Application of xenogeneic anti‐canine distemper virus antibodies in treatment of canine distemper puppies

Liu, Pin-Chen; Chen, C. A.; Chen, C. M.; Yen, Chon-Ho; Lee, M. H.; Chuang, Chin-Kai; Tu, Ching-Fu; Su, Bi-Ling

doi:10.1111/jsap.12557

Cited by 11 publications

(14 citation statements)

References 24 publications

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“…The antibody-mediated passive immunotherapy for CD began in the 1930s [ 41 ]. The clinical practice showed that antiserum or antibody could significantly reduce clinical symptoms and prolong the survival period of the diseased dogs [ 12 , 42 ]. For a long time, the antiserum or antibody used in clinical treatment of canine distemper and canine parvovirus mainly came from dogs [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, CD has become a common infectious disease in pet clinic [ 11 ]. Due to its excellent therapeutic effect, the most effective anti-CDV drug remains to be CDV antiserum (or antibody) that conveys satisfactory prevention and treatment of CD [ 12 ]. Currently, the antiserum or antibody used to prevent/treat CD was mainly derived from dogs (homologous animals) [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Donkey-derived anti-CDV IgG, as a passive immunotherapy agent, can effectively increase survival rates of the experimental CDV-infected dogs

et al. 2021

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Background Humoral immunity plays an important role in the prevention of canine distemper. Anti-CD virus (CDV) antibody has strong antiviral activity and is widely used in the treatment of CD. However, with the increase of CD cases, the availability of therapeutic CD antibody fell short of the clinical needs. Results The high-titer antiserum with the high-titer neutralizing activity against CDV was obtained from the donkeys (Dezhou Donkey) immunized with the inactivated CDV vaccine. The donkey anti-CDV IgG was purified from the donkey serum, which was identified to significantly inhibit the CDV replication in the cultured Vero cells and effectively reduce the clinical symptoms and increase the survival rates (75%) of CDV-infected dogs (Shih-tzu Dog), similar to that treated with the dog-derived anti-CDV IgG. These results indicate that donkey-derived IgG is a potential substitute for dog-derived IgG to treat the CD in clinic. Conclusions Administration of donkey-derived anti-CDV IgG can ameliorate clinical symptoms and inhibit virus replication, thereby increasing the survival of CDV-infected dogs. This study opens up a new source of therapeutic antibody for CD treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Donkey-derived anti-CDV IgG, as a passive immunotherapy agent, can effectively increase survival rates of the experimental CDV-infected dogs

et al. 2021

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“…Liu et al (2016) used the porcine anti-canine distemper virus IgG and F(ab′) 2 antibody fragments as passive immunotherapy to treat infected puppies exhibiting respiratory signs without neurological signs of distemper and showed that 76% of pups (19 out of 25) survived. However, 8 of 25 (32%) pups showed neurological symptoms during treatment(Liu et al 2016).…”

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confidence: 99%

Evaluation of The Anti-Newcastle Disease Vaccine Serum (ANDVS) on Canine Distemper

Arbabi

Mohebalian

2021

Preprint

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Distemper is a contagious, highly lethal, and almost incurable viral disease in dogs and other terrestrial carnivores. This study aimed to treat distemper in dogs with a novel method. Two healthy 10 and 12- month male dogs of mixed breed and weighed 31 and 33 Kg were prepared. A 1000-dose vial of Newcastle disease vaccine (Lasota strain) was then diluted in 6 ml normal saline and 3 ml of it was injected into the cephalic vein of each dog. Eleven hours later, the dogs were anesthetized and 20% of their blood volume was collected. Blood sera were separated and used as anti- Newcastle disease vaccine serum (ANDVS) to treat dogs suspected to have canine distemper. Dogs whose distemper was finally diagnosed by RT-PCR were grouped in the following seven treatment groups: 1- ANDVS; 2- ANDVS+ Cotrimoxazole; 3- ANDVS+ Penicillin-Gentamicin; 4- ANDVS+ Cefazolin-Amikacin; 5- Cotrimoxazole; 6- Penicillin-Gentamycin; 7- Cefazolin-Amikacin. Then the mortality rate of dogs, correlation between distemper and sex, breed, and age, and effects of distemper on hematological factors and vital signs were evaluated. The recovery rate in the ANDVS+ Cotrimoxazole and the ANDVS+ Cefazolin-Amikacin groups were higher than the ANDVS group (P<0.05). There was also a significant difference between the mortality rate in distemper positive and negative dogs. It is concluded that although ANDVS alone has no effect on the treatment of distemper, along with some antibiotics such as cotrimoxazole or cefazolin+ amikacin significantly improved the recovery rate compared to antibiotics used alone.

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“…Canine distemper (CD) is one of the most contagious and fatal diseases affecting all families of carnivores, including dogs and wild raccoons [ 10 , 17 , 29 ]. CDV (family Paramyxoviridae , genus Morbillivirus ) infection is a multisystemic disease affecting the respiratory and gastrointestinal tracts, central nervous system, and various other organs and tissues, and can induce immunosuppression [ 3 , 29 ].…”

mentioning

confidence: 99%

“…Although effective vaccines are commercially available, CD is still an important infectious disease in dogs and wild carnivores [ 24 , 25 , 32 ]. In many cases, progression of the disease may differ depending on factors such as the rearing environment, virus strain, age, and immune status of the individual [ 3 , 17 ].…”

mentioning

confidence: 99%

Serosurvey of rabies virus, canine distemper virus, parvovirus, and influenza virus in military working dogs in Korea

Kim

Yang

Seo

et al. 2018

The Journal of Veterinary Medical Science

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Rabies virus (RABV), canine distemper virus (CDV), canine parvovirus type-2 (CPV-2), and canine influenza A virus (CIV) are important contagious pathogens in canine populations. To assess post-vaccination immunity against RABV, CDV and CPV-2, and serological evidence of exposure to influenza A virus in military working dogs (MWDs) in Korea, we tested blood samples of 78 MWDs by fluorescent antibody virus neutralization (FAVN) for RABV, and by commercially available enzyme-linked immunosorbent assay (ELISA) for CDV, CPV-2, and CIV. Korean MWDs had high antibody-positive rates against RABV (97.4%, ≥0.5 IU/ml), CDV (94.8%), and CPV (100%). All dogs tested seronegative (0/78; 0%) for influenza A virus. Two 1-year-old dogs stationed in known rabies outbreak areas (Gangwon and Gyeonggi) exhibited VNA titers below the protective level (0.06 and 0.29 IU/ml, respectively). The breed and sex of MWDs were not significantly associated with antibody titers for RABV, CDV, or CPV; however, age was significantly associated with CPV antibody titers, while region of residence was associated with CDV antibody titer. Taken together, the data presented here provide important insights necessary for post-vaccination management and control of infectious diseases in MWDs.

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Application of xenogeneic anti‐canine distemper virus antibodies in treatment of canine distemper puppies

Abstract: Porcine anti-canine distemper virus antibodies improved survival in puppies affected with canine distemper with minimal adverse effects. Therefore, this therapy could be considered for treatment of endangered animal species infected with canine distemper virus.

Cited by 11 publications

References 24 publications

Donkey-derived anti-CDV IgG, as a passive immunotherapy agent, can effectively increase survival rates of the experimental CDV-infected dogs

Donkey-derived anti-CDV IgG, as a passive immunotherapy agent, can effectively increase survival rates of the experimental CDV-infected dogs

Evaluation of The Anti-Newcastle Disease Vaccine Serum (ANDVS) on Canine Distemper

Serosurvey of rabies virus, canine distemper virus, parvovirus, and influenza virus in military working dogs in Korea

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