New knowledge about maleefemale differences in pathophysiology, diagnosis, and treatment is shifting the practice of medicine from a one-size-fits all approach to a more individualized process that considers sex-specific interventions at the point of care. In this article, we review how clinical practice guideline committees can incorporate a structured framework to determine whether sex-specific assessments of the quality of the evidence or the particular recommendations should be made. The process can be operationalized by societies who author clinical practice guidelines by developing formal policies to approach biological sex in a systematic way, and by ensuring that writing committees include an individual who will champion the formal appraisal of the literature for associations between sex and the outcomes of interest. Ongoing challenges are discussed, and solutions are provided for how to disaggregate the evidence, how to assess bias, how to improve search strategies, and what to do when the data are
Sex Matters in Cardiovascular DiseaseCardiovascular medicine is arguably most advanced in its understanding of clinically significant biologic differences between the sexes, from prevention to treatment. 3,4 Risk factors for heart disease and stroke are known to vary between men and women. 5,6 Clinical presentations of acute coronary syndrome differ, men experience earlier onset disease, and