Aqueous Extract of Brazilian Berry (Myrciaria jaboticaba) Peel Improves Inflammatory Parameters and Modulates Lactobacillus and Bifidobacterium in Rats with Induced-Colitis

Abstract

Natural compounds could be a complementary alternative to inflammatory bowel disease (IBD) management. This study determined the effects of an aqueous extract of Myrciaria jaboticaba peel (EJP) (50 g L−1) on 2,4,6-trinitrobenzenesulfonic acid-induced colitis. Wistar rats were randomized into five groups: HC—healthy control, CC—colitis control, DC—drug control, SJ—short-term treatment with EJP, and LJ—long-term treatment with EJP. The EJP treatments reduced body weight loss, stool consistency score, and spleen enlargement. Gut microbiota was modulated through increased Lactobacillus and Bifidobacterium counts after EJP treatment. Short-chain fatty acids were also higher in the EJP treatment groups. The antioxidant enzyme activities were greater than CC or DC controls. Myeloperoxidase activity (LJ), inducible nitric oxide synthase (LJ/SJ), and intercellular adhesion molecule (SJ) levels were lower than in the CC group. EJP decreased histological scoring, mucosal thickness, and preserved the crypts and histological structure. Therefore, EJP showed beneficial effects and could be potentially used as an adjuvant in IBD treatment.

Targeting Gut Microbiota and Host Metabolism with Dendrobium officinale Dietary Fiber to Prevent Obesity and Improve Glucose Homeostasis in Diet‐Induced Obese Mice

“…[48] In addition, aqueous extract of berry peel enriched Bifidobacterium and alleviate inflammatory response in rats. [49] Inflamma-tory cytokines can interfere with insulin signal transduction and cause insulin resistance in obesity. [50] Here we speculate that the anti-inflammation effect of DODF may be conducive to activate insulin-mediated PI3K/Akt/GSK3𝛽 pathway in HFD-induced obese mice, leading to an enhanced glucose clearance capacity.…”

Plant Extracts Rich in Polyphenols as Potent Modulators in the Growth of Probiotic and Pathogenic Intestinal Microorganisms

“…Based on published data on the effect of polyphenols on the growth of probiotic bacteria, one possible explanation for the stimulation of growth is that probiotics could metabolize polyphenols during growth (63,64). Some microorganisms can hydrolyze O-glycosylated polyphenols to aglycone and glucose, which they can use for their growth, as a sole source of energy and carbon (65)(66)(67). Also, L. plantarum can degrade p-coumaric, caffeic, ferulic, coumaric, gallic and protocatechuic acid to obtain energy (13,68,69).…”

Chemoprevention with a tea from hawthorn (Crataegus oxyacantha) leaves and flowers attenuates colitis in rats by reducing inflammation and oxidative stress

“…CAT acts as a first-line defense against the formation of free radicals, while GR is responsible for the regeneration of GHS, the body master’s antioxidant ( Fagan and Palfey, 2010 , Ighodaro and Akinloye, 2018 , Pérez et al, 2017 ). According to recent studies, GR can be increased in rats with improved TNBS-induced colitis, and that received rich sources of flavonoids (jaboticaba peel and grape peel residues) ( da Silva-Maia et al, 2019 , Maurer et al, 2019 ). This scenario suggests the importance of GR restoration to ameliorate intestinal conditions.…”

“…Acute colitis was induced on the 14th day using TNBS (10 mg) dissolved in 250 μL of 50% ethanol (v/v) ( da Silva-Maia et al, 2019 ) and administrated via rectal in rats previously sedated intraperitoneally with ketamine (75 mg/kg of body weight) and xylazine (10 mg/kg of body weight). Groups without colitis induction ( C, H ) received saline solution (0.9%) instead of TNBS.…”

“…Mesalamine, a drug commonly used to treat IBDs ( Lacucci et al, 2010 ), was diluted in distilled water and given via gavage at a dosage of 100 mg/kg/day ( da Silva-Maia et al, 2019 ). Mesalamine was administrated for seven days, from the day of the induction until the end of the experiment.…”