermal analysis, especially DSC, in the physical mixtures. FTIR spectra showed good correlation between INH and most of excipients. Lactose and sodium metabisulfite were found to exhibit interactions with isoniazid.

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Application of thermal analysis to the study of antituberculosis drugs–excipient compatibility

Cited by 41 publications

References 14 publications

Inclusion Complexes of Copaiba (Copaifera multijuga Hayne) Oleoresin and Cyclodextrins: Physicochemical Characterization and Anti-Inflammatory Activity

Inclusion Complexes of Copaiba (Copaifera multijuga Hayne) Oleoresin and Cyclodextrins: Physicochemical Characterization and Anti-Inflammatory Activity

Compatibility studies of hydrocortisone with excipients using thermogravimetric analysis supported by multivariate statistical analysis

Compatibility Study Between Isoniazid and Pharmaceutical Excipients Used in Solid Dosage Forms

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