Aptamer-assisted superparamagnetic iron oxide nanoparticles as multifunctional drug delivery platform for chemo-photodynamic combination therapy

Sun, Xueqing; Liu, Bing; Chen, Xianli; Lin, Hui-Chao; Peng, Yi; Li, Yanyu; Zheng, Haoran; Xu, Yibin; Ou, Xulin; Yan, Siqi; Wu, Zonghai; Deng, Shujun; Zhang, Luyong; Zhao, Ping

doi:10.1007/s10856-019-6278-y

Cited by 32 publications

(32 citation statements)

References 38 publications

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“…SPIONs have already been explored for a vast variety of biomedical purposes, including magnetic resonance imaging (MRI) [ 3 , 4 ], tissue engineering [ 5 , 6 ] and cell separation [ 7 ]. Due to their unique magnetic properties, they gained a lot of interest in the field of controlled drug delivery [ 8 , 9 ], photodynamic therapy [ 10 , 11 ] and hyperthermia [ 12 , 13 ], thus SPIONs are regarded as one of the most promising candidates for the development of novel methods for cancer treatment. Numerous studies utilized SPIONs for magnetically mediated hyperthermia—a concept based on the fact that the viability of malignant cells is lower at temperatures above 41 °C in comparison to non-malignant cells [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles Modified with Silica Layers as Potential Agents for Lung Cancer Treatment

et al. 2020

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Superparamagnetic iron oxide nanoparticles (SPIONs) are promising drug delivery carriers and hyperthermia agents for the treatment of cancer. However, to ensure their safety in vivo, SPIONs must be modified in order to prevent unwanted iron release. Thus, SPIONs were coated with silica layers of different morphologies: non-porous (@SiO2), mesoporous (@mSiO2) or with a combination of non-porous and mesoporous layers (@SiO2@mSiO2) deposited via a sol–gel method. The presence of SiO2 drastically changed the surface properties of the nanoparticles. The zeta potential changed from 19.6 ± 0.8 mV for SPIONs to −26.1 ± 0.1 mV for SPION@mSiO2. The Brunauer–Emmett–Teller (BET) surface area increased from 7.54 ± 0.02 m2/g for SPIONs to 101.3 ± 2.8 m2/g for SPION@mSiO2. All types of coatings significantly decreased iron release (at least 10 fold as compared to unmodified SPIONs). SPIONs and SPION@mSiO2 were tested in vitro in contact with human lung epithelial cells (A549 and BEAS-2B). Both nanoparticle types were cytocompatible, although some delay in proliferation was observed for BEAS-2B cells as compared to A549 cells, which was correlated with increased cell velocity and nanoparticles uptake.

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Section: Introductionmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles Modified with Silica Layers as Potential Agents for Lung Cancer Treatment

et al. 2020

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“…The formation of G-quadruplex structure for AS1411 aptamer was thus confirmed. 33,34,40,41 The presence of porphyrin in the PpIX-Apt-UCNP nanospheres could be further confirmed by the results of solid state UV-Vis spectra (Figure 2(b)). It was found that UCNP has no substantial absorption while the PpIX-Apt-UCNP has the characteristic absorption peak (Soret band around 410 nm) of porphyrin.…”

Section: Synthesis and Characterization Of Ppix-apt-ucnpmentioning

confidence: 57%

“…Meanwhile, our previous research indicates that singlet oxygen ( 1 O 2 ) is the main species produced by porphyrin compounds under irradiation. [32][33][34]47 To further understand the mechanism of the photodynamic cell cytotoxicity of the PpIX-Apt-UCNP nanospheres, we evaluated the 1 O 2 generation by the absorption change of RNO following the Kraljic procedure. 39 PS PpIX in the light irradiation could react with O 2 to produce 1 O 2 and the intermediates of 1 O 2 and could cause RNO oxidation, resulting in the absorbance reduction of RNO at 440 nm.…”

Section: Cell Photocytotoxicity and Singlet Oxygen Generation Of Ppixmentioning

confidence: 99%

“…On the other hand, the quadruplex structures have been previously proved to be able to load porphyrin PS, such as N-methylmesoporphyrin IX (NMM) and 5, 10, 15, 20-tetrakis (1-methylpyridinium-4-yl) porphyrin (TMPyP). [32][33][34][35][36][37] Since the AS1411 aptamer is an excellent selector for the higher nucleolin-expressing cancer cells and a good candidate for carrying porphyrin ligands because of its quadruplex structure, it has been frequently employed as a tether for the drug nanocarrier.…”

Section: Introductionmentioning

confidence: 99%

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Aptamer-guided upconversion nanoplatform for targeted drug delivery and near-infrared light-triggered photodynamic therapy

Lin

Madanayake

et al. 2019

J Biomater Appl

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Current photodynamic therapy faces two major challenges, which are the limited tissue penetration of excitation light and poor tumor selectivity of the photosensitizer. To address these issues, in the present work, a photosensitizer protoporphyrin IX was delivered by aptamer-coated upconversion nanoparticles. The aptamer, namely, AS1411, could fold to G-quadruplex structures with the bi-functions of loading protoporphyrin IX and targeting the cancerous cells. The protoporphyrin IX aptamer-coated upconversion nanoparticle nanospheres exhibited good biocompatibility, high nuclease resistance, and targeted cellular internalization. The receptor blocking experiment indicated that the cellular uptake of protoporphyrin IX aptamer-coated upconversion nanoparticle mainly attributed to the binding of AS1411 to the nucleolin overexpressed on the cancerous cell membrane. Moreover, high-efficient photodynamic therapy of the asprepared protoporphyrin IX aptamer-coated upconversion nanoparticle nanospheres was achieved to cancerous cells under the irradiation of near-infrared light, which was induced by the upconversion property of the upconversion nanoparticle. These results indicate that the fabricated protoporphyrin IX aptamer-coated upconversion nanoparticle nanoplatform has higher efficiency, lower toxicity, and less side effects compared to the free photosensitizer protoporphyrin IX, and thus is a new promising photodynamic therapy agent especially for the deep-seated tumors.

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“…Magnetic nano-particles can be organic or inorganic and present some interesting features since they can be guided through a magnetic field, heated, and thus triggering drug release or to producing hyperthermia/tissue ablation and also superparamagnetic nano-particles can be visualized by magnetic resonance imaging [ 106 ]. The most used bulk materials for magnetic applications are iron oxide (Fe 3 O 4 ) and manganese ferrite (MnFe 2 O 4 ) [ 107 ].…”

Section: G-quadruplexes Conjugated With Nano-particlesmentioning

confidence: 99%

G-Quadruplex-Based Drug Delivery Systems for Cancer Therapy

2021

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G-quadruplexes (G4s) are a class of nucleic acids (DNA and RNA) with single-stranded G-rich sequences. Owing to the selectivity of some G4s, they are emerging as targeting agents to overtake side effects of several potential anticancer drugs, and delivery systems of small molecules to malignant cells, through their high affinity or complementarity to specific targets. Moreover, different systems are being used to improve their potential, such as gold nano-particles or liposomes. Thus, the present review provides relevant data about the different studies with G4s as drug delivery systems and the challenges that must be overcome in the future research.

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Aptamer-assisted superparamagnetic iron oxide nanoparticles as multifunctional drug delivery platform for chemo-photodynamic combination therapy

Cited by 32 publications

References 38 publications

Superparamagnetic Iron Oxide Nanoparticles Modified with Silica Layers as Potential Agents for Lung Cancer Treatment

Superparamagnetic Iron Oxide Nanoparticles Modified with Silica Layers as Potential Agents for Lung Cancer Treatment

Aptamer-guided upconversion nanoplatform for targeted drug delivery and near-infrared light-triggered photodynamic therapy

G-Quadruplex-Based Drug Delivery Systems for Cancer Therapy

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