Applications of Chitosan Nanoparticles in Drug Delivery

Abstract

We have reviewed the binding affinities of several antitumor drugs doxorubicin (Dox), N-(trifluoroacetyl) doxorubicin (FDox), tamoxifen (Tam), 4-hydroxytamoxifen (4-Hydroxytam), and endoxifen (Endox) with chitosan nanoparticles of different sizes (chitosan-15, chitosan-100, and chitosan-200 KD) in order to evaluate the efficacy of chitosan nanocarriers in drug delivery systems. Spectroscopic and molecular modeling studies showed the binding sites and the stability of drug-polymer complexes. Drug-chitosan complexation occurred via hydrophobic and hydrophilic contacts as well as H-bonding network. Chitosan-100 KD was the more effective drug carrier than the chitosan-15 and chitosan-200 KD.

Investigation of curcumin release from chitosan/cellulose micro crystals (CMC) antimicrobial films

“…450 g per g of film. These films were designated as Ch/CMC (0) 450 , Ch/CMC (10) 450 , Ch/CMC (20) 450 , and Ch/CMC (30) 450 , where the number in subscript is the amount of curcumin in g present in 1 g of the film.…”

“…The de-acetylation is carried out under strong alkaline conditions and degree of de-acetylation varies with the experimental conditions [8]. Chitosan is a biocompatible and biodegradable polymer and has a number of biomedical applications which include wound dressings [9], drug delivery [10], porous scaffolds for cells re-generation [11,12], etc. Because of low cost, abundant availability and excellent film forming capability [13], it is also used in food packaging [14].…”

Cancer drug delivery in the nano era: An overview and perspectives

“…Natural polymers that are extensively used in nanoparticle synthesis include chitosan, dextran, albumin, heparin, gelatin, and collagen ( 42 , 43 ). Chitosan-coated PLGA nanoparticles ( 44 , 45 ) and chitosan nanoparticles ( 46 – 49 ) can carry and deliver proteins in an active form and transport them to specific organs. Synthetic polymers, such as PEGylated PLA nanoparticles and PLA-PEG-PLA nanoparticles ( 50 – 54 ), poly-PLGA nanoparticles ( 55 ), monomethoxypolyethylene glycol-block-polycaprolactone nanoparticles ( 56 ), and N-(2-hydroxypropyl)-methacrylamide copolymers ( 57 ), assist in the transport of proteins within the drug capsules.…”

Drug Delivery Systems of Natural Products in Oncology

“…Natural polymers extensively used in nanoparticle synthesis include chitosan, dextran, albumin, heparin, gelatin and collagen [ 68 , 69 ]. Chitosan-coated PLGA (poly(lactic-co-glycolic acid) NPs [ 70 ] and chitosan NPs [ 71 , 72 , 73 ] can carry and deliver proteins in an active form to specific organs.…”