To address the issue of malware detection through large sets of applications, researchers have recently started to investigate the capabilities of machine-learning techniques for proposing effective approaches. So far, several promising results were recorded in the literature, many approaches being assessed with what we call in the lab validation scenarios. This paper revisits the purpose of malware detection to discuss whether such in the lab validation scenarios provide reliable indications on the performance of malware detectors in real-world settings, aka in the wild.To this end, we have devised several Machine Learning classifiers that rely on a set of features built from applications' CFGs. We use a sizeable dataset of over 50 000 Android applications collected from sources where state-of-the art approaches have selected their data. We show that, in the lab, our approach outperforms existing machine learning-based approaches. However, this high performance does not translate in high performance in the wild. The performance gap we observed-F-measures dropping from over 0.9 in the lab to below 0.1 in the wild -raises one important question: How do state-of-the-art approaches perform in the wild ?