Appraisal of Antihyperlipidemic Activities of Lentinus lepideus in Hypercholesterolemic Rats

Singh

2014

Chin. J. Integr. Med.

188

Flavonoids are a widely distributed group of phytochemicals having benzo-pyrone nucleus, and more than 4,000 different flavonoids have been described and categorized into flavonols, flavones, flavanones, isoflavones, catechins and anthocyanidins. Flavonoids occurs naturally in fruits, vegetables, nuts, and beverages such as coffee, tea, and red wine, as well as in medical herbs. Flavonoids are responsible for the different colors of plant parts and are important constituents of the human diet. Flavanoids have different pharmacological activities, such as antioxidant, anti-allergic, antibacterial, anti-inflammatory, antimutagenic and anticancer activity. Naringenin belongs to the flavanones and is mainly found in fruits (grapefruit and oranges) and vegetables. Pharmacologically, it has anticancer, antimutagenic, anti-inflammatory, antioxidant, antiproliferative and antiatherogenic activities. Naringenin is used for the treatments of osteoporosis, cancer and cardiovascular diseases, and showed lipid-lowering and insulin-like properties. In the present review, detailed pharmacological and analytical aspects of naringenin have been presented, which revealed the impressive pharmacological profile and the possible usefulness in the treatment of different types of diseases in the future. The information provided in this communication will act as an important source for development of effective medicines for the treatment of various disorders.

Section: Extraction and Isolation Techniques Of Naringeninmentioning

confidence: 99%

A Review on Pharmacological and Analytical Aspects of Naringenin

Singh

2014

Chin. J. Integr. Med.

188

“…Redhead & Ginns, belonging to the family Polyporaceae, was previously named Lentinus lepideus. It grows in China, Thailand, Japan and Korea [4,58,162,163]. It is worth noting that while some authors qualify this mushroom as edible, others describe it as inedible.…”

Section: Neolentinus Lepideus (Fr) Redhead and Ginnsmentioning

confidence: 99%

“…Phytochemical investigations of N. lepideus established the presence in the fruiting bodies of two new secondary metabolites, 5-methoxyisobenzofuran-4,7(1H,3H)-dione 67 70were isolated from an EtOAc extract of a culture filtrate and showed tyrosinase inhibitory activity with IC 50 values of 173 and 263 µg/mL, respectively [167]. Extracts from the fruiting bodies of N. lepideus have been reported to possess antioxidant [168], antityrosinase [168], antihyperlipidemic [163], and immunomodulating activities [169,170]. [4,58,162,163].…”

Section: Neolentinus Lepideus (Fr) Redhead and Ginnsmentioning

confidence: 99%

“…Extracts from the fruiting bodies of N. lepideus have been reported to possess antioxidant [168], antityrosinase [168], antihyperlipidemic [163], and immunomodulating activities [169,170]. [4,58,162,163]. It is worth noting that while some authors qualify this mushroom as edible, others describe it as inedible.…”

Section: Neolentinus Lepideus (Fr) Redhead and Ginnsmentioning

confidence: 99%

See 1 more Smart Citation

Bioactive Phytochemical Constituents of Wild Edible Mushrooms from Southeast Asia

et al. 2020

Mushrooms have a long history of uses for their medicinal and nutritional properties. They have been consumed by people for thousands of years. Edible mushrooms are collected in the wild or cultivated worldwide. Recently, mushroom extracts and their secondary metabolites have acquired considerable attention due to their biological effects, which include antioxidant, antimicrobial, anti-cancer, anti-inflammatory, anti-obesity, and immunomodulatory activities. Thus, in addition to phytochemists, nutritionists and consumers are now deeply interested in the phytochemical constituents of mushrooms, which provide beneficial effects to humans in terms of health promotion and reduction of disease-related risks. In recent years, scientific reports on the nutritional, phytochemical and pharmacological properties of mushroom have been overwhelming. However, the bioactive compounds and biological properties of wild edible mushrooms growing in Southeast Asian countries have been rarely described. In this review, the bioactive compounds isolated from 25 selected wild edible mushrooms growing in Southeast Asia have been reviewed, together with their biological activities. Phytoconstituents with antioxidant and antimicrobial activities have been highlighted. Several evidences indicate that mushrooms are good sources for natural antioxidants and antimicrobial agents

Bioscience, Biotechnology, and Biochemistry

“…The water-soluble exopolysaccharides obtained from submerged culture of N. lepideus exhibited immunomodulatory activities [26]. The extracts of N. lepideus fruiting body have showed antihyperlipidemic activities in hypercholesterolemic rats [27] and strong antioxidant activity in inhibiting the oxidation of β-carotene and in scavenging 1,1-diphenyl-2-picrylhydrazyl radicals [28]. Moreover, the extracts inhibited xanthine oxidase and tyrosinase activities.…”

Section: Inhibition Of Tyrosinases By 1 Andmentioning

confidence: 99%

Novel tyrosinase inhibitors from liquid culture ofNeolentinus lepideus

Ishihara

Ide

Bito

et al. 2018

Tyrosinase is the key enzyme that controls melanin formation in the human skin. We performed a screening of 96 extracts of mushroom cultures and fruiting bodies for examining their inhibitory activity against mushroom tyrosinase. The ethyl acetate extracts of culture filtrate of Neolentinus lepideus exhibited the strongest inhibitory activity. The active compounds 1 and 2 were purified by repeated chromatographic separations from the extract. On the basis of spectroscopic analyses, 1 and 2 were identified to be 1,3-dihydroisobenzofuran-4,5,7-triol and 5-methoxy-1,3-dihydroisobenzofuran-4,7-diol, respectively. Lineweaver-Burk plot of the enzyme reaction in the presence of 1 indicated that 1 was a potent competitive inhibitor. The respective IC values of 1 and 2 were 173 and 263 μg/mL. Compound 1 at 15 μg/mL suppressed melanin accumulation stimulated by α-MSH in the murine melanoma B16 cells, as well as the induced accumulation of both tyrosinase transcript and protein without inhibiting cell proliferation.