Aqueous extract of Baccharis trimera improves redox status and decreases the severity of alcoholic hepatotoxicity

Rabêlo, Ana Carolina Silveira; Araújo, Glaucy Rodrigues de; Lúcio, Karine de Pádua; Araújo, Carolina Morais; Miranda, Pedro Henrique de Amorim; Silva, Breno de M.; Carneiro, Ana Cláudia Alvarenga; Ribeiro, Érica Milena de Castro; Lima, Wanderson Geraldo de; Souza, Gustavo Henrique Bianco de; Brandão, Geraldo Célio; Costa, Daniela Caldeira

doi:10.1016/j.bjp.2017.09.003

Cited by 13 publications

(8 citation statements)

References 55 publications

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“…Hypoglycemic effects of B. trimera have also been reported (Coelho et al 2004, Lívero et al 2016b, Cosenza et al 2019, in addition to vasorelaxant activity in rat aortic rings (Gómez et al 2016). The most scientifically corroborated effect of B. trimera is hepatoprotective activity against liver injury that is caused by multiple risk factors (Lívero et al 2016a, Rabelo et al 2017, Barbosa et al 2020). An increase in hepatocyte proliferation was previously found in rats after partial hepatectomy (Lima et al 2017).…”

Section: An Acad Brasmentioning

confidence: 99%

Hepato- and cardioprotective effects of Baccharis trimera (Less.) DC. against multiple risk factors for chronic noncommunicable diseases

Mendes¹,

Silva²,

Silva

et al. 2021

An. Acad. Bras. Ciênc.

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Cardiovascular diseases are associated with high morbidity and mortality worldwide and have several risk factors, including dyslipidemia, smoking, and hypertension. Studies have evaluated isolated risk factors in experimental models of cardiovascular disease, but few preclinical studies have assessed associations between multiple risk factors. In the present study, hypertensive Wistar rats (Goldblatt 2K1C model) received a 0.5% cholesterol diet and were exposed to tobacco smoke for 8 weeks.During the last 4 weeks, the animals were treated with vehicle, an ethanol-soluble fraction of B. trimera (30, 100, and 300 mg/kg), or simvastatin + enalapril. A group of normotensive, non-dyslipidemic, and non-smoking rats was treated with vehicle. The levels of aspartate aminotransferase, alanine aminotransferase, urea, creatinine, and hepatic and fecal lipids, blood pressure, and mesenteric arterial bed reactivity were evaluated. Cardiac, hepatic, and renal histopathology and tecidual redox state were also investigated. Untreated animals exhibited signifi cant changes in blood pressure, lipid profi le, and biomarkers of heart, liver, and kidney damage. Treatment with B. trimera reversed these changes, with effects that were similar to simvastatin + enalapril. These fi ndings suggest that B. trimera may be promising for the treatment of cardiovascular and hepatic disorders, especially disorders that are associated with multiple risk factors.

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Section: An Acad Brasmentioning

confidence: 99%

Hepato- and cardioprotective effects of Baccharis trimera (Less.) DC. against multiple risk factors for chronic noncommunicable diseases

Mendes¹,

Silva²,

Silva

et al. 2021

An. Acad. Bras. Ciênc.

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“…The most striking feature of polyphenols is undoubtedly their ability to capture reactive oxygen species (ROS), which include both radical and non-radical oxygen species, as well as oxidative free radicals derived from biomolecules, such as low-density lipoproteins (LDL), proteins and oligonucleic acids [32]. This antioxidant ability is frequently associated to the property underlying the prevention and/or reduction of oxidative stressrelated diseases [33][34][35], such as diabetes [30]; cardiovascular diseases [36], neurodegeneration [5], inflammation [33] and carcinogenesis [37][38][39][40]. It is known that cancer is characterized by sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis [41].…”

Section: Discussionmentioning

confidence: 99%

Luehea candicans Increase In Vitro Cell Cancer Metabolism Even with High Polyphenols Content

Camara¹,

Rabêlo²,

Borghesi³

et al. 2019

Med Aromat Plants

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Brazil is the country with the greatest biodiversity; however, most of the plants are used empirically, without scientific evidence. Luehea candicans, popularly called as-açoita-cavalo, is a specie characteristic of the Brazilian Cerrado Biome, used for fight hemorrhages, dysenteries, diarrhea, rheumatism and tumors. On the other hands, there are practically no studies about chemical composition and assess of their biological effects. Thus, the aim of this investigation was characterize and evaluate the antitumor potential of crude hydroethanolic extract from the bare stem parts of this plant, as well as its ethyl acetate and methanolic fractions. For the characterization, the crude extract was submitted to qualitative (phytochemical screening and analysis by direct flow injection by mass spectrometry-FIA-ESI-IT-MS) and quantitative tests (determination of phenolic compounds and determination of total flavonoids and anthocyanins).In order to study the antitumor potential, MTT technique was used to evaluate the cellular metabolism of canine breast cancer tumor cells (TCM) and osteosarcoma (OST). The results demonstrated the presence of polyphenols, mainly flavonoids and tannins. In addition, were observed an increase in metabolism when TCM and OST cells were incubated with all extracts of L candicans. Based on this, L candicans in these tumor types should be careful use, and that in vivo studies should be performed to prove the true effects of this plant.

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“…Baccharis dracunculifolia has been described as the primary botanical source of Brazilian green propolis, responsible for many bioactive constituents of this propolis [ 8 ]. In addition, this Brazilian native plant has been widely used for medicinal purposes, including to treat gastrointestinal diseases, inflammation, and liver disorders [ 9 , 10 ]. Regarding its anti-inflammatory potential, a few studies have described that B. dracunculifolia mitigates the inflammatory process in macrophages [ 11 ] and in rodents [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Baccharis dracunculifolia DC Hydroalcoholic Extract Improves Intestinal and Hippocampal Inflammation and Decreases Behavioral Changes of Colitis Mice

França

Ribeiro

Mariano

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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The hydroalcoholic extract of B. dracunculifolia (HEBD) and its major compound p-coumaric acid were evaluated against the severity of intestinal inflammation and behavioral changes like depressive and anxious behavior in colitis mice. Colitis was induced in Swiss mice by oral dextran sulfate sodium (DSS) administration for five days. The mice received vehicle (10 ml/kg), HEBD (3, 30, or 300 mg/kg), or p-coumaric acid (15 mg/kg) orally, once a day for twelve days. Behavioral tests were performed on the 11th and 12th days after the beginning of the treatments. Moreover, the colon, cortex, and hippocampus were collected to analyze oxidative and inflammatory parameters. The treatment with HEBD (300 mg/Kg), but not p-coumaric acid, showed decreased disease activity index (DAI) values compared to the vehicle group and partially preserved the villi architecture and mucin levels. Furthermore, the HEBD increased the antioxidant defenses in the colon and hippocampus and reduced the myeloperoxidase activity and IL-6 levels in the colon from colitis mice. Colitis mice treated with HEBD did not show depressive-like behavior in the tail suspension test. HEBD reduced colon inflammation, while it maintains antioxidant defenses and mucin levels in this tissue. It may reduce neuropsychiatric comorbidities associated with colitis through its antioxidant effects.

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Aqueous extract of Baccharis trimera improves redox status and decreases the severity of alcoholic hepatotoxicity

Cited by 13 publications

References 55 publications

Hepato- and cardioprotective effects of Baccharis trimera (Less.) DC. against multiple risk factors for chronic noncommunicable diseases

Hepato- and cardioprotective effects of Baccharis trimera (Less.) DC. against multiple risk factors for chronic noncommunicable diseases

Luehea candicans Increase In Vitro Cell Cancer Metabolism Even with High Polyphenols Content

Baccharis dracunculifolia DC Hydroalcoholic Extract Improves Intestinal and Hippocampal Inflammation and Decreases Behavioral Changes of Colitis Mice

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