Aptamer duo-based portable electrochemical biosensors for early diagnosis of periodontal disease

Joe, Cheulmin; Lee, Bang Hyun; Kim, Sang Hoon; Ko, Youngkyung; Gu, Man Bock

doi:10.1016/j.bios.2021.113884

Cited by 41 publications

(14 citation statements)

References 40 publications

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“…The LOD was calculated by three times the standard deviation of the blank according to the reference. [ 29 , 30 ] Compared to previous reports, our developed portable electrochemical sensing platform exhibited excellent analytical performance. A comparison was shown in Table 1 .…”

Section: Resultsmentioning

confidence: 93%

“…A portable biosensor can be particularly significant as home health monitoring and personal healthcare become more and more common during the COVID-19 pandemic [ 23 , 24 ]. In recent years, portable sensors have been widely used in the field of disease diagnosis [ 25 , 26 , 27 ], e.g., a commercial, portable blood glucometer for detecting blood glucose, portable smartphone-based devices for monitoring cardiovascular diseases [ 28 ], portable biosensors for coronavirus disease [ 29 ], and portable electrochemical biosensors for the early diagnosis of periodontal disease [ 30 ]. However, very few portable electrochemical sensing platforms are reported in the field of AD diagnosis [ 16 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

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Portable Vertical Graphene@Au-Based Electrochemical Aptasensing Platform for Point-of-Care Testing of Tau Protein in the Blood

Liu

et al. 2022

Biosensors

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Alzheimer’s disease (AD) is a long-term neurodegenerative disease that poses a serious threat to human life and health. It is very important to develop a portable quantitative device for AD diagnosis and personal healthcare. Herein, we develop a portable electrochemical sensing platform for the point-of-care detection of AD biomarkers in the blood. Such a portable platform integrates nanoAu-modified vertical graphene (VG@Au) into a working electrode, which can significantly improve sensitivity and reduce detection limit due to the large specific surface, excellent electrical conductivity, high stability, and good biocompatibility. The tau protein, as an important factor in the course of AD, is selected as a key AD biomarker. The results show that the linear range of this sensing platform is 0.1 pg/mL to 1 ng/mL, with a detection limit of 0.034 pg/mL (S/N = 3), indicating that this portable sensing platform meets the demand for the detection of the tau protein in the blood. This work offers great potential for AD diagnosis and personal healthcare.

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Section: Resultsmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Portable Vertical Graphene@Au-Based Electrochemical Aptasensing Platform for Point-of-Care Testing of Tau Protein in the Blood

Liu

et al. 2022

Biosensors

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“…[431] ✓ Likewise, when real sample analysis is performed in the laboratory, the sample is diluted many times. [432,433] However, at the clinical level, the diagnostics need to be performed with un-diluted real samples which leads to the change in results owing to the high concentration of the electrolyte and interfering species.…”

Section: Current Challenges Future Prospects and Conclusion For Mxene...mentioning

confidence: 99%

2D MXene‐Based Biosensing: A Review

Amara

Hussain

Ahmad

et al. 2022

Small

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MXene emerged as decent 2D material and has been exploited for numerous applications in the last decade. The remunerations of the ideal metallic conductivity, optical absorbance, mechanical stability, higher heterogeneous electron transfer rate, and good redox capability have made MXene a potential candidate for biosensing applications. The hydrophilic nature, biocompatibility, antifouling, and anti‐toxicity properties have opened avenues for MXene to perform in vitro and in vivo analysis. In this review, the concept, operating principle, detailed mechanism, and characteristic properties are comprehensively assessed and compiled along with breakthroughs in MXene fabrication and conjugation strategies for the development of unique electrochemical and optical biosensors. Further, the current challenges are summarized and suggested future aspects. This review article is believed to shed some light on the development of MXene for biosensing and will open new opportunities for the future advanced translational application of MXene bioassays.

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“…Besides, integrating sample preparation into the device allows the possibility of direct analysis within a sample matrix and offers opportunities for new strategies of long-term analysis in vivo, among many other exciting applications. Electrochemical nanohybrid biosensors are particularly suitable for miniaturization and integration in microfluidic devices, thus reducing the consumption of reagents and samples [179,180]. Applications include detecting whole cells, cell components, proteins, and small molecules to address diagnostics and food and environmental control tasks online and in real-time, but still require more sophisticated platforms with additional elements, such as sample preparation.…”

Section: Limitations Opportunities and Concluding Remarksmentioning

confidence: 99%

Hybrid Nanobioengineered Nanomaterial-Based Electrochemical Biosensors

Soto

Orozco

2022

Molecules

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Nanoengineering biosensors have become more precise and sophisticated, raising the demand for highly sensitive architectures to monitor target analytes at extremely low concentrations often required, for example, for biomedical applications. We review recent advances in functional nanomaterials, mainly based on novel organic-inorganic hybrids with enhanced electro-physicochemical properties toward fulfilling this need. In this context, this review classifies some recently engineered organic-inorganic metallic-, silicon-, carbonaceous-, and polymeric-nanomaterials and describes their structural properties and features when incorporated into biosensing systems. It further shows the latest advances in ultrasensitive electrochemical biosensors engineered from such innovative nanomaterials highlighting their advantages concerning the concomitant constituents acting alone, fulfilling the gap from other reviews in the literature. Finally, it mentioned the limitations and opportunities of hybrid nanomaterials from the point of view of current nanotechnology and future considerations for advancing their use in enhanced electrochemical platforms.

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Aptamer duo-based portable electrochemical biosensors for early diagnosis of periodontal disease

Cited by 41 publications

References 40 publications

Portable Vertical Graphene@Au-Based Electrochemical Aptasensing Platform for Point-of-Care Testing of Tau Protein in the Blood

Portable Vertical Graphene@Au-Based Electrochemical Aptasensing Platform for Point-of-Care Testing of Tau Protein in the Blood

2D MXene‐Based Biosensing: A Review

Hybrid Nanobioengineered Nanomaterial-Based Electrochemical Biosensors

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