Applications of nanoparticles in cancer medicine and beyond: optical and multimodalin vivoimaging, tissue targeting and drug delivery

Abstract

The progressive breakthroughs in nanomedicine have supported the development of multifunctional and multimodal NPs. In particular, NPs are significantly impacting the diagnostic and therapeutic strategies since they allow the development of: NP-based OI probes containing more than one modality-specific contrast agent; surface functionalized NPs for specific 'molecular recognition'. Therefore, the design and characterization of innovative NP-based systems/devices have great applicative potential into the medical field.

The delivery of doxorubicin of multifunctional β‐cyclodextrin‐modified CdSe/ZnS quantum dots for bioactivity and nano‐probing

“…Nanoparticles play an important role in medicine . Quantum dots (QDs) nanoparticles have special photochemistry properties due to their special chemical and physical properties, which can be used in probing, bio‐imaging, sensing, and drug delivery, as well as diagnosis .…”

“…β-cyclodextrin, doxorubicin, drug deliver, nano-probing, quantum dots 1 | INTRODUCTION Nanoparticles play an important role in medicine. [1][2][3] Quantum dots (QDs) nanoparticles have special photochemistry properties due to their special chemical and physical properties, which can be used in probing, [4][5][6][7] bioimaging, [8][9][10] sensing, [11,12] and drug delivery, [13][14][15][16] as well as diagnosis. [17][18][19] Although QDs have generated numerous biological applications, the chief hinders are the organellespecific initiation of QDs, when QD nanoparticles are used in vivo.…”

Nanodiamonds and nanoparticles as tumor cell radiosensitizers—promising results but an obscure mechanism of action

“…While cancer still represents one of the most serious threats to human health, a boom of nanoparticle applications has been experienced in medicine in the last decade, in the fields of both diagnostics and therapy [reviewed in (1)(2)(3)(4)(5)]. Hence, it is not surprising that in order to fight malignant diseases a veritable 'ZOO' of nanoparticles is being investigated (6).…”

In vivo stepwise immunomodulation using chitosan nanoparticles as a platform nanotechnology for cancer immunotherapy

“…Since DCs have a high capacity for antigen uptake, various nanomaterials have been developed for their specific physicochemical properties and are currently studied for their potential as drug delivery systems for immunotherapy14 as tools for molecular imaging1516, and as antitumor therapeutics1718. Chitosan (CH) is a particularly attractive option for clinical and biological applications because of its low immunogenicity, low toxicity, biocompatibility, and biodegradability19202122.…”