2012
DOI: 10.1159/000343305
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Aquaporin-2 Levelsin vitroandin vivoare Regulated by VACM-1, a Cul 5 Gene

Abstract: Background: In the renal collecting duct, vasopressin regulates water permeability by a process that involves stimulation of adenylyl cyclase activity, cAMP production and subsequent translocation of water channel aquaporin-2 (AQP2) into the apical plasma membrane. We have previously shown that in cos 1 cells in vitro, both adenylyl cyclase activity and cAMP production can be regulated by VACM-1, a cul 5 gene that forms complexes involved in protein ubiquitination and subsequent degradation. Methods: To extend… Show more

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Cited by 7 publications
(1 citation statement)
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“…Cul5 neddylation was also increased by 24 h of water deprivation, and AQP1 levels were inversely correlated with the ratio of Cul5 to neddylated Cul5 [ 40 ]. Furthermore, overexpression of Cul5 downregulated AQP2, and Cul5 was decreased in renal collecting ducts in response to water deprivation [ 41 ]. Cul5 mRNA levels were increased in the brainstem and cerebellum, and decreased in the hypothalamus of rats by hemorrhagic shock [ 42 ].…”
Section: Identification and Regulation Of Cullinmentioning
confidence: 99%
“…Cul5 neddylation was also increased by 24 h of water deprivation, and AQP1 levels were inversely correlated with the ratio of Cul5 to neddylated Cul5 [ 40 ]. Furthermore, overexpression of Cul5 downregulated AQP2, and Cul5 was decreased in renal collecting ducts in response to water deprivation [ 41 ]. Cul5 mRNA levels were increased in the brainstem and cerebellum, and decreased in the hypothalamus of rats by hemorrhagic shock [ 42 ].…”
Section: Identification and Regulation Of Cullinmentioning
confidence: 99%